Morphological characteristics of cardiac myxoma causing embolism: a series of 40 years of experience at a single institute

Amemiya, Kisaki; Yonemoto, Yumiko; Ishibashi‐Ueda, Hatsue; Matsumoto, Manabu; Ohta‐Ogo, Keiko; Ikeda, Yoshihiko; Kobayashi, Junjiro; Fukushima, Satsuki; Fujita, Tomoyuki; Hatakeyama, Kinta

doi:10.1007/s00428-022-03461-x

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Histologically, cardiac myxomas can be classified into three categories all with equal prevalence: round-smooth types (34%), irregular types (30%) and villous types (36%). Of the three types, the villous type is the most likely to embolise (OR 8.7 (95% CI 2.4 to 42.1; p<0.001) 8. Notably, the villous type, seen in our case, can share a similar appearance with papillary fibroelastomas, another primary cardiac tumour known to embolise 9.…”

Section: Discussionmentioning

confidence: 52%

Vasculitic rash and cerebral emboli in an adolescent with left atrial myxoma

An,

Marshall,

Cusimano

2024

BMJ Case Rep

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A previously healthy woman in late adolescence presented to the emergency department with stroke-like symptoms following a two-month history of bilateral foot pain and oedema, accompanied by a macular rash and progressive lower extremity weakness. On further investigation, she was found to have multiple cerebral emboli and a left atrial myxoma fixed to the interatrial septum. The patient subsequently underwent urgent surgical excision of the myxoma. On follow-up, her cutaneous and neurological symptoms were significantly improved. This case suggests that, in the presence of a vasculitic rash without evident or obvious cause, cardiac myxoma should be included in the differential diagnosis.

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Section: Discussionmentioning

confidence: 52%

Vasculitic rash and cerebral emboli in an adolescent with left atrial myxoma

An,

Marshall,

Cusimano

2024

BMJ Case Rep

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Cardiac myxoma: biological features, morphology, differential diagnosis

Vasilyev,

Krakhmal,

Vtorushin

et al. 2024

Rus. J. Arch. Pathol.

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Left atrial myxoma metastasizing to the brain: a case report and review of literature

Basu,

Grindrod,

Dar

et al. 2024

Radiat Oncol J

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Cardiac myxomas, the most common primary cardiac tumors, are believed to originate from multipotent mesenchymal cells. Approximately 75% of myxomas occur within the left atrium, increasing the risk of systemic thromboembolic events. While typically benign, atrial myxomas can rarely metastasize to the brain, with fewer than 60 cases reported. We present a case of a 56-year-old woman with a history of left atrial myxoma who developed headaches, right arm weakness, and blurry vision three months post-cardiac surgery. Imaging showed multiple hemorrhagic brain lesions, and she was treated with whole brain radiotherapy (20 Gy/5 fractions). Four years later, she remains stable with no new lesions and has fully regained function. Currently, there is no standard management for cardiac myxoma metastases. This case highlights the potential role of radiotherapy in managing brain metastases from left atrial myxomas, suggesting a possible treatment strategy based on this case and a review of the literature.

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Morphological characteristics of cardiac myxoma causing embolism: a series of 40 years of experience at a single institute

Cited by 3 publications

References 24 publications

Vasculitic rash and cerebral emboli in an adolescent with left atrial myxoma

Vasculitic rash and cerebral emboli in an adolescent with left atrial myxoma

Cardiac myxoma: biological features, morphology, differential diagnosis

Left atrial myxoma metastasizing to the brain: a case report and review of literature

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