Morphological characteristics of radicular cysts using computed tomography

Sukegawa, Shintaro; Matsuzaki, Hidenori; Katase, Naoki; Kawai, Hiroki; Kanno, Takahiro; Asaumi, Jun Ichi; Furuki, Yoshihiko

doi:10.1007/s10266-019-00443-5

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…The lesions of radicular cysts always form the radiolucent areas in the jawbone; some cases exhibited perilesional sclerotic radiolucency (Zhao et al, 2014), and most patients with this type lack acute clinical symptoms, such as pain and swelling; however, almost all the patients without perilesional sclerosis exhibit acute symptoms (Sukegawa et al, 2019). In the unsclerotized cysts, the inconspicuous lesion border resembles that of some odontogenic keratocysts (OKC), which is characterized by local aggressiveness of the jawbone (Wang, Jiang, et al, 2015; Wang & Li, 2013).…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of fibroblasts from radicular cyst influenced osteoclastogenesis and bone destruction

Yang

Wang

2020

Oral Diseases

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Aim To analyze the heterogeneity of fibroblasts isolated from the fibrous capsules of radicular cysts and explore the effects of fibroblast subsets on bone destruction. Methodology Radicular cysts were divided into groups according to varying perilesional sclerosis identified by radiograph. Colony‐forming units (CFUs) were isolated from the fibrous capsules of cysts, by which Trap + MNCs were induced, and the expression of osteoclastogenesis‐related genes was compared among groups by real‐time PCR. The variances in gene profiles of CFUs were identified by principal component analysis, and then, CFUs were divided into subsets using cluster analysis. The induction of Trap + MNCs and related gene expression was compared among subsets, and osteoclastogenic induction was blocked by IST‐9 or bevacizumab. The fibroblast subsets in cysts were investigated by retrospective immunostaining with IST‐9, VEGF‐A, and CD34. A fibroblast subset that underwent gene editing by CRISPR/Cas was injected into the site of bone defects in animal models, and the in vivo effects on osteoclastogenesis were investigated. Results The fibroblast CFUs isolated from radicular cysts with perilesional unsclerotized cysts induced more Trap + MNCs than those with perilesional sclerotic cysts (p < .05). Most fibroblast CFUs from unsclerotized cysts belonged to Cluster 2, which induced more Trap + MNCs (p < .05) and highly expressed genes facilitating osteoclastogenesis; these results were different from those of Cluster 1 (p < .05), in which most CFUs were isolated from perilesional sclerotic cysts or controls (p < .05). The high expression of EDA + FN and VEGF‐A was investigated in both the fibroblasts of Cluster 2 and the fibrous capsules of unsclerotized cysts (p < .05), and the number of Trap + MNCs induced by Cluster 2 was decreased by treatment with IST‐9 and bevacizumab (p < .05). Consistently, EDA exon exclusion significantly decreased the osteoclastogenic induction of fibroblasts from Cluster 2 in vivo (p < .05). Conclusion The fibrous capsules of radicular cysts contain heterogeneous fibroblasts that can form subsets exhibiting different effects on osteoclastogenesis. The subset, which depending on the autocrine effects of EDA + FN on VEGF‐A, mainly contributes to the osteoclastogenesis and bone destruction of radicular cysts. The regulation of the proportion of subsets is a possible strategy for artificially interfering with osteoclastogenesis.

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Section: Discussionmentioning

confidence: 99%

Heterogeneity of fibroblasts from radicular cyst influenced osteoclastogenesis and bone destruction

Yang

Wang

2020

Oral Diseases

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“…Kazemipoor et al (28) analysed periapical lesions on anterior teeth in an Iranian population, and Sukegawa et al (29) analysed periapical cysts in all positions of the mouth. They both suggested that periapical lesions do not maintain circularity as they spread and that they do not spread uniformly throughout the jaws, but rather, take the path of least resistance in bone.…”

Section: Discussionmentioning

confidence: 99%

A Novel Volume-based Cone-beam Computed Tomographic Periapical Index

Boubaris

Chan

Zhao

et al. 2021

Journal of Endodontics

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“…Este hallazgo coincide con el de Ducommun et al (3) con 9,70 ± 3,12 mm y 9,66 ± 3,44 mm, respectivamente; esto también podría deberse a la expansión ósea producida por el tamaño de la lesión periapical. La expansión ósea de lesiones quísticas radiculares en el maxilar ya ha sido observada previamente por Sukegawa et al (26); asimismo, se conoce que la mayor frecuencia de quistes perirradiculares se da en el maxilar anterior (25). En el estudio de Kazemipoor et al (12) se halló que la extensión de las lesiones periapicales de dientes anteriores maxilares era mayor en sentido ápicocoronal, seguido del sentido vestíbulo-palatino y mesiodistal.…”

Section: Dondeunclassified

Distancia de la raíz a las tablas óseas y piso nasal de dientes anteriores maxilares con indicación de microcirugía apical

Granados-Laura,

Chávez-Alayo,

Quezada-Márquez

et al. 2023

Rev Estomatol Herediana

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Objetivo: Evaluar la distancia de la raíz a las tablas óseas y piso nasal de dientes anteriores maxilares con indicación de microcirugía apical. Material y métodos: La muestra fue de 44 imágenes tomográficas computarizadas de haz cónico previas al procedimiento de microcirugía apical; además, se seleccionaron 31 imágenes para la comparación con los dientes contralaterales sin indicación de microcirugía apical. Se midió la distancia de la raíz a las tablas óseas y al piso nasal. Resultados: La distancia de la superficie radicular a las tablas óseas vestibular y palatina a 3 mm del ápice fue de 0,98 ± 0,67 mm y 4,26 ± 2,97 mm para el incisivo central; 0,77 ± 0,50 mm y 2,12 ± 1,22 mm para el incisivo lateral; y 0,52 ± 0,63 mm y 5,31 ± 1,38 mm para el canino, respectivamente. La distancia más corta del ápice al piso nasal fue de 9,56 ± 2,88 mm para el incisivo central; 10,33 ± 2,97 mm para el incisivo lateral; y 5,73 ± 2,57 mm para el canino. Solo se encontró una distancia mayor, estadísticamente significativa, del ápice al piso nasal del incisivo lateral con indicación de microcirugía apical en comparación con el incisivo lateral sin indicación de microcirugía apical. Conclusiones: La distancia de la raíz a la tabla ósea vestibular es menor que la distancia de la misma a la tabla ósea palatina. El ápice más próximo al piso nasal fue del canino. Los dientes anteriores maxilares con y sin indicación de microcirugía apical mostraron distancias similares de la raíz a las tablas óseas y piso nasal.

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Morphological characteristics of radicular cysts using computed tomography

Cited by 12 publications

References 23 publications

Heterogeneity of fibroblasts from radicular cyst influenced osteoclastogenesis and bone destruction

Heterogeneity of fibroblasts from radicular cyst influenced osteoclastogenesis and bone destruction

A Novel Volume-based Cone-beam Computed Tomographic Periapical Index

Distancia de la raíz a las tablas óseas y piso nasal de dientes anteriores maxilares con indicación de microcirugía apical

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