Morphological derivation overflow as a result of disruption of the left frontal aslant white matter tract

Sierpowska, Joanna; Gabarrós, Andreu; Fernández-Coello, Alejandro; Camins, Àngels; Castañer, Sara; Juncadella, Montserrat; Diego‐Balaguer, Ruth de; Rodrı́guez-Fornells, Antoni

doi:10.1016/j.bandl.2015.01.005

Cited by 63 publications

(55 citation statements)

References 89 publications

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“…Although the DTI studies could be supported by the data from the functional MRIs, a handful of clinical studies with intraoperative stimulation and monitoring confirm that reactions to FAT compromise might be different [3,8,10,13,[15][16][17]19].…”

Section: Discussionmentioning

confidence: 94%

“…A recent study of patients suffering from primary progressive aphasia showed that pathological changes within the FAT affect verbal fluency with no influence on the overall language impairment, grammar deficits, repetition and single word comprehension [5]. The physiological roles of specific FAT subdivisions have not been fully revealed yet [16]. Lesions of the FAT bundle projecting to the pre-SMA resulted in loss of linguistic functions while the connections to the SMA were related to articulation and word production [1].…”

Section: Discussionmentioning

confidence: 99%

“…Although little is known about the functional properties of the FAT, there is a growing interest in that novel tract [3,9,12,15,16,19,20]. The functional roles of FAT can be scrutinised to motor functions and language processing.…”

Section: Discussionmentioning

confidence: 99%

“…In dominant hemisphere FAT is associated with the initiation of speech and the fluency [9,12]. Speech arrest was observed in frontal lobe tumours infiltrating FAT as well as during its intraoperative electrical stimulation in awake surgeries [11,16]. FAT disconnection is attributed to stuttering, progressive aphasia or the development of Fox-Chavany-Marie syndrome [5,13].…”

Section: Introductionmentioning

confidence: 99%

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Frontal aslant tract projections to the inferior frontal gyrus

et al. 2017

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Background: Frontal aslant tract (FAT) is a white matter bundle connecting the pre-supplementary motor area (pre-SMA) and the supplementary motor area (SMA) with the inferior frontal gyrus (IFG). The purpose of the present study was to evaluate the anatomical variability of FAT. Materials and methods: Total number of fibres and the lateralisation index (LI) were calculated. We attempted to find factors contributing to the diversity of FAT regarding IFG terminations to the pars opercularis (IFG-Op) and to the pars triangularis (IFG-Tr). Magnetic resonance imaging of adult patients with diffusion tensor imaging (DTI) with total number of 98 hemispheres composed a cohort. V-shaped operculum was the most common (60.5%). Results: Total number of FAT fibres had widespread and unimodal distribution (6 to 1765; median: 160). Left lateralisation was noted in 64.3% of cases and was positively correlated with total number of FAT fibres and the bundle projecting to IFG-Op (p < 0.01). LI correlated with total number of FAT fibres (r = 0.43, p < 0.01). FAT projected predominantly to IFG-Op (88.9%; 88 of 99). Only in 3 (3.1%) cases more fibres terminated in IFG-Tr than in IFG-Op. Total number of FAT fibres and number of fibres terminating at IFG-Op did not correlate with the ratio of fibre numbers: FAT/IFG-Op, FAT/IFG . The greater total number of fibres to IFG-Tr was, the higher were the ratios of p = 0.04 (Folia Morphol 2017; 76, 4: 574-581)

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frontal aslant tract projections to the inferior frontal gyrus

et al. 2017

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“…It is known that FAT plays a role in normal language development, as previously shown in young healthy individuals [13]. There is also some evidence that FAT is involved in language impairments due to primary progressive aphasia (PPA) [14], brain tumors [15,16,17], and stroke [18]. FAT is considered as a part of a "motor stream" mainly involved in speech production [19] and complementing the dorsal and ventral language streams [20].…”

Section: Introductionmentioning

confidence: 99%

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

Serra

Gabrielli

Tuzzi

et al. 2017

JAD

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The Frontal Aslant Tract (FAT) has been described as a bundle connecting the Broca's area to the Supplementary Motor Area (SMA) and the pre-SMA in both hemispheres.The functional properties of this tract, and its role in degenerative dementia, such as Alzheimer's disease (AD) still need to be fully clarified. The aim of this study was to explore the microstructural integrity of the FAT in patients with AD and its potential relationship with cognitive functioning. Twenty-three patients with AD and 25 healthy subjects (HS) were enrolled. All subjects underwent cognitive and MRI examination.MRI including diffusion sequences was used for probabilistic tractography analysis. We

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A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

Chiang,

Mudar,

Dugas

et al. 2024

Brain and Behavior

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Word finding difficulty is a frequent complaint in older age and disease states, but treatment options are lacking for such verbal retrieval deficits. Better understanding of the neurophysiological and neuroanatomical basis of verbal retrieval function may inform effective interventions. In this article, we review the current evidence of a neural retrieval circuit central to verbal production, including words and semantic memory, that involves the pre‐supplementary motor area (pre‐SMA), striatum (particularly caudate nucleus), and thalamus. We aim to offer a modified neural circuit framework expanded upon a memory retrieval model proposed in 2013 by Hart et al., as evidence from electrophysiological, functional brain imaging, and noninvasive electrical brain stimulation studies have provided additional pieces of information that converge on a shared neural circuit for retrieval of memory and words. We propose that both the left inferior frontal gyrus and fronto‐polar regions should be included in the expanded circuit. All these regions have their respective functional roles during verbal retrieval, such as selection and inhibition during search, initiation and termination of search, maintenance of co‐activation across cortical regions, as well as final activation of the retrieved information. We will also highlight the structural connectivity from and to the pre‐SMA (e.g., frontal aslant tract and fronto‐striatal tract) that facilitates communication between the regions within this circuit. Finally, we will discuss how this circuit and its correlated activity may be affected by disease states and how this circuit may serve as a novel target engagement for neuromodulatory treatment of verbal retrieval deficits.

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Morphological derivation overflow as a result of disruption of the left frontal aslant white matter tract

Cited by 63 publications

References 89 publications

Frontal aslant tract projections to the inferior frontal gyrus

Frontal aslant tract projections to the inferior frontal gyrus

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

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