2023
DOI: 10.1002/jdn.10256
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Morphological evidence of the protective effects of a synthetic chalcone against the striatal myelin damage induced by glutaric acid

Abstract: Ultrastructural features of striatal white matter and cells in an in vivo model of glutaric acidemia type I created by intracerebral injection of glutaric acid (GA) were analyzed by transmission electron microscopy and immunohistochemistry. To test if the white matter damage observed in this model could be prevented, we administered the synthetic chemopreventive molecule CH38 ((E)‐3‐(4‐methylthiophenyl)‐1‐phenyl‐2‐propen‐1‐one) to newborn rats, previous to an intracerebroventricular injection of GA. The study … Show more

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