Morphological features of the minor salivary glands

Hand, Arthur R.; Pathmanathan, Dharmini; Field, Ruth B.

doi:10.1016/s0003-9969(99)90002-x

Cited by 114 publications

(64 citation statements)

References 53 publications

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“…The salivary gland consists of the major glands, including the parotid, submandibular and sublingual and numerous smaller glands that are termed minor (Califano and Eisele, 1999;Hand et al, 1999). In humans, the majority of salivary gland tumors are generated in the parotid gland and most are benign.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

Brodie

et al. 2001

Oncogene

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Transgenic mice expressing speci®c oncogenes usually develop tumors in a stochastic fashion suggesting that tumor progression is a multi-step process. To gain further understanding of the interactions between oncogenes and tumor suppressor genes during tumorigenesis, we have crossed a transgenic strain (TG.NK) carrying an activated c-neu oncogene driven by the MMTV enhancer/promoter with p53-de®cient mice. cneu transgenic mice have stochastic breast tumor formation and normal appearing salivary glands. However, c-neu mice heterozygous for a p53 deletion develop parotid gland tumors and loose their wild type p53 allele. c-neu mice with a homozygous p53 deletion have increased rates of parotid tumor onset suggesting that inactivation of p53 is required and sucient for parotid gland transformation in the presence of activated c-neu. In contrast to the dramatic eect of p53 in parotid gland transformation, p53 loss has little eect on the rate or stochastic appearance of mammary tumors. In addition, p53 loss was accompanied by the down regulation of p21 in parotid gland tumors but not breast tumors. The parotid gland tumors were aneuploid and demonstrated increased levels of Cyclin D1 expression. These observations suggest that in c-neu transgenic mice, p53 alterations have dierential tissue eects and may be in¯uenced by the tissue speci®c expression of genes in¯uencing p53 activity.

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Section: Discussionmentioning

confidence: 99%

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

Brodie

et al. 2001

Oncogene

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“…Some SG were found in duct cells of von Ebner’s glands of rat [6], rabbit [40], mouse, hamster, monkey [34], and human [10]. In this study, we observed that the von Ebner’s duct cells contained small SG that were labeled with anti-amylase, similarly to parotid intercalated duct cells.…”

Section: Discussionmentioning

confidence: 55%

Immunohistochemical and Immunocytochemical Localization of Amylase in Rat Parotid Glands and von Ebner's Glands by Ion Etching-Immunoscanning Electron Microscopy

Yahiro

Inai

Tsutsui

et al. 2011

Acta Histochem. Cytochem

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The distribution of amylase in rat parotid glands and von Ebner’s glands was examined using ion etching-immunoscanning electron microscopy, which enables both light and electron microscopic observations of identical semi-thin resin sections immunolabeled with anti-α-amylase and immunogold in association with silver enhancement. At the light microscopic level, most acinar secretory granules (SG) and striated duct secretions of parotid glands were strongly stained dark brown. In von Ebner’s glands, acinar SG and duct secretions were weakly to strongly stained light to dark brown. At the electron microscopic level, labeling was observed as bright gold-silver particles. The labeling intensity of acinar SG of parotid glands was higher than that of von Ebner’s glands. In parotid glands, weak labeling of SG in transitional cells between acini and intercalated ducts, very weak labeling of SG in intercalated ducts, and strong labeling of striated duct secretions were observed. In von Ebner’s glands, the secretions and some SG of interlobular ducts were strongly labeled compared to those of intralobular ducts and SG of acini. Less amylase was synthesized in von Ebner’s acini compared to parotid acini, whereas von Ebner’s ducts may secrete significantly more amylase to modify saliva than parotid ducts.

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“…In the surrounding connective tissue, no specific IGFBP expression was observed. The minor salivary glands lack fibrous capsules, and the surrounding connective tissue simply blends into that of the adjacent submucosa or muscle (Hand et al 1999). The above IGFBPs may play a role in the development of ducts and acini in von Ebner's gland.…”

Section: Discussionmentioning

confidence: 99%

Expression of IGFBPs in the developing mouse submandibular and von Ebner’s glands

Suzuki

2005

Anat Embryol

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The expression of insulin-like growth factor binding proteins (IGFBPs) in the developing mouse submandibular and von Ebner's glands was determined by in situ hybridization and by an immunohistochemical method. In the submandibular glands, IGFBP-2 and IGFBP-4 mRNAs were expressed in the terminal end-buds (TEB) at E13-E17, concomitant with epithelial branching. IGFBP-3 mRNA was expressed in the mesenchyme surrounding the TEB; and IGFBP-5 mRNA, in the ducts. At E17, IGFBP-5 mRNA expression was observed not only in the ducts but also in the TEB. Similarly, IGFBP-4 mRNA expression was observed not only in the TEB but also in the mesenchyme. After birth, IGFBP-4 expression was observed only in the connective tissue and disappeared by P14. That of IGFBP-7 appeared at P1 and was observed in the connective tissue until P21. The IGFBP-5 mRNA expression pattern after birth was the same as that seen at E17, but at P21 IGFBP-5 was immunohistochemically expressed only in the duct. The mRNA level of IGFBP-2 expression at postnatal days was weak, but its protein was detected in the ducts and acini at P14-P21. In von Ebner's glands, which appeared at the base of the circumvallate papillae at E17, only IGFBP-2 and IGFBP-4 mRNAs were expressed in the ducts and acini. Postnatally, IGFBP-4 was substituted by IGFBP-5 in the same region. Immunohistochemically, IGFBP-5 and IGFBP-2 were expressed in the ducts and acini at P14-P21. Throughout the study, IGFBP-6 was not detected by in situ hybridization, the immunoreactivity for it was observed in the nerve fibers of submandibular and von Ebner's glands. These data support a role for these molecules as local mediators of salivary growth and differentiation.

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Morphological features of the minor salivary glands

Cited by 114 publications

References 53 publications

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

Immunohistochemical and Immunocytochemical Localization of Amylase in Rat Parotid Glands and von Ebner's Glands by Ion Etching-Immunoscanning Electron Microscopy

Expression of IGFBPs in the developing mouse submandibular and von Ebner’s glands

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