Morphological, immunohistochemical, and genetic analyses of epithelioid gastrointestinal stromal tumors

Shi, Jingli; Sun, Kunkun; Kong, Fangzhou; Shen, Danhua

doi:10.1016/j.anndiagpath.2023.152208

Annals of Diagnostic Pathology

2023

DOI: 10.1016/j.anndiagpath.2023.152208

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Morphological, immunohistochemical, and genetic analyses of epithelioid gastrointestinal stromal tumors

Jingli Shi,

Kunkun Sun,

Fangzhou Kong

et al.

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2024

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Gastrointestinal stromal tumor mimicking perineurioma: A case report

Pan,

Gao,

Yang

et al. 2024

Cytojournal

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Although gastrointestinal stromal tumor (GIST) can present with various histological characteristics, GIST mimicking perineurioma has not been previously reported. We present the case of a 47-year-old woman diagnosed with GIST after laparoscopic resection of a stomach tumor near the lesser curvature of the gastric body close to the cardia. Morphological features resembled a perineurioma. c.1504_1509 (p.A502_Y503) duplication was found in exon 9 of kinase insert domain receptor (c-KIT). This specific mutation is associated with constitutive activation of the c-KIT, which is crucial in the pathogenesis of GIST. Such unique histological characteristics broaden our understanding of the morphological diversity within GISTs and underscore the importance of considering an extended differential diagnosis when encountering atypical gastrointestinal tumors. This rare presentation may challenge conventional diagnostic criteria and could influence therapeutic strategies, emphasizing the need for comprehensive histological and molecular assessments in patient management.

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Gastrointestinal stromal tumor mimicking perineurioma: A case report

Pan,

Gao,

Yang

et al. 2024

Cytojournal

View full text Add to dashboard Cite

show abstract

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Morphological, immunohistochemical, and genetic analyses of epithelioid gastrointestinal stromal tumors

Cited by 1 publication

References 25 publications

Gastrointestinal stromal tumor mimicking perineurioma: A case report

Gastrointestinal stromal tumor mimicking perineurioma: A case report

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