Morphological, immunohistochemical and quantitative studies of murine brain mast cells after mating

Yang, Mei-Fang; Chien, Chung‐Liang; Lu, Kuo‐Shyan

doi:10.1016/s0006-8993(99)01935-6

Cited by 26 publications

(25 citation statements)

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“…Similar increases in LH and T are induced by mating in male rats (Kamel and Frankel, 1978; Graham and Dejardins, 1980). One hypothesis, therefore, is that the increases in brain mast cells observed here were triggered, at least in part, by changes in LH and T.Yang, Chien, and Lu (1999) demonstrated that the number of brain mast cells increased in male mice housed with females for up to 19 days, during which time pregnancy was confirmed. This increase in brain mast cells was observed in comparison with non-mated male mice.…”

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confidence: 59%

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Stimuli from Conspecifics Influence Brain Mast Cell Population in Male Rats

Asarian

Yousefzadeh

Silverman

et al. 2002

Hormones and Behavior

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It is well established that mast cells occur within the brain of many species, and that the brain mast cell population is not static, but changes with the behavioral and physiological state of the animal.In this study, we tested whether exposure to conspecifics alters the number of brain mast cells in male rats, and then investigated the nature of stimuli influencing the changes observed in the number and localization of brain mast cells. Five days of cohabitation with an ovariectomized, estrogen-progesterone (OVX + EP)-treated female resulted in the largest number of thalamic mast cells, while pairing with such a female physically separated by a wire mesh or with a novel male produced a smaller, but significant increase over other pairings (OVX females for 5 days, OVX and OVX + EP females for 1 day, familiar or isolated males for 5 days). In all groups, mast cells were localized within specific dorsal thalamic nuclei, including the paraventricular nucleus, anterior nuclear group, or mediodorsal, ventroposterior, or medial geniculate nuclei. The results suggest that the behavioral and/or endocrine factors associated with cohabitation with conspecifics are sufficient to alter the number of brain mast cell-specific nuclei in the thalami of male rats and thus can provide targeted delivery of neuromodulators to specific regions of the brain that process information concerning the normal physiological state of the animal. Keywordsfemale; thalamus; mating; aggressive; endocrine; immune; stress Although mast cells are well known in their role as effectors of IgE-mediated allergic reactions, their physiological function(s) remains poorly understood (Wedemeyer, Tsai, and Galli, 2000; Forsberg, Pejler, Ringwall, Lunderius, Tomasini-Johansson, Kusche-Gullberg, Eriksson, Ledin, Hellman, and Kjellen, 1999;Echtenacher, Mannel, and Hultner, 1996;Malaviya, Ikeda, Ross, and Abraham, 1996). Recent evidence indicates that bacterial recognition followed by endocytosis, processing and presentation of bacterial antigen, immune cell recruitment, and elimination of parasites number among these functions (McLachlan and Abraham, 2001;Vincent-Schneider, Thery, Mazzeo, Tenza, Raposo, and Bonnerot, 2001;Abraham and Malaviya, 2000; Fox, Jewel, and Whitacre, 1994). In addition, mast cells synthesize, store, and secrete a wide variety of bioactive molecules, including neuropeptides, neurotransmitters, prostaglandins, chemotactic factors, and (Galli, 2000;Metcalfe, Baram, and Mekori, 1997;Silver, Silverman, Vitkovic, and Lederhendler, 1996;Johnson and Krenger, 1992).Mast cells are normally present in the mammalian brain, both in the leptomeninges and within the parenchyma along the blood vessels of several dorsal thalamic nuclei (Dropp, 1972(Dropp, , 1976Theoharides, 1990;Goldschmidt, Hough, Glick, and Padawer, 1984). The number of brain mast cells is modulated by physiological and behavioral state. Our demonstration that mature mast cells can migrate from the vasculature into the adult rat brain parenchyma provides a possible mechani...

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confidence: 59%

“…Yang, Chien, and Lu (1999) demonstrated that the number of brain mast cells increased in male mice housed with females for up to 19 days, during which time pregnancy was confirmed. This increase in brain mast cells was observed in comparison with non-mated male mice.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 94%

Stimuli from Conspecifics Influence Brain Mast Cell Population in Male Rats

Asarian

Yousefzadeh

Silverman

et al. 2002

Hormones and Behavior

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“…Psychological stressors induced through social defeat and isolation stress increased the number of mast cells in the brain (26,63). Last, gonadal hormones from conspecifics during mating also increase mast cell number and activation in the brain (23,62,64).…”

Section: Mast Cells Are Active Both Constitutively and Following Stimmentioning

confidence: 99%

Brain mast cells link the immune system to anxiety-like behavior

Nautiyal

Ribeiro

Pfaff

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

163

119

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“…This phenomenon is not unfounded, however. Studies in adult doves have demonstrated the recruitment of circulating mast cells to specific brain nuclei within hours of certain stereotyped behaviors (Silver et al 1996;Yang et al 1999). It will be of great interest to understand more fully the potential for vascular cells, possibly both endothelial and hematopoietic, to influence neuronal activity and plasticity.…”

Section: Jankowsky Et Almentioning

confidence: 99%

Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques

Jankowsky¹,

Derrick²,

Patterson³

2000

Learn. Mem.

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Because exogenous application of a number of cytokines and growth factors can alter synaptic properties, we sought to determine if endogenous cytokine expression is affected by neuronal activity. In addition, we examined whether cytokine expression is altered by the techniques used to stimulate and record from hippocampal neurons. Using semi-quantitative RNase protection and RT-PCR assays, we studied the expression of 18 cytokine, growth factor, and receptor genes in the hippocampus following the induction of Schaffer collateral-CA1 long-term potentiation (LTP). We found that various cytokines are dramatically induced following preparation of slices for in vitro recording and as a result of injury following acute electrode placement in vivo. These increases can be overcome in vivo, however, using permanent electrodes implanted three weeks prior to testing. Using this chronic preparation, we found that interleukin-6 (IL-6) mRNA was upregulated nearly 20-fold by LTP induction in vivo, marking the first demonstration of endogenous regulation of this cytokine in response to LTP. In situ hybridization for IL-6 revealed that upregulation is tightly localized near the site of stimulation and is detected only in non-neuronal cells, identified as GFAP+ astrocytes and GFAP− cells within proximal blood vessels. Coupled with previous results showing that exogenously applied IL-6 can prevent the induction of LTP, this finding suggests a mechanism by which the local release of a cytokine could regulate LTP at nearby sites.

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Morphological, immunohistochemical and quantitative studies of murine brain mast cells after mating

Cited by 26 publications

References 41 publications

Stimuli from Conspecifics Influence Brain Mast Cell Population in Male Rats

Stimuli from Conspecifics Influence Brain Mast Cell Population in Male Rats

Brain mast cells link the immune system to anxiety-like behavior

Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques

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