Morphological, immunohistochemical, stereological and nuclear shape characteristics of proliferative leydig cell alterations in rats

Ettlin, Robert A.; Qureshi, S.; Perentes, Elias; Christen, H.; Gschwind, Rudolf; Buser, Marc; Oberholzer, M.

doi:10.1016/s0344-0338(11)80072-5

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Finasteride, a 5α- reductase inhibitor, has also been shown to produce Leydig cell tumors in mice (Prahalada et al 1994; Zwieten 1994). Various aspects of Leydig cell adenoma have also been described by Ettlin et al (1992); Qureshi et al (1991); and Rao and Reddy (1987).…”

Section: Testismentioning

confidence: 97%

“…Various aspects of Leydig cell adenoma have also been described by Ettlin et al (1992); Qureshi et al (1991); and Rao and Reddy (1987 In contrast to rats, rete testis adenoma in mice shows some degree of cellular pleomorphism. Proliferative lesions of the rete testes are rare spontaneous lesions in aging rats but are more common in mice (Yoshitomi and Morii 1984) and have been reported to occur in both species following prenatal treatment with diethylstilbestrol and cadmium chloride (Bullock, Newbold, and McLachlan 1988;Newbold et al 1985Newbold et al , 1986Rehm and Waalkes 1988).…”

Section: Adenoma Leydig Cell (Figures 55-58): Testismentioning

confidence: 99%

“…Morphometric investigations of proliferative Leydig cell changes in Wistar rats have confirmed that Leydig cell hyperplasias smaller than 3 normal seminiferous tubules, and benign Leydig cell tumors larger than 3 normal seminiferous tubules differ cytologically: nuclei of hyperplastic Leydig cells are significantly smaller, more oval, and have more indentations. The larger neoplastic nuclei generally contain twice the amount of DNA found in normal or hyperplastic Leydig cells (Ettlin et al 1992). The definition of criteria for differentiation between ''normal'' and Leydig cell hyperplasia may be useful.…”

Section: Non-neoplastic Proliferative Lesions: Testis Introductionmentioning

confidence: 99%

“…Various aspects of Leydig cell adenoma have also been described by Ettlin et al (1992); Qureshi et al (1991); and Rao and Reddy (1987). In contrast to rats, rete testis adenoma in mice shows some degree of cellular pleomorphism.…”

Section: Neoplastic Proliferative Lesions: Testis Introductionmentioning

confidence: 99%

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

207

198

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Testismentioning

confidence: 97%

Section: Adenoma Leydig Cell (Figures 55-58): Testismentioning

confidence: 99%

Section: Non-neoplastic Proliferative Lesions: Testis Introductionmentioning

confidence: 99%

Section: Neoplastic Proliferative Lesions: Testis Introductionmentioning

confidence: 99%

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

207

198

View full text Add to dashboard Cite

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A brief review of modern toxicologic pathology in regulatory and explanatory toxicity studies of chemicals

et al. 1991

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Macroscopic and histologic evaluation of animal studies for general toxicity and carcinogenicity are cornerstones of the risk assessment of new chemical entities. Standard toxicopathologic evaluation is mainly based on the study of paraffin sections stained with hematoxylin and eosin. There are, however, a number of new approaches and techniques which have improved the objectivity of evaluation and the accuracy of cell identification, and provided deeper insight into the molecular biological mechanisms of toxicity and carcinogenicity. Such approaches include the standardization of the nomenclature, the creation of data banks for morphological alterations, the use of computers to register pathological findings in toxicity studies and to statistically evaluate incidences, and the use of morphometry. Other modern techniques are immunohistochemistry, in situ hybridization, and the assessment of cell kinetics.

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RITA—Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats

Nolte

Rittinghausen

Kellner

et al. 2011

Experimental and Toxicologic Pathology

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Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors.In the 7453 male rats available for analysis, only one case of a Leydig cell carcinoma was identified. The incidence of Leydig cell adenomas differed markedly between strains. High incidences of close to 100% have been found in F344 rats, while the mean incidence was 4.2% in Sprague Dawley rats and 13.7% in Wistar rats. Incidences in Wistar rats were highly variable, primarily caused by different sources of animals. Mean incidences per breeder varied from 2.8% to 39.9%.Analyses for the dependency on further parameters have been performed in Wistar rats. In breeders G and I, the Leydig cell tumor incidence decreased over the observation period and with increasing mean terminal body weight. The incidence of Leydig cell tumors increased with mean age at necropsy and was higher in studies with dietary admixture compared to gavage studies. These parameters had no effect on Leydig cell tumor incidence in breeders A and B. Animals from almost all breeders had a considerably higher mean age at necropsy when bearing a Leydig cell adenoma than animals without a Leydig cell adenoma. Studies with longitudinal trimming of the testes had a higher incidence than studies with transverse trimming.The observed dependencies and breeder differences are discussed and explanations are given.Consequences for the use of historical control data are outlined. With the retrospective Page 3 of 43 A c c e p t e d M a n u s c r i p t Nolte et al: RITA -The application of historical control data for Leydig cell tumors in rats -3 -analyses presented here we were able to confirm the published features of Leydig cell adenomas and carcinomas. This indicates that the RITA database is a valuable tool for analyses of tumors for their biological features. Furthermore, it demonstrates that the RITA database is highly beneficial for the definition of reliable historical control data for carcinogenicity studies on a scientifically solid basis.

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Morphological, immunohistochemical, stereological and nuclear shape characteristics of proliferative leydig cell alterations in rats

Cited by 6 publications

References 12 publications

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

A brief review of modern toxicologic pathology in regulatory and explanatory toxicity studies of chemicals

RITA—Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats

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