Morphological pathology of vessels in granulomatosis with polyangiitis (Wegener’s disease)

Zerbino, D D; Zimba, Olena

doi:10.17116/patol20157759-13

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Granulomatosis with polyangiitis is a multiorgan autoimmune disease with multifaceted clinical manifestations which, due to its rarity and the absence of distinctive clinical features, poses serious diagnostic challenges [ 2 ]. Diagnostic criteria for GPA consist of clinical evidence of disease in at least two of three areas (upper airways, lung, and kidney) and biopsy results showing disease at least once [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Granulomatosis with polyangiitis (GPA) is a rare rheumatologic disorder under the category of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with an annual reported incidence of 11.3 patients per million [ 1 ]. Diagnosis of the disease is challenging due to its various clinical manifestations [ 2 ], primarily involving the upper and lower respiratory tract and characterized by necrotizing granulomatous vasculitis of small- and medium-sized vessels [ 3 ]. Delay in diagnosis or management of this condition may lead to significant morbidity or even mortality [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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New onset unusual Wegener’s granulomatosis associated with COVID-19: a case report

Mandegari

Binesh

Abdollahpour

2023

Egypt J Otolaryngol

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Background Granulomatosis with polyangiitis (GPA) or Wegener’s granulomatosis is an autoimmune disorder with a wide spectrum of manifestations that mostly primarily presents with respiratory symptoms such as cough, dyspnea, and hemoptysis and leads to a high mortality rate if left untreated. It is a relatively uncommon condition, characterized by necrotizing granulomatous vasculitis of small- and medium-sized vessels. Recent studies have shown that hyperactivation of immune cells in patients with the coronavirus disease 2019 (COVID-19) leads to elevated levels of various autoantibodies and inflammatory cytokines including interferon-gamma (IFN-γ) and tumor necrosis factor-α (TNF-α). There are the same factors that involve in the pathogenesis of autoimmune diseases such as GPA. Case presentation While there have been several reported cases of COVID-19 occurring in patients receiving immunosuppressant treatment for GPA, here we report a case of a 72-year-old woman with a history of coronavirus disease 2019 (COVID-19) who suddenly suffered unilateral vision and hearing loss and peripheral facial palsy on the same side. Chest computed tomography (CT) demonstrated a subpleural consolidation in the inferior lobe of the left lung. Based on the radiology report, chest CT evidence was due to a history of COVID-19 pneumonia. CT scans of the paranasal sinus showed pansinusitis and necrosis of the nasal septum. According to the available evidence, mucormycosis was clinically suspected, and the patient underwent endoscopic sinus surgery. Eventually, the histopathological analysis revealed a diagnosis of Wegener’s granulomatosis. Conclusions Since GPA and its complications can be prevented only through strong clinical suspicion and early diagnosis, our presentation of this case aims to increase awareness of autoimmune diseases in COVID-19 patients even after recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New onset unusual Wegener’s granulomatosis associated with COVID-19: a case report

Mandegari

Binesh

Abdollahpour

2023

Egypt J Otolaryngol

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“…Гистологическая картина биопсийного материала, взятого из пораженных тканей слизистой оболочки дыхательных путей, характеризуется наличием системного панваскулита с поражением артерий и вен среднего и мелкого калибра, и некротизирующихся полиморфноклеточных гранулем с умеренным или небольшим количеством гигантских клеток типа Лангханса, что документально подтверждает диагноз ГПА [7].…”

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Balloon dilatation as a method of treatment of subglottic laryngeal stenosis in the patients with granulomatosis with polyangiitis

2019

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The main etiological causes of the development of subglottic stenosis of the larynx are the post-intubation changes and systemic diseases resulting in cicatricial phenomena in the area of the subglottic part of the larynx, that cause respiratory failure. The objective of the study was to improve the efficacy of treatment of the patients with subglottic stenosis of larynx, including the patients with granulomatosis with polyangiitis, using the method of balloon dilatation of respiratory tract. Materials and methods: the authors examined and treated 28 patients with subglottic laryngeal stenosis, an etiological factor of stenosis in 8 patients was prolonged intubation, in 12 other patients it was granulomatosis with polyangiitis, in 8 patients the stenosis was idiopathic. All the patients underwent surgical treatment – balloon dilatation under endoscopic control. Results: the result of balloon dilatation was a persistent expansion of the larynx diameter in all patients without intraoperative complications, thus avoiding open surgical interventions on the larynx. As a result of outpatient follow-up, a complication in the form of restenosis occurred in one patient with granulomatosis with polyangiitis, which was directly related to the recurrence of the underlying disease.

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Prostate involvement in granulomatosis with polyangiitis

et al. 2019

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Morphological pathology of vessels in granulomatosis with polyangiitis (Wegener’s disease)

Cited by 6 publications

References 2 publications

New onset unusual Wegener’s granulomatosis associated with COVID-19: a case report

New onset unusual Wegener’s granulomatosis associated with COVID-19: a case report

Balloon dilatation as a method of treatment of subglottic laryngeal stenosis in the patients with granulomatosis with polyangiitis

Prostate involvement in granulomatosis with polyangiitis

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