Morphological profile and receptor status in breast carcinoma: An institutional study

Abstract

Breast carcinoma in our population presents at younger age than Western population. Our results showed very high proportion of triple-negative breast cancers. The tumor size and grade is related to expression of only ER. The findings suggest that women in our population more often have histologically aggressive breast carcinoma at young age, likely to be less susceptible to conventional hormonal and targeted antibody treatment. Detecting and treating this increasing important cause of mortality will be an enormous challenge.

Clinico-Morphological Profile and Receptor Status in Breast Cancer Patients in a South Indian Institution

“…Alike some other studies, the hormone receptor status in the present study significantly correlated with the histological grade of breast tumors (Sofi et al, 2012;Shet et al, 2009;Ambroise et al, 2011). Similar to a regional study, lymphovascular space invasion was seen in less than 20% of the patients (Rao et al, 2013). Presence of histologic tumor necrosis has been found to be higher in Indian studies (Rao et al, 2013).…”

“…Similar to a regional study, lymphovascular space invasion was seen in less than 20% of the patients (Rao et al, 2013). Presence of histologic tumor necrosis has been found to be higher in Indian studies (Rao et al, 2013).…”

“…50% patients in the study had lymph nodal involvement on presentation, which indicates the aggressive nature of the tumors found in Indian population. Though data from developed countries suggest that most of the breast cancer patients do not have any lymph node metastasis, Indian studies have documented higher percentages of lymph nodal involvement in breast cancer patients (Taucher et al, 2003;Sofi et al, 2012;Rao et al, 2013). Most of the patients presented in TNM Stage II as most of the patients had tumor size between 2 to 5 cm and 50% of the patients did not have any lymph nodal disease.…”

Predictive and Prognostic Factors in Breast Cancer and their Association with ER PR HER2/neu Expression

“…Thus, higher the tumor grade, more the unfavourable receptor expression and therefore, worse the prognosis. This is also in agreement with other studies which state that tumor histologic grade is an important determinant of hormone receptor status [11][12][13][14][15]. Tatjana Ivković-Kapicl et al in corroboration with our study, observed that highergrade tumors were more likely to demonstrate HER2/neu amplification than lower grade ductal carcinomas [16].…”

The Prognostic Value of Luminal Subtypes of Breast Cancer and their Impact on the Patient's Outcome

“…(Table 1) According to recurrence, 66 patients reported the occurrence of recurrence representing 19.7% of total number of study patients; with 29 cases of loco-regional recurrence and 37 cases with distant relapse; while 269 patients had no relapse till the time of study representing 80.3% of total study patients which is statistically significant (p=0.000). (Figure 3 (47)(48)(49) As regards to the size of the tumors in our study, T2 tumors (2-5 cm in size) were the commonest presenting tumors in all molecular subtypes where they represented 60.5% of total number of patients, T1 (less than 2 cm) represented 24.0% of patients and T3 (more than 5 cm) represented 15.5% of total number of patients. Rakha EA et al conducted a study on 2,219 cases.…”