Morphological remodeling in mouse vagina due to hormonal hypersecretion

Oh, Min-Gee; Kim, Sang‐Hwan

doi:10.12750/jarb.37.1.42

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…According to previous literature, pyocolpos may appear spontaneously without any history of gynaecologic cancer or trauma (Buxant et al, 2006). In the experimental and industrial animals, the morphological changes in the vagina under several stimuli have been reported (Ali et al, 2020;Oh and Kim, 2022). However, the pathosis due to the imperforate hymen of the intact female dogs has not been understood yet.…”

Section: Discussionmentioning

confidence: 99%

Hematocolpos, pyocolpos, and pyocolpometra in intact female dogs with imperforate hymen

Kim

2022

J Anim Reprod Biotechnol

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Accumulations of fluid or blood with or without purulent material in the vagina or uterus are termed hydro/ hemato/pyo-colpos/colpometra. These disorders can occur in animals as well as human patients with a persistent hymen or acquired stenosis of the vagina. The hymen is formed by fusion of the Müllerian ducts and urogenital sinus, and usually regresses during the fetal or neonatal period in domestic animals (Sadler, 1985). Congenital vaginal obstructive disorders have been rarely reported in dogs and treatment options with surgical correction or laser ablation have been published (

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Section: Discussionmentioning

confidence: 99%

Hematocolpos, pyocolpos, and pyocolpometra in intact female dogs with imperforate hymen

Kim

2022

J Anim Reprod Biotechnol

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“…After the reaction, routine hematoxylin and eosin (H&E) staining was performed for histological inspection with optical microscope (Oh and Kim, 2022).…”

Section: In-situ Zymographymentioning

confidence: 99%

“…Therefore, this study analyzed the morphological and physiological differences between the uteri of water deer and sika deer in estrus and controlled tissue reorganization by decomposing collagen or gelatin, the main components of the extracellular matrix (Oh and Kim, 2022). This study was conducted to provide basic data for research on reproductive physiology in wild animals by analyzing the effects of MMPs and apoptosis on uterine reorganization during estrus.…”

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confidence: 99%

Morphological differences according to uterine tissue remodeling during estrus between sika deer and water deer

Oh,

Park,

Kim

2023

J Anim Reprod Biotechnol

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Alliin Induces Reconstitution of Testes Damaged by Estrogen Overstimulation by Regulating Apoptosis

Kim,

Oh,

Kim

2024

CIMB

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We analyzed the effect of alliin on the recovery of mouse testicular function and structure following estradiol treatment as well as on apoptosis regulation. During the cultivation of testicular cells, high-concentration estradiol suppressed Casp-3; PCNA, mTOR, and PI3K signaling increased; and cell proliferation in the testes was abnormally increased. Therefore, estradiol treatment increased the proportion of abnormal cells. The estradiol and 2.5 μM of alliin treatment increased Casp-3 levels and suppressed Bcl-2, PCNA, mTOR, and PI3K expression. Additionally, treatment with estradiol caused tissue loss. Furthermore, Ca2+ deposition decreased, TNF-r protein expression increased, and the levels of other protein markers of cell survival and death decreased. Tissue recovery and restoration of the testes occurred after alliin treatment; the gene expression of cell survival and death markers, except for TNF-r, increased with increasing Ca2+ deposition. Cell proliferation and tissue reorganization may correlate with an increased signal of intrinsic apoptosis owing to increased Ca2+ deposition. Therefore, treatment with alliin may regulate the apoptosis of cells with normal or abnormal signal transduction and help to revert testicular dysfunction.

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Morphological remodeling in mouse vagina due to hormonal hypersecretion

Cited by 3 publications

References 16 publications

Hematocolpos, pyocolpos, and pyocolpometra in intact female dogs with imperforate hymen

Hematocolpos, pyocolpos, and pyocolpometra in intact female dogs with imperforate hymen

Morphological differences according to uterine tissue remodeling during estrus between sika deer and water deer

Alliin Induces Reconstitution of Testes Damaged by Estrogen Overstimulation by Regulating Apoptosis

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