Morphological studies of an ion-dependent perinuclear cataract model

Groth-Vasselli, Barbara; Robinson, Della; Lally, Joseph; Schleich, Thomas; Farnsworth, Patricia N.

doi:10.1016/0014-4835(88)90052-8

Cited by 6 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The perinuclear zone is susceptible to damage. When rabbit lenses were exposed to media containing low sodium, nuclear cataract developed and was accompanied by cellular damage that was confined to a narrow band of cells 50 µm wide in the perinuclear zone (Groth-Vasselli et al, 1988). Dietary deficiencies can also result in opacification in the lens perinuclear region in new born cats (Remillard, Pickett and Thatcher, 1993).…”

Section: F 4 Equatorial and Axial Dimensions Of The Apparent Impementioning

confidence: 99%

An Impediment to Glutathione Diffusion in Older Normal Human Lenses: a Possible Precondition for Nuclear Cataract

Sweeney

Truscott

1998

Experimental Eye Research

211

184

View full text Add to dashboard Cite

Section: F 4 Equatorial and Axial Dimensions Of The Apparent Impementioning

confidence: 99%

An Impediment to Glutathione Diffusion in Older Normal Human Lenses: a Possible Precondition for Nuclear Cataract

Sweeney

Truscott

1998

Experimental Eye Research

211

184

View full text Add to dashboard Cite

Ocular pharmacokinetics of calcium, chloride and sulphate ions after instillation in the rabbit

Hariton

Mandel²

1991

Biopharm & Drug Disp

View full text Add to dashboard Cite

The ionic environment of the eye is involved in major biochemical processes which are essential for preserving the integrity of cornea and lens. The purpose of the present study was to determine the intra-ocular penetration and the pharmacokinetic parameters of calcium, chloride and sulphate ions in the cornea, iris-ciliary body (ICB) and lens, after administration by instillation in the rabbit eye. In order to extrapolate our results to the processes occurring in man, we followed a precise instillation protocol using a low volume (5 microliters) of 45Calcium, 36Chloride and 35Sulphate, which is less than the lacrimal volume determined during the palpebral closing and performing manual blinking at a frequency of 2 min-1. The results indicate an immediate trans-corneal permeability and a rapid ocular distribution of these ions. We observe that, relative to dose, an important percentage of calcium (67.20 per cent) was entrapped in the cornea; this parameter was less important for chloride (10.19 per cent) and for sulphate ions (3.25 per cent). These values are in agreement with those predicted theoretically for trans-corneal penetration by such compounds. On the other hand, the total degrees of penetration by chloride and sulphate ions in ICB (1.40 per cent and 0.90 per cent, respectively) and lens (0.35 per cent and 0.41 per cent, respectively) are quite similar. Calcium retention is much higher in these tissues (25.39 per cent in ICB and 16.03 per cent in lens).(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Phosphorus and proton magnetic resonance spectroscopic studies on the relationship between transparency and glucose metabolism in the rabbit lens

Williams

Austin

Farnsworth

et al. 1988

Experimental Eye Research

View full text Add to dashboard Cite

Morphological studies of an ion-dependent perinuclear cataract model

Cited by 6 publications

References 7 publications

An Impediment to Glutathione Diffusion in Older Normal Human Lenses: a Possible Precondition for Nuclear Cataract

An Impediment to Glutathione Diffusion in Older Normal Human Lenses: a Possible Precondition for Nuclear Cataract

Ocular pharmacokinetics of calcium, chloride and sulphate ions after instillation in the rabbit

Phosphorus and proton magnetic resonance spectroscopic studies on the relationship between transparency and glucose metabolism in the rabbit lens

Contact Info

Product

Resources

About