Morphologie mammaire dans le syndrome de Turner. Étude clinique prospective multicentrique de 21 cas

Bartolin, C.; Magalon, G.; Jallut, Y.; Bouvattier, Claire; Casanova, Dominique; Degardin, N.

doi:10.1016/j.anplas.2011.11.004

Cited by 5 publications

(11 citation statements)

References 21 publications

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“…Around 50% of the participants in the present study were satisfied with their breasts, with no differences between the diagnostic subgroups. The levels of breast dissatisfaction are largely in line with the existing literature (Bannink et al, 2006;Bartolin et al, 2012;Ediati et al, 2015;van de Grift et al, 2018). The lowered breast satisfaction is likely the result of the female-atypical breast size and/or morphology (Bartolin et al, 2012;Wu and Li, 2019).…”

Section: Factors Associated With Breast Satisfactionsupporting

confidence: 81%

“…A higher BMI, body embarrassment and mental health problems were associated with more breast dissatisfaction (van de Grift et al, 2018). In women with TS, one study reported breast satisfaction in 58% (Bannink et al, 2006), similar to another study reporting relatively low satisfaction (Bartolin et al, 2012). Although no reference data is provided in the aforementioned studies, other authors found satisfaction in around 80% of women without DSD (van de Grift et al, 2016).…”

Section: Introductionmentioning

confidence: 75%

“…While research showed that in the general population 90% of females reach the maximum of Tanner breast stage 5 (B5; and most others stage B4) (Mul et al, 2001), a maximum of 50% of women with TS was likely to reach B5 (Pertzelan et al, 1982;Bannink et al, 2009;Labarta et al, 2012). In addition, a wider chest (Wu and Li, 2019) but no major differences in breast morphology (Bartolin et al, 2012) were observed, when compared with controls.…”

Section: Introductionmentioning

confidence: 98%

“…With regard to breast satisfaction, even fewer studies have been published (Migeon et al, 2002;Bannink et al, 2006;Bartolin et al, 2012;Kulshreshtha et al, 2012;Ediati et al, 2015;Kanhere et al, 2015;van de Grift et al, 2018). In both males and females with DSD, breast satisfaction has been observed to be lower than control values (Ediati et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In girls/women with DSD, breast development may be limited, when compared with women without DSD, due to lower estrogen production and/or effects. Over the years, a few studies on breast development have been published considering women with TS (Pertzelan et al, 1982;Bannink et al, 2009;Bartolin et al, 2012;Labarta et al, 2012;Ankarberg-Lindgren et al, 2014;Sas et al, 2014;Tanaka et al, 2015;Wu and Li, 2019), CAH (Ning et al, 2008;Völkl et al, 2011;Kulshreshtha et al, 2012) and 46,XY (Pertzelan et al, 1982;Nihoul-Fékété et al, 2006). Among women with TS, 36% had spontaneous breast development (Tanaka et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mental health of a large group of adults with disorders of sex development in six European countries

Vries¹,

Roehle²,

Marshall³

et al. 2020

ESPE

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Compared with normative data, women with DSD reached lower Tanner stages and reported less breast satisfaction. WHAT IS KNOWN ALREADY: Women with DSD may have chromosomal and hormonal variations that can impact typical breast development. While much emphasis is placed on genital development in this group, little is known about breast development, satisfaction and their association. STUDY DESIGN, SIZE, DURATION: Data collection was part of the cross-sectional European multicenter dsd-LIFE study. Fourteen recruiting sites included 1040 participants between February 2014 and September 2015. PARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 695 female-identifying participants were included (Turner n = 332, 46,XY DSD n = 141 and congenital adrenal hyperplasia n = 222), with a median age of 28 years. Clinical (i.e. history of hormone and surgical treatments, Tanner breast examination) and patient-reported (i.e. breast satisfaction, relationship status, sexual satisfaction and experienced femininity) data was collected by independent trained research staff. The relationship between breast development, satisfaction and femininity was assessed. Control data on breast development and satisfaction in women without DSD was retrieved from the literature. MAIN RESULTS AND THE ROLE OF CHANCE: Of the 695 participants, 61% had received estrogen replacement and 51% puberty induction therapy, whereas 2% had received breast augmentation surgery. Approximately 65% of participants had reached Tanner breast stage 5, which is substantially less than the general population (90%). Breast satisfaction was lower than normative data as well (P < 0.001, Cohen's d = 0.45). Breast size and breast satisfaction were associated with feelings of femininity. LIMITATIONS, REASONS FOR CAUTION: Limitations include the sample representativeness (e.g. regarding the clinical heterogeneity) and the limited in-depth knowledge on (prior) hormonal regimens. Furthermore, no (matched) control data was collected as part of this study. WIDER IMPLICATIONS OF THE FINDINGS: In order to support the psychosexual well-being of women with DSD, enhancing breast development by sufficient hormone replacement and possible augmentation surgery is advocated. The scope of DSD management should be beyond genital development only and consider breasts as well.

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Section: Factors Associated With Breast Satisfactionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mental health of a large group of adults with disorders of sex development in six European countries

Vries¹,

Roehle²,

Marshall³

et al. 2020

ESPE

View full text Add to dashboard Cite

show abstract

Self- and proxy-reported outcomes after surgery in people with disorders/differences of sex development (DSD) in Europe (dsd-LIFE)

Grift

Schober

Hirschberg

et al. 2021

Journal of Pediatric Urology

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Breast development and satisfaction in women with disorders/differences of sex development

Grift

Kreukels

dsd-LIFE³

2019

Human Reproduction

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STUDY QUESTION What are the levels of breast development and satisfaction in women with a Disorder/Difference of Sex Development (DSD)? SUMMARY ANSWER Compared with normative data, women with DSD reached lower Tanner stages and reported less breast satisfaction. WHAT IS KNOWN ALREADY Women with DSD may have chromosomal and hormonal variations that can impact typical breast development. While much emphasis is placed on genital development in this group, little is known about breast development, satisfaction and their association. STUDY DESIGN, SIZE, DURATION Data collection was part of the cross-sectional European multicenter dsd-LIFE study. Fourteen recruiting sites included 1040 participants between February 2014 and September 2015. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 695 female-identifying participants were included (Turner n = 332, 46,XY DSD n = 141 and congenital adrenal hyperplasia n = 222), with a median age of 28 years. Clinical (i.e. history of hormone and surgical treatments, Tanner breast examination) and patient-reported (i.e. breast satisfaction, relationship status, sexual satisfaction and experienced femininity) data was collected by independent trained research staff. The relationship between breast development, satisfaction and femininity was assessed. Control data on breast development and satisfaction in women without DSD was retrieved from the literature. MAIN RESULTS AND THE ROLE OF CHANCE Of the 695 participants, 61% had received estrogen replacement and 51% puberty induction therapy, whereas 2% had received breast augmentation surgery. Approximately 65% of participants had reached Tanner breast stage 5, which is substantially less than the general population (90%). Breast satisfaction was lower than normative data as well (P < 0.001, Cohen’s d = 0.45). Breast size and breast satisfaction were associated with feelings of femininity. LIMITATIONS, REASONS FOR CAUTION Limitations include the sample representativeness (e.g. regarding the clinical heterogeneity) and the limited in-depth knowledge on (prior) hormonal regimens. Furthermore, no (matched) control data was collected as part of this study. WIDER IMPLICATIONS OF THE FINDINGS In order to support the psychosexual well-being of women with DSD, enhancing breast development by sufficient hormone replacement and possible augmentation surgery is advocated. The scope of DSD management should be beyond genital development only and consider breasts as well. STUDY FUNDING/COMPETING INTEREST(S) The study was funded by the European Union Seventh Framework Program (FP7/2007–2013) under grant agreement no. 305 373. There are no competing interests. TRIAL REGISTRATION NUMBER German Clinical Trials Register: Registration identification number: DRKS00006072.

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Morphologie mammaire dans le syndrome de Turner. Étude clinique prospective multicentrique de 21 cas

Cited by 5 publications

References 21 publications

Mental health of a large group of adults with disorders of sex development in six European countries

Mental health of a large group of adults with disorders of sex development in six European countries

Self- and proxy-reported outcomes after surgery in people with disorders/differences of sex development (DSD) in Europe (dsd-LIFE)

Breast development and satisfaction in women with disorders/differences of sex development

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