Morphologies, mechanical and <i>in vitro</i> behaviors of DLP-based 3D printed HA scaffolds with different structural configurations

Liu, Wang; Zhou, Qing; Zhang, Xueqin; Ma, Lili; Xu, Baohua; He, Rujie

doi:10.1039/d3ra03080f

Cited by 13 publications

(9 citation statements)

References 60 publications

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“…There are two types of scaffold designs based on the architecture: non-parametric and parametric (Figure 5) [44]. Non-parametric designs are based on traditional lattice geometries such as simple cubic, body-centred cubic (BCC), face-centred cubic (FCC) [45,46], octet, truncated octahedron [47], diamond, truncated cube [48], fluorite, kelvin cell [49], iso truss, re-entrant, Weaire-Phelan and honeycomb [50]. An advantage of non-parametric design is that the scaffolds are more accessible to manufacture due to their simple geometries, as they do not require specialised algorithms to generate.…”

Section: Types Of Designsmentioning

confidence: 99%

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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Three-dimensional porous scaffolds are substitutes for traditional bone grafts in bone tissue engineering (BTE) applications to restore and treat bone injuries and defects. The use of computational modelling is gaining momentum to predict the parameters involved in tissue healing and cell seeding procedures in perfusion bioreactors to reach the final goal of optimal bone tissue growth. Computational modelling based on finite element method (FEM) and computational fluid dynamics (CFD) are two standard methodologies utilised to investigate the equivalent mechanical properties of tissue scaffolds, as well as the flow characteristics inside the scaffolds, respectively. The success of a computational modelling simulation hinges on the selection of a relevant mathematical model with proper initial and boundary conditions. This review paper aims to provide insights to researchers regarding the selection of appropriate finite element (FE) models for different materials and CFD models for different flow regimes inside perfusion bioreactors. Thus, these FEM/CFD computational models may help to create efficient designs of scaffolds by predicting their structural properties and their haemodynamic responses prior to in vitro and in vivo tissue engineering (TE) applications.

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Section: Types Of Designsmentioning

confidence: 99%

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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“…Although research reporting the use of 3D-printed hydroxyapatite using VPP is limited, certain studies have illustrated that the resulting product exhibits increased precision and enhanced sensitivity and accuracy compared to alternative 3D printing technologies [48]. Hap 3Dprinted constructs have excellent bioactive properties, including increased biocompatibility, osteoinductivity, osteoconductivity, excellent bioresorbability and biodegradation, and near-to-zero cytotoxicity [49][50][51][52][53]. These qualities hold significant importance in medical applications such as tissue engineering for bone grafts [49][50][51]53], dental root implants [52], and coatings for 3D-printed metallic implants [54][55][56].…”

Section: Biomaterials Adapted To Vpp 3d Printingmentioning

confidence: 99%

“…Hap 3Dprinted constructs have excellent bioactive properties, including increased biocompatibility, osteoinductivity, osteoconductivity, excellent bioresorbability and biodegradation, and near-to-zero cytotoxicity [49][50][51][52][53]. These qualities hold significant importance in medical applications such as tissue engineering for bone grafts [49][50][51]53], dental root implants [52], and coatings for 3D-printed metallic implants [54][55][56].…”

Section: Biomaterials Adapted To Vpp 3d Printingmentioning

confidence: 99%

“…Good results have been obtained by employing Hap in the 3D printing of bone grafts for bone regeneration. It is known that the pore sizes and shapes of these builds are the main modulators for enhanced or diminished osteoconductive properties [51,53]. Research has demonstrated that larger pore sizes (exceeding 300 µm) enhance the osteogenesis process [57,58], although the challenge lies in achieving a balance between pore size and shape (with cubic pores being more efficient [50]) while maintaining the required mechanical performance [59].…”

Section: Biomaterials Adapted To Vpp 3d Printingmentioning

confidence: 99%

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Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

Timofticiuc,

Călinescu,

Iftime

et al. 2023

JFB

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Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality. Instead of developing completely new materials, an alternate approach to solving this problem involves adapting existing biomaterials. These materials are incompatible with VPP 3D printing in their pure form but can be adapted to the VPP chemistry and general process through the use of innovative mixtures and the addition of specific pre- and post-printing steps. This review’s primary objective is to highlight biofunctional and biocompatible materials that have been adapted to VPP. We present and compare the suitability of these adapted materials to different medical applications and propose other biomaterials that could be further adapted to the VPP 3D printing process in order to fulfill patient-specific medical requirements.

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“…UV curing technology has the advantages of being highly efficient, environmentally friendly, energy-saving, enabling, and economical, as well as having a shorter curing time [ 26 ]. The above advantages make it widely applicable for oxide ceramics (e.g., Al 2 O 3 , ZrO 2 ) [ 27 , 28 , 29 , 30 ] and bio ceramics (e.g., HA, TCP) [ 31 , 32 ]. The studies on slurry preparation [ 33 , 34 ], the optimization of VP process parameters [ 35 , 36 ], and debonding–sintering processes [ 37 , 38 ] for these ceramic materials have reached a mature stage and have been widely reported.…”

Section: Introductionmentioning

confidence: 99%

How to Improve the Curing Ability during the Vat Photopolymerization 3D Printing of Non-Oxide Ceramics: A Review

Gao,

Chen,

Chen

et al. 2024

Materials

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Vat photopolymerization (VP), as an additive manufacturing process, has experienced significant growth due to its high manufacturing precision and excellent surface quality. This method enables the fabrication of intricate shapes and structures while mitigating the machining challenges associated with non-oxide ceramics, which are known for their high hardness and brittleness. Consequently, the VP process of non-oxide ceramics has emerged as a focal point in additive manufacturing research areas. However, the absorption, refraction, and reflection of ultraviolet light by non-oxide ceramic particles can impede light penetration, leading to reduced curing thickness and posing challenges to the VP process. To enhance the efficiency and success rate of this process, researchers have explored various aspects, including the parameters of VP equipment, the composition of non-oxide VP slurries, and the surface modification of non-oxide particles. Silicon carbide and silicon nitride are examples of non-oxide ceramic particles that have been successfully employed in VP process. Nonetheless, there remains a lack of systematic induction regarding the curing mechanisms and key influencing factors of the VP process in non-oxide ceramics. This review firstly describes the curing mechanism of the non-oxide ceramic VP process, which contains the chain initiation, chain polymerization, and chain termination processes of the photosensitive resin. After that, the impact of key factors on the curing process, such as the wavelength and power of incident light, particle size, volume fraction of ceramic particles, refractive indices of photosensitive resin and ceramic particles, incident light intensity, critical light intensity, and the reactivity of photosensitive resins, are systematically discussed. Finally, this review discusses future prospects and challenges in the non-oxide ceramic VP process. Its objective is to offer valuable insights and references for further research into non-oxide ceramic VP processes.

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Morphologies, mechanical and in vitro behaviors of DLP-based 3D printed HA scaffolds with different structural configurations

Abstract: In the field of bone engineering, porous ceramic scaffolds are in great demand for repairing bone defects.

Cited by 13 publications

References 60 publications

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

How to Improve the Curing Ability during the Vat Photopolymerization 3D Printing of Non-Oxide Ceramics: A Review

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