Morphologische Befunde bei Paraquatvergiftungen

Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura.

“…Characteristic morphological features of the paraquat lung were established by previous authors (Bullivant 1966;Toner et al 1970;Borchard et al 1974;Poche 1974). When the patient survived the peracute phase of intoxication, pulmonary fibrosis of various forms and severities is inevitable.…”

“…Although morphological features of the lung in our case were mostly similar to those in the previous reports, some were conspicuous to be mentioned. Inflammatory and exudative changes of alveolar walls may possibly be attribut able to the specific effect of paraquat on the alveolar walls of human lungs (Borchard et al 1974;Poche 1974). Bowden and Wyatt (1975) pointed out the importance of vascular injury in the pathogenesis of pulmonary firosis, irrespective of the causative factors.…”

“…cerebral purpura; paraquat poisoning; pulmonary fibrosis; autopsy Paraquat (GramoxoneR), one of the widely used herbicides, is known to cause peculiar lesions in the human and animal lungs and to have a systemic toxicity as well. Many autopsy records of paraquat poisoning ever reported have elucidated a life threatening progressive pulmonary fibrosis resulting, sooner or later, in severe respiratory failure (Matthew et al 1968;Borchard et al 1974;Poche 1974). The present case report dealing with autopsy findings of acute paraquat poisoning manifesting the characteristic pulmonary lesions was provided to link consecutive pathological features of fibrosis of the paraquat lung.…”