Morphologische und experimentelle Untersuchungen an alternden Hunden

Extrinsic and intrinsic blood supply and histomorphological changes associated with age in the cerebral arteries and brain nuclei in dog (Canis familiaris) and pig (Sus scrofa domestica)

“…This was based on his findings that with age there was considerable loss of the purkinje cells of human which in turn affected the motor strength and skill. Similar studies to indicate loss of purkinje cells with age have been carried out by Harms (1924) and Inukai (1928). Sulkin (1955) …”

“…Muhlmann (1910) noted the increase in the accumulation of lipoidal granules in the neurons with advancing age in man and the guinea pig. Dcllsy (1911) reported the presence of the pigment in purkinje cells of the cerebellum of the dog, Ellis (1920) in the dentate nucleus of the human, and Harms (1924) in the cerebellum of the dog. The occurrence of the pigment in different parts of the nervous tissue was investi gated by Bethe and Pluck (1937; in ganglionic cells) and Andrew (1941; in the trigeminal ganglion, spinal cord and brain of the mouse).…”

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

“…Hodge (1894), for example, demonstrated that the spinal ganglia of man accumulate more pigments than other areas studied. Harms (1924) showed marked accumulation.…”

The occurrence of lipofuscin pigment as related to aging in the lumbar spinal cord, dorsal root ganglia and paravertebral ganglia of the dog and pig

“…The ganglion cells of the sympathetic system were especially involved. Harms (1924) found heavy accumulations of pigment in the pyramidal cells of the cerebrum. Sulkin In recent studies of the dog and hog brain (Whiteford, 1964, andGetty, 1966), it was found that lipofuscin was absent in the neurons of animals under one year of age and that it was universally present in old animals.…”

“…There are a few reports of studies on the dog (Dolley, 1911;Goodpasture, 1918;Harms, 1924; Sulkin and Kuntz, 1952; Sulkin, 1953Sulkin, , 1955aSulkin, , 1955b; Whiteford, 1964;and Whiteford and Getty, 1966). There are only two reports of age studies on the nervous system of the pig, both dealing with age changes in various brain stem nuclei (Whiteford, 1964, andGetty, 1966).…”