Morphologische Veränderungen der medikamenteninduzierten Leberschädigung

Antiproliferative Triterpenes from the Leaves and Twigs of Juglans sinensis on HSC-T6 Cells

“…33,34 The inhibitory activity of compounds 1-21 on the proliferation of activated HSC-T6 cells was evaluated (see Supporting Information, S36). These compounds consisted of oleanane type (1, 2, 5-12), ursane type (3,4,(13)(14)(15)(16)(17)(18)(19), and lupane type (20,21), according to their aglycone moieties (see Supporting Information, S1). Substitutions such as OH (1-21), carboxyl (5-9, 12-17, and 19), oxo (1, 2, 8, 9, and 17), and glucopyranoside (1, 3, 4, 10, 11, and 18) also divided them into several groups.…”

“…Liver fibrosis results from chronic hepatocellular damage in response to viral infection, alcoholic poisoning, drug-induced toxicity, or any other factors that cause damage to hepatocytes. − The process to liver fibrosis is generally characterized by increased extracellular matrix (ECM) deposition and reduced matrix degradation . In the pathogenesis of liver fibrosis, hepatic stellate cells (HSCs) are the primary cellular source responsible for the excess production of ECM proteins .…”