Morphology and growth control of griseofulvin recrystallized by compressed carbon dioxide as antisolvent

Gioannis, Barbara De; Jestin, P.; Subra, P.

doi:10.1016/j.jcrysgro.2003.10.025

Cited by 59 publications

(45 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-solvent methods have been used extensively in the synthesis of sub-micron and micron size particles of insoluble drug moieties [6,7]. The formation, stabilization and sedimentation of these particles depend upon the discreet steps of nucleation, condensation and coagulation into larger particles [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Meng

Chen

Chowdhury

et al. 2009

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Meng

Chen

Chowdhury

et al. 2009

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…As the stirring rate increased to 500 rpm, bipyramidal shape particles were produced with length 360-550 μm and width of 171-180 μm. The increase in stirring rate lead to both a switch in morphology from needles to bipyramid (33). Warwick et al reported that the expansion rate of the solution in the GAS process was found to have a significant effect on the morphology of the particles produced.…”

Section: Introductionmentioning

confidence: 99%

Increasing the Dissolution Rate of Itraconazole Processed by Gas Antisolvent Techniques using Polyethylene Glycol as a Carrier

2007

View full text Add to dashboard Cite

show abstract

“…Moreover, pressure also influences the andro- grapholide morphology; slice-like and column-like, but the change of morphology does not relate with polymorphs, because slice-like and column-like particles exhibited similar XRD patterns as shown in Figure 7a. Therefore, the change of morphology depends on the relative growth of a specific face, for example, column-like particles have an elongated growth in the vertical direction whereas slice-like particles grow in the horizontal direction (Gioannis et al, 2004).…”

Section: Pressure Effectmentioning

confidence: 99%

“…This method of particle formation is based on two simultaneous mechanisms; the supercritical fluid penetrates the droplets while the organic solvent evaporates into the supercritical fluid; the resulting fast supersaturation produces micro or nano particles (Gioannis et al, 2004;Mukhopadhyay and Dalvi, 2004). Carbon dioxide is the most commonly used SAS, because it has a relatively low critical temperature and pressure (304.2 K and 7.39 MPa; Smith et al, 2001), non-toxic, non-flammable, noncorrosive, inert, and inexpensive (Imsanguan et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Precipitation of pharmaceuticals using a supercritical anti‐solvent (SAS) dechnique: A preliminary study

et al. 2010

View full text Add to dashboard Cite

The aims of this research were to investigate the applicability of the supercritical anti-solvent (SAS) process on the precipitation of pharmaceuticals (andrographolide and acetaminophen). In particular, the goal of this research was to study the influence of pressure at 10 and 24 MPa on particle characteristics (morphology, crystalline structure, polymorphic form, size, size distribution, and precipitation yield), and to compare the precipitation efficiency of SAS process and evaporation process. Scanning electron microscope (SEM), X-ray diffraction (XRD), and high performance liquid chromatography (HPLC) showed a significant change in particle size, size distribution, morphology, and precipitation yield, respectively. From an analysis of the results it was found that the crystal size of andrographolide and acetaminophen decreased with increasing pressure. The morphology of andrographolide particles changed from slice-like to column-like when the pressure was increased. On the other hand, the acetaminophen particles obtained were found to be monoclinic form (I) under both operating pressures. The SAS process produced small uniform shaped crystals, with a narrow size distribution, high precipitation yield and selective precipitation were also observed. L'objectif de cette recherche est d'examiner si le procédé par antisolvant supercritique (ASS) est applicableà la précipitation de produits pharmaceutiques (andrographolide et acétaminophène) et d'évaluer l'influence des pressions de service (10 MPa et 24 MPa) sur la morphologie, la taille des particules, la répartition deséléments et le rendement de précipitation. Le rendement de précipitation du procédé par ASS aégalement eté comparéà celui du procédé parévaporation. La microscopieélectroniqueà balayage (MEB) associée au logiciel Image-Pro Plus, la diffractométrie de rayons X (DRX) et la chromatographie liquideà haute performance (CLHP) ont montré des différences importantes sur le plan de la morphologie, de la taille des particules, de la répartition des tailles et du rendement de précipitation, respectivement. Les résultats semblent indiquer que la taille des cristaux d'andrographolide et d'acétaminophène diminue lorsque la pression augmente. La morphologie des particules d'andrographolide est passée d'une forme de strateà une forme de colonne avec l'augmentation de la pression. En revanche, selon les résultats, les particules d'acétaminophène obtenues ont une forme monoclinique (I) avec les deux pressions de service. Le procédé par ASS produit des cristaux uniformes, des particules de petite taille, une faible répartition des particules, un rendement de précipitationélevé ainsi qu'une précipitation sélective.

show abstract

Morphology and growth control of griseofulvin recrystallized by compressed carbon dioxide as antisolvent

Cited by 59 publications

References 21 publications

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Increasing the Dissolution Rate of Itraconazole Processed by Gas Antisolvent Techniques using Polyethylene Glycol as a Carrier

Precipitation of pharmaceuticals using a supercritical anti‐solvent (SAS) dechnique: A preliminary study

Contact Info

Product

Resources

About