Morphology and Mechanical, Corrosive, and Antibacterial Behaviors of Indirectly Extruded Zn-0.05wt.%Mg-(0.5, 1 wt.%)Ag Alloys

Xiao, Chi; Zhao, Dewei; Sun, Quanxiang; Su, Yishi; Cui, Daping; Zhang, X. Z.; Dong, Xiaoxv; Wang, H. X.; Wang, F.; Ren, Yuping; Qin, Gaowu

doi:10.1007/s11665-019-04297-4

Cited by 15 publications

(11 citation statements)

References 40 publications

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“…Ag has a high solubility in Zn (8 wt% at 431°C). Therefore, the increase in the hardness is mainly ascribed to the solid solution strengthening of Ag in Zn‐0.05Mg alloy, as examined from our previous article (Xiao et al, 2019). There is no detectable phased related to Ag compound appeared in the X‐ray diffraction patterns and the morphological images except Mg 2 Zn 11 phase.…”

Section: Resultsmentioning

confidence: 80%

“…Generally, the requirement for ultimate tensile strength, yield strength, and elongation has been recognized. The addition of Ag enhanced the tensile strength greatly and reduced tensile strain, in addition to improving the antibacterial performance of Zn‐Mg alloy (Xiao et al, 2019). Since the compressive strength is another vital parameter for evaluating the loading resistance, the compression test was performed on the as extruded alloys.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the very high solubility of Ag in Zn, the addition of Ag contributed to the increased strength of Zn‐0.05Mg alloy via solid solution strengthening. The tensile properties of Zn‐0.05Mg alloy have been improved by adding of Ag and investigated in our previous article (Xiao et al, 2019). The Zn‐Mg‐Ag alloy also showed excellent antibacterial property.…”

Section: Discussionmentioning

confidence: 99%

“…AgNP coating of PyCs had significantly improved their cytocompatibility to fibroblast and peripheral blood mononuclear (PBM) cells when compared with untreated controls (Angelina, Narayani, Ganesan, Panicker, & Jagadeesan, 2019). Recently, we have manufactured Zn‐Mg‐Ag alloys with good strength and high antibacterial performance (Xiao et al, 2019). However, the biocompatibility of Ag including Zn alloys has rarely been reported (Li et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

Xiao

Zhu

et al. 2020

J Biomed Mater Res

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Zn alloys are emerging as promising degradable biomedical materials due to their tailorable mechanical properties and moderate biodegradable rate, compared with conventional biodegradable metallic materials. Ag, as an effective antibacterial and reinforcing element, was incorporated into Zn‐0.05Mg alloys. In the present work, the effects of the Ag addition on mechanical, cytotoxic, hemolytic, pyrogenic, histological behaviors of the animal were investigated. The compressive yielding strength is enhanced from 198 MPa for Zn‐0.05Mg alloy up to 224 and 234 MPa for Zn‐0.05Mg‐0.5Ag and Zn‐0.05Mg‐1Ag alloys, respectively. When the compressive strain was 65%, the strength of the Zn‐0.05Mg‐1.0Ag alloy reached 833 MPa, which was much higher than that of 721 MPa for Zn‐0.05Mg alloy. The relative growth rate (RGR) for the extracts of Zn‐0.05Mg‐1Ag alloy with the concentrations of 10, 50, and 100% after 5 days incubation reaches 98.5, 95.2, and 94.2%, which are higher than those in extracts of Zn‐0.05Mg‐0.5Ag alloy (98.2, 93.9, 92.1%). The hemolysis rate of the Zn‐0.05Mg alloys with 0.5 and 1 wt% Ag is 2.46 and 2.28%, respectively. The variations of body weight and temperature, postinjection symptoms, pathological morphologies of the visceral organs demonstrate that the alloys are nontoxic according to the toxicity rating standards. Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys are experimentally safe materials and promising for the future application as biodegradable medical devices.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

Xiao

Zhu

et al. 2020

J Biomed Mater Res

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“…27 Similarly, the antibacterial property of the Zn-Mg-Ag alloys enhanced with the increase of silver content. 58 The greater the amount of active silver ions are released, the more effective the antibacterial properties would be. 59 Therefore, the increase of silver content in Zn-Ag alloy may potentially increase the release of silver, which in turn improve the antibacterial properties, possibly just as reported previously in Mg-Ag alloys.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

Advances on biodegradable zinc-silver-based alloys for biomedical applications

Liu

Shao

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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The biodegradable metals have great potential for the biomedical applications, which could be gradually degraded, absorbed, or excreted in the human body, avoiding the removal though secondary surgery. Zinc-based alloys are novel series of degradable metals for medical applications, and they are gaining lots of attention in the research field of absorbable metals. Zinc-silver (Zn-Ag) alloys show superior mechanical strength, good biodegradability, biocompatibility, and antibacterial properties, which render them to be potential candidates for biomedical applications. In this paper, we reviewed the development of Zn-Ag alloys in terms of mechanical properties, degradabilities, biocompatibilities, antibacterial properties, and potential applications in dentistry.

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In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay

et al. 2022

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In vitro cytotoxicity assessment is indispensable in developing new biodegradable implant materials. Zn, which demonstrates an ideal corrosion rate between Mg-and Fe-based alloys, has been reported to have excellent in vivo biocompatibility. Therefore, modifications aimed at improving Zn's mechanical properties should not degrade its biological response. As sufficient strength, ductility and corrosion behavior required of load-bearing implants has been obtained in plastically deformed Zn-3Ag-0.5Mg, the effect of simultaneous Ag and Mg additions on in vitro cytocompatibility and antibacterial properties was studied, in relation to Zn and Zn-3Ag. Direct cell culture on samples and indirect extract-based tests showed almost no significant differences between the tested Zn-based materials. The diluted extracts of Zn, Zn-3Ag, and Zn-3Ag-0.5Mg showed no cytotoxicity toward MG-63 cells at a concentration of ≤12.5%. The cytotoxic effect was observed only at high Zn 2+ ion concentrations and when in direct contact with metallic samples. The highest LD 50 (lethal dose killing 50% of cells) of 13.4 mg/L of Zn 2+ ions were determined for the Zn-3Ag-0.5Mg. Similar antibacterial activity against Escherichia coli and Staphylococcus aureus was observed for Zn and Zn alloys, so the effect is attributed mainly to the released Zn 2+ ions exhibiting bactericidal properties. Most importantly, our experiments indicated the limitations of water-soluble tetrazolium salt-based cytotoxicity assays for direct

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Morphology and Mechanical, Corrosive, and Antibacterial Behaviors of Indirectly Extruded Zn-0.05wt.%Mg-(0.5, 1 wt.%)Ag Alloys

Cited by 15 publications

References 40 publications

Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

Mechanical performance and biocompatibility assessment of Zn‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys

Advances on biodegradable zinc-silver-based alloys for biomedical applications

In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay

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