Morphology and Nutrition of Chloridium chlamydosporis (Bisporomyces chlamydosporis)

Omvik, Aasa

doi:10.2307/3757580

Cited by 2 publications

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References 8 publications

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“…C. virescens var. chlamydosporum is most commonly isolated from wood in advanced stages of decay and from forest soils rich in organic matter. , The fungus was one of five Hyphomycetes shown to increase in frequency with the decomposition of fallen logs of Picea glauca that were also colonized by Basidiomycetes . There are no prior reports of chemistry from this species and only one report of chemistry from any member of the genusan unrelated compound described from an unidentified Chloridium spp …”

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Chloriolide, a 12-Membered Macrolide from Chloridium virescens var. chlamydosporum (NRRL 37636)

et al. 2006

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A new 12-membered macrolide (chloriolide; 1) was obtained from solid-substrate fermentation cultures of Chloridium virescens var. chlamydosporum that was originally isolated from decayed wood. The structure of 1 was determined by analysis of 1D NMR, 2D NMR, and MS data and confirmed by X-ray crystallographic analysis. The absolute configuration of 1 was assigned by application of the modified Mosher method using the (R)- and (S)-MTPA derivatives of a rearrangement product obtained under standard acylation conditions. The assignment made by analysis of the corresponding Deltadelta values was verified by X-ray crystallographic analysis of the (S)-MTPA derivative.

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Chloriolide, a 12-Membered Macrolide from Chloridium virescens var. chlamydosporum (NRRL 37636)

et al. 2006

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“…Chloridium virescens var. chlamydosporum is most commonly isolated from wood in advanced stages of decay and from forest soils rich in organic matter 84,85. To our knowledge, there are no prior reports of chemistry from this species, although one unrelated compound has been described from an unidentified Chloridium spp 86.…”

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Chemical investigations of freshwater and fungicolous fungi

Jiao¹

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Fungi are well-known to produce a tremendous variety of bioactive secondary metabolites which play important roles as pharmaceuticals and agrochemicals. In contrast to random-screening approaches utilized in industry, our research applies ecology-based strategy to the selection of fungi for chemical studies. The research described here involves the chemical investigation of freshwater and fungicolous fungi as producers of novel metabolites with potential practical value. Freshwater fungi, as a distinctive ecological group, have only recently been studied in any depth, and remain underexplored in comparison with other fungal niche groups. Chemical studies of freshwater fungal isolates in our research group have led to the discovery of a variety of new bioactive metabolites, suggesting significant untapped potential among these organisms. Studies in this area described in this thesis led to the discovery of twenty-two new metabolites, many of which display significant antibacterial and/or antifungal activities. Some of these compounds possess novel structural features, such as new ring systems. Mycoparasitic and fungicolous fungi are those that colonize other fungi and could be viewed as potential producers of antifungal agents because of the negative effects they often exert on their hosts. Bioassay-guided fractionation of extracts from cultures of selected mycoparasitic and fungicolous fungal isolates afforded twenty-five new compounds representing diverse structural types. Most of these compounds display biological activity, with some showing antifungal and/or antiinsectan effects. The new secondary metabolites isolated during these studies represent a variety of different biosynthetic classes, including cyclic depsipeptides, nucleosides, polyketides, macrolides, terpenoids, and compounds with mixed biogenetic origin. Their structures were established by analysis of MS and NMR data, chemical degradation or derivatization reactions, and/or X-ray diffraction analysis data. Absolute configuration ACKNOWLEDGMENTS I would like to express my sincere appreciation to my research adviser, Professor James B. Gloer, for his valuable guidance, patience, motivation, encouragement, and support during my studies at the University of Iowa. I would also like to thank Dr. Katherine B. Gloer for helping with my thesis and Gloer group members for their friendship and help.

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Morphology and Nutrition of Chloridium chlamydosporis (Bisporomyces chlamydosporis)

Cited by 2 publications

References 8 publications

Chloriolide, a 12-Membered Macrolide from Chloridium virescens var. chlamydosporum (NRRL 37636)

Chloriolide, a 12-Membered Macrolide from Chloridium virescens var. chlamydosporum (NRRL 37636)

Chemical investigations of freshwater and fungicolous fungi

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