Morphology biased pharmacological and mechanical properties of nanosized block copolymers of PNIPAM with polyethylene oxide and polyaminoacids in presence of polycaprolactone

Abstract

This work targets to develop amphiphilic self‐assembled PEO‐b‐PAAs‐b‐PNIPAM and PEO‐b‐PAAs‐b‐PNIPAM@PCL nanosized block copolymers (NBCPs) of poly N‐isopropyl acrylamide (PNIPAM) with polyethylene oxide (PEO), and poly amino acids (PAAs) with and without polycaprolactone (PCL) via ring‐opening and condensation polymerization methods. The interesting ring necklace and petunia bell‐shaped flower‐like morphology play an important role in both mechanical behavior and pharmacological actions. The PEO‐b‐PAAs‐b‐PNIPAM@PCL NBCP exhibits a notable antibacterial activity against gram‐negative (Escherichia coli) and gram‐positive (Staphylococcus aureus) with ZOI of 20 ± 4 mm and 18 ± 3 mm, respectively, with MIC 250 μg/ml. The mechanical properties of the NBCPs are measured at room temperature. The PEO‐b‐PAAs‐b‐PNIPAM@PCL NBCP possesses a higher value in each case compared to the neat polymer with the UTS 1.4651 MPa, Y 0.0050 MPa, Tensile strength at yield (1.4048 MPa), TS at break (1.4640 MPa), % elongation at yield (23.5%), elongation % at break (124%) and proportional limit (1.0082 MPa at 8%), respectively. With the improved mechanical strength, effective antibacterial activities along with sustainable drug release rate, the designed material can be used as a potential material for different biomedical applications.

Carbon-reinforced Polymer Nanocomposites Against Infectious Diseases

“…The proper selection of carbon-based filler materials with a bioactive polymer matrix with additional biocomponents will be highly effective in developing natural or modified carbonreinforced hybrid polymer composites for dealing with infectious diseases by suppressing antimicrobial resistivity. [69][70][71][72] However, some challenges that are yet to be solved can be overcome by a better understanding of the science behind carbon fillers, polymer matrix, their combination, incorporation of other natural molecules, their interaction, and morphology. The mechanisms, pathways, and the participation of CRPNCs in the inhibition of microbe growth by damaging the microbe cell wall and DNA destruction are shown in Figure 1.5.…”