Morphology design of polymer microneedle arrays: Key factors from the application perspective

Jia, Baoling; Xia, Tiandong; Wang, Xiaohui; Xu, Yangtao; Guo, Zhenyu

doi:10.1016/j.jddst.2023.104883

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.104883

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Morphology design of polymer microneedle arrays: Key factors from the application perspective

Baoling Jia,

Tiandong Xia,

Xiaohui Wang

et al.

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2024

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Cited by 3 publications

References 269 publications

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A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates

Jia,

Xia,

Wang

et al. 2024

Polymers for Advanced Techs

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Microneedle (MN) has significant potential for transdermal glucose monitoring. However, challenges remain in selecting suitable materials for long‐acting monitoring MN. In this study, precise solid UV‐curable resin MN patches were fabricated using a synergistic combination of the micromolding method and the UV‐curing procedure, as an alternative to the previous 3D printing. The properties of the UV‐cured resin MN patches prepared using this method were evaluated and characterized, focusing on their potential for long‐acting monitoring. The results demonstrated that the UV‐curable resin MN patches exhibited superior shape stability, very low cytotoxicity, minimal skin irritation, and a fracture force of approximately 2.289 N/needle. Following immersion in 37°C PBS for different days, the shape and mass changed negligibly, and the fracture force still reached half of the original values after 21 days. UV‐curable resin is a highly promising substrate for MN, and the study provides a new material selection strategy for long‐acting monitoring of MN development.

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A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates

Jia,

Xia,

Wang

et al. 2024

Polymers for Advanced Techs

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Microneedle Optimization: Toward Enhancing Microneedle's Functionality and Breaking the Traditions

Lori Zoudani,

Nguyen,

Kashaninejad

2024

Small Structures

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Microneedles hold remarkable potential for providing convenient and unique solutions for disease diagnosis and therapy. However, their integration into clinical practices has been slow, primarily due to the challenge of developing models that meet the criteria of a particular application. A comprehensive and systematic analysis of all aspects of microneedle platforms is imperative to overcome this bottleneck. The analysis involves gathering performance‐related information and understanding the factors affecting the functionality of microneedles. The performance of microneedles is heavily influenced by parameters such as dimensions, needle shape, array arrangement, and materials (flexible, stretchable, stimuli‐responsive, biodegradable). This article presents a fresh perspective on microneedles, introducing concepts toward optimal designs across various microneedle platforms. This includes application, design, fabrication techniques, and understanding how a specific microneedle design can effectively meet the requirements of a particular application. By addressing these crucial issues, further advancement of microneedle technology occurs.

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Investigation of biosensing properties in magnetron sputtered metallized UV-curable polymer microneedle electrodes

Jia,

Xia,

Wang

et al. 2024

Journal of Biomaterials Science, Polymer Edition

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Morphology design of polymer microneedle arrays: Key factors from the application perspective

Cited by 3 publications

References 269 publications

A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates

A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates

Microneedle Optimization: Toward Enhancing Microneedle's Functionality and Breaking the Traditions

Investigation of biosensing properties in magnetron sputtered metallized UV-curable polymer microneedle electrodes

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