Morphology discrimination in implantable cardioverter-defibrillators: consistency of template match percentage during atrial tachyarrhythmias at different heart rates

Abstract

Morphology discrimination has a consistently high template match percentage during SVTs, which is independent of ventricular CL. The consistent high match percentage results in high specificity for arrhythmia discrimination.

Arrhythmia discrimination by physician and defibrillator: Importance of atrial channel

“…Awareness of the problem has prompted development of new algorithms [3] aimed at improved distinction of supraventricular tachyarrhythmias (SVT) -the main cause of inappropriate shocks -in order to increase specificity of arrhythmia detection while maintaining sensitivity. Conflicting data exist regarding the relative merits of dual-chamber and single-chamber ICD [4][5][6][7][8][9]. Several authors have stressed the potential utility of adjusting individual patients' ICD detection criteria based on past arrhythmias [4].…”

Recommendations for the Programming of Implantable Cardioverter-Defibrillators in New Zealand

“…Limited data suggest ventricular electrogram morphology alone or in combination with stability provides the best SVT-VT discrimination for initial detection of VT [45] but that morphology alone may result in limited sensitivity for VT detection [46,47]. It is this risk of under-detecting VT that tempers the systematic enabling of discriminators.…”

Cartilage Extracellular Matrix Integrity and OA

“…The G1 domain is attached to a link protein that enables multipl e a g g r e c a n s u b u n i t s t o b i n d t o a l o n g nonsulfated glycosaminoglycan backbone known as hyluronic acid (HA). Thus aggrecan becomes trapped within the collagen network where some suspect that it acts to physically shield type II collagen from proteolytic cleavage (Pratta et al, 2003 (Julovi et al, 2004;Wang et al, 2006;Theuns et al, 2008) while the opposite effect has been found to occur in the presence of smaller mass species (20 kDa) of this proteoglycan. Additionally, these larger species can also inhibit proteoglycan release from cartilage tissue ECM.…”