Morphology, energetics and growth kinetics of diphenylalanine fibres

Rodger, P. Mark; Montgomery, Caroline; Costantini, Giovanni; Rodger, Alison

doi:10.1039/d0cp05477a

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…We have previously seen with diphenyl alanine 47 that the process of forming self-assembled structures may vary from experiment to experiment depending as it does on nucleation events. We therefore performed extensive experiments as a function of time and concentration of the monomer.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Linear Dichroism Activity of Chiral Poly(p-Aryltriazole) Foldamers

et al. 2021

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Controllable higher-order assembly is a central aim of macromolecular chemistry. An essential challenge to developing these molecules is improving our understanding of the structures they adopt under different conditions. Here, we demonstrate how flow linear dichroism (LD) spectroscopy is used to provide insights into the solution structure of a chiral, self-assembled fibrillar foldamer. Poly(para-aryltriazole)s fold into different structures depending on the monomer geometry and variables such as solvent and ionic strength. LD spectroscopy provides a simple route to determine chromophore alignment in solution and is generally used on natural molecules or molecular assemblies such as DNA and M13 bacteriophage. In this contribution, we show that LD spectroscopy is a powerful tool in the observation of self-assembly processes of synthetic foldamers when complemented by circular dichroism, absorbance spectroscopy, and microscopy. To that end, poly(paraaryltriazole)s were aligned in a flow field under different solvent conditions. The extended aromatic structures in the foldamer give rise to a strong LD signal that changes in sign and in intensity with varying solvent conditions. A key advantage of LD is that it only detects the large assemblies, thus removing background due to monomers and small oligomers.

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Section: ■ Results and Discussionmentioning

confidence: 99%

“…LD of Polymers as a Function of Water. Typical flow LD spectra collected in a microvolume Couette flow cell 47,48 are shown in Figures 3 and S5−S7. The signs and shapes of the LD spectra are independent of the foldamer concentration between 1 and 10 μM but change as a function of the water content.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Linear Dichroism Activity of Chiral Poly(p-Aryltriazole) Foldamers

et al. 2021

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“…Several reprecipitation- or evaporation-based methods have been devised for the preparation of FF microstructures such as nanospheres, fibers, , tubes, , and branches, determined by molecular kinetics and thermodynamics. To obtain greater structural diversity, directed crystal growth approaches that exploit electric fields, evaporative menisci, , or microfluidic channels , have been developed.…”

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Three-Dimensional Printing of Dipeptides with Spatioselective Programming of Crystallinity for Multilevel Anticounterfeiting

et al. 2022

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The functionalities of peptide microstructures and nanostructures can be enhanced by controlling their crystallinity. Gaining control over the crystallinity within the desired structure, however, remains a challenge. We have developed a three-dimensional (3D) printing method that enables spatioselective programming of the crystallinity of diphenylalanine (FF) dipeptide microarchitectures. A femtoliter ink meniscus is used to spatially control reprecipitation self-assembly, enabling the printing of a freestanding FF microstructure with programmed shape and crystallinity. The self-assembly crystallization of FF can be switched on and off at will by controlling the evaporation of the binary solvent. The evaporation-dependent crystallization was theoretically studied by the numerical simulation of supersaturation fields in the meniscus. We found that a 3D-printed FF microarchitecture with spatially programmed crystallinity can carry a 3D digital optical anisotropy pattern, applicable to generating polarizationencoded anticounterfeiting labels. This crystallinity-controlled additive manufacturing will pave the new way for facilitating the creation of peptide-based devices.

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Interfacial Assembly of Peptide Carbon Dot Hybrids Enables Photoinduced Electron Transfer with Improved Photoresponse

Mondal,

Umesh,

Hazra

et al. 2024

Langmuir

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Assemblies at the interface represent a powerful tool for integrating organic and inorganic components into hybrid nanostructures. Carbon dots are both excellent electron donors and acceptors, offering opportunities for their potential uses in light-harvesting applications. To further improve their functions, integration of acceptor carbon dots into donor organic nanostructures is of great interest for improving photophysical properties useful for photoinduced electron transfer. Here, a one-step protocol for the interfacial assembly of a two-component hybrid consisting of carbon dots and perylene containing an L-phenylalanine-based dipeptide through noncovalent bonding is developed. The perylene-containing dipeptide derivative formed micrometer-long nanofibers on the water surface through J-aggregate formation. Spectroscopic studies reveal photoluminescence quenching of the donor dipeptide upon increasing the concentration of acceptor carbon dots in the hybrid, suggesting photoinduced electron transfer from the donor peptides to acceptor carbon dots. The hybrids integrated in a planar device architecture show a significantly improved photoresponse because of the favorable interactions between the donor−acceptor components. The one-step integration of donor−acceptor hybrids on the water surface offers opportunities for light harvesting and related applications.

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Morphology, energetics and growth kinetics of diphenylalanine fibres

Abstract: Diphenylalanine (FF) has been shown to self-assemble from water into heterogeneous fibres that are among the stiffest biomaterials known. How and why the fibres form has, however, not been clear....

Cited by 3 publications

References 41 publications

Linear Dichroism Activity of Chiral Poly(p-Aryltriazole) Foldamers

Linear Dichroism Activity of Chiral Poly(p-Aryltriazole) Foldamers

Three-Dimensional Printing of Dipeptides with Spatioselective Programming of Crystallinity for Multilevel Anticounterfeiting

Interfacial Assembly of Peptide Carbon Dot Hybrids Enables Photoinduced Electron Transfer with Improved Photoresponse

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