Morphology of Acute Pancreatitis

Foulis, A. K.

doi:10.1007/978-3-642-77437-9_5

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the periductal inflammation that occurs with gallstone and alcohol-associated pancreatitis, patients who develop pancreatitis after an ischemic insult (hypotension, hypothermia, cardiac failure) show histologic evidence of peripheral perilobular inflammation. The progression to panlobular coagulative necrosis is the result of pancreatic infarction following venous and arterial thrombosis [21]. There is now considerable clinical and experimental evidence to suggest that pancreatic ischemia during the early phase of acute pancreatitis is important in the development of pancreatic necrosis [17,22].…”

Section: Pancreatic Eventsmentioning

confidence: 99%

Metabolic Management of Severe Acute Pancreatitis

Windsor

Hammodat

2000

World j. surg.

View full text Add to dashboard Cite

The metabolic management of severe acute pancreatitis involves early identification of patients with severe pancreatitis, aggressive fluid resuscitation, organ support, and careful monitoring in an intensive care environment. Recent evidence has helped to define the roles of enteral feeding, prophylactic antibiotics, endoscopic retrograde cholangiopancreatography, computed tomography, and fine-needle aspiration for bacteriology. The most difficult decision in the management of these patients is whether surgery is required and which of the complementary approaches to necrosectomy and drainage is appropriate. Key metabolic events in the acinar cell, pancreas, and intestines are now being unraveled, as is the basis for the systemic manifestations and organ dysfunction associated with pancreatitis. This gives hope for the development of more specific metabolic interventions, which will likely target the maintenance of intestinal integrity and function, preservation of pancreatic microcirculation, and balanced modulation of the inflammatory response.

show abstract

Section: Pancreatic Eventsmentioning

confidence: 99%