Morphology of adenocarcinomain situ of the uterine cervix: A study of 14 cases

Gloor, E; Ruzicka, J.

doi:10.1002/1097-0142(19820115)49:2<294::aid-cncr2820490215>3.0.co;2-g

Cited by 55 publications

(16 citation statements)

References 12 publications

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“…8). This pleomorphic type of AIS has been described previously with or without concurrent invasion 4, 5, 7. Because cells of this AIS variant simulate those sometimes found in early invasive glands, it is tempting to speculate that they have an increased invasive potential.…”

Section: Discussionmentioning

confidence: 60%

“…Including cases in the current study, the mean patient age in 205 cases of early invasive adenocarcinoma is 43.0 years 10–12, 16. The mean patient age in 301 cases of AIS is 37.8 years,4, 8, 17–24 suggesting an average time span of approximately 5 years in the transition from AIS to invasive adenocarcinoma of the cervix. However, because early invasive lesions may be more easily detected clinically than AIS, this time span probably underestimates the true mean interval in the progression from AIS to invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Adenocarcinoma of the cervix is increasing in incidence worldwide, particularly in younger women 1, 2. The histopathologic appearance and anatomic extent of uterine cervical adenocarcinoma in situ (AIS) are well characterized 3–8. There are, however, few detailed analyses of cases with early stromal invasion 9–12.…”

mentioning

confidence: 99%

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Early invasive adenocarcinoma of the cervix

Lee

Flynn

2000

Cancer

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Early invasive adenocarcinoma of the cervix

Lee

Flynn

2000

Cancer

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“…Many authors have already studied cytological and histological changes in the glandular and squamous epithelium of the uterine cervix in recent years [10][11][12][13]. An important step towards the evaluation of the findings of epithelium abnormalities was in 2001 the Bethesda system which supported the communication between gynecologists and cytopathologists [14,15].…”

Section: Discussionmentioning

confidence: 99%

Issues of the Evaluation of Endocervical Cells of the Uterine Cervix on Cytological Smears

Horáček¹

2015

CTB

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“…Mitoses are frequent. Mucin formation is absent or minimal (uniform type of Gloor and Ruzicka 1982;Figs. 141, 142).…”

Section: Adenocarcinoma In Situ [8140/2] (Figs 141-149)mentioning

confidence: 99%

Color Atlas of Histopathology of the Cervix Uteri

Dallenbach-Hellweg¹,

Doeberitz²,

Trunk³

2006

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The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in optimizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e.g., the overexpression of p16INK4a as a molecular marker in the early differential diagnosis of premalignant lesions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cellular and nuclear deregulation at the molecular level. All chapters have been revised to include the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic illustrations. The tumor nomenclature is adapted to the latest edition of the WHO classification; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications.Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly. Because of the lifestyles of the modern permissive society, cervical viral infections have become epidemic, resulting in inflammatory and precancerous lesions that were uncommon but now are seen mainly in the younger age groups with increasing frequency. Then too, progress in molecular biology and immunohistochemistry has enabled us to distinguish subtypes of papilloma viruses, to proceed in understanding their action within the genome, and to trace the infected metaplastic and neoplastic-transformed cells to their histogenetic origins. The resultant refined classification of cervical neoplasias has helped to predict clinical outcome and to choose type of therapy.This atlas is intended for all pathologists, to aid them in their routine diagnostic work. We hope it explains just how comprehensive, important and complex the histopathology of the cervix uteri has become during the last few years. It covers all pertinent differential diagnostic aspects and describes in detail how to reach the correct diagnosis. The atlas is also meant for the clinician, to guide him in his often difficult decision of how to provide optimal care for the frequently young patient, who desires children but is at risk for cancer. In particular, the atlas is designed to foster an improved dialogue between the pathologist and the clinician.The microphotographs were selected from our daily diagnostic material, since they show best the technical variations confronting the clinical pathologist in his daily routine, where effects of specimen transport, differences in ...

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Morphology of adenocarcinomain situ of the uterine cervix: A study of 14 cases

Cited by 55 publications

References 12 publications

Early invasive adenocarcinoma of the cervix

Early invasive adenocarcinoma of the cervix

Issues of the Evaluation of Endocervical Cells of the Uterine Cervix on Cytological Smears

Color Atlas of Histopathology of the Cervix Uteri

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