Morphology of changes in intestine and peritoneum walls after sanation of the abdominal cavity with sodium hypochlorite solution in rats with peritonitis

Abstract

The aim of the study was to reveal the effect of sodium hypochlorite (HCH) solution at concentrations of 0.022%, 0.045% and 0.09% on the morphology of the intestinal wall and peritoneum during peritonitis in the experiment. Materials and methods. The study was carried out on 72 infertile sexually mature rats of both sexes weighting 190-250 g. The animal under ether anesthesia was performed laparotomy and modeling peritonitis according to the method by M.A. Magomedov. On day 1, all rats were irrigated with sodium hypochlorite solution at different concentrations (5 min). Selection of the material for study (part of the intestine) was carried out on the 1, 3 and 7th day of the experiment. Results. Sodium hypochlorite (0.022% and 0.045%) have not a proper antiseptic effect on microorganisms in secondary peritonitis. The HCH solution (0.09%) produces a sufficient bacterial and detergent effect, but contributes to secondary damage to abdominal tissues. Conclusions. 1. As an antiseptic can be recommended 0.09% solution of sodium hypochlorite with an exposure of 3-5 minutes to prevent the development of peritonitis 2. The use of low concentrations of sodium hypochlorite is possible for the purpose of mechanical cleaning of the abdominal cavity.