Morphology of gastrointestinal effects of aspirin

Hahn, Klaus-Jürgen; Krischkofski, Dietmar; Weber, E.; Morgenstern, Eberhard

doi:10.1002/cpt1975173330

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…These results are in agree ment with previous studies reporting the defi ciency of mucin production and/or storage in gastric mucosa of animals or humans treated with aspirin and studied under fasting condi tions (3,9,12,14,33).…”

Section: Fasting Secretionsupporting

confidence: 93%

“…Histochemical studies of salicylateinduced lesions of gastric mucosa in rats (12) demonstrated a reduction in mucopolysaccha rides in both surface and deeply situated mucous-secreting cells. Aspirin-induced lesions of human and guinea pig gastric mucosa dis played various degrees of damage to the mu cous cells, consisting mostly of cytolysis and desquamation (33). Menguy and Masters (14) studied the effect of parenteral aspirin in rats and dogs and found inhibition of the rate of gastric mucus production; the reduction of hexosamine and A-fucose was observed in histochemically stained gastric mucosa sections.…”

Section: General Commentsmentioning

confidence: 99%

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Composition of Gastric Mucinous Secretion from Heidenhain Pouches of Dogs Treated with Aspirin

1979

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Principal glycoproteins and amino acids of secretions from Heidenhain pouches were studied in control and aspirin-treated dogs in the resting state of fasting and during stimulation with pentagastrin. All samples showed the presence of galactose, galactosamine, glucosamine, glucose, fucose, mannose, uronic acid and sulfate. Galactose and glucosamine were found in equimolar amounts, and the galactose/galactosamine ratio was 2/1. Pentagastrin induced the reduction in concentration of major carbohydrate components and amino acids of gastric mucus. The concentrations of major carbohydrate components and of amino acids of gastric secretions were lower in aspirin-treated animals than in controls.

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Section: Fasting Secretionsupporting

confidence: 93%

Section: General Commentsmentioning

confidence: 99%

Composition of Gastric Mucinous Secretion from Heidenhain Pouches of Dogs Treated with Aspirin

1979

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“…It will be of interest to correlate the functional changes of intestinal absorption noted in our study with possible structural alterations of intestinal epithelial cells. In one study, Hahn et al (1975) examined the effect of aspirin on the ultrastructure ofjejunal mucosa after administration of 3 g aspirin daily for three to five days. They found a marked increase of secondary lysosomes, probably representing autophagolysosomes, as well as an increase of multivesicular bodies.…”

Section: Discussionmentioning

confidence: 99%

Effect of aspirin on intestinal absorption of glucose, sodium, and water in man.

Arvanitakis¹,

Chen²,

Folscroft³

et al. 1977

Gut

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SUMMARY The effect of aspirin on small intestinal function in six healthy volunteers was examined using a segmental perfusion technique, with a test solution of 40 mM D-glucose, 140 mM NaCl, and 0*5 % polyethylene glycol. Jejunal glucose, sodium, and water absorption rates were inhibited by 50 % after oral administration of 2-6 g aspirin. Adenosine triphosphate (ATP) concentration was assayed in jejunal mucosal biopsies before and after aspirin. There was an almost 50 %g decrease in mucosal ATP levels after aspirin. This effect may be mediated through cellular injury and impairment of mitochondrial energy metabolism. Received for publication 6 October 1976 homeostasis is influenced by the rate of intestinal glucose absorption, it may be asked whether salicylates affect glucose levels by impairing glucose transport. Although the effect of aspirin on gastric mucosal structure and function has been studied extensively, there is very little information regarding the effect of aspirin on small intestinal function. Aspirin is absorbed from the stomach, as well as from the mucosa of the upper small intestine. The rate of absorption depends on the amount of nonionised drug and its lipid solubility. Because of the low intragastric pH, aspirin is absorbed rapidly from the gastric mucosa in the nonionised form. However, an appreciable amount is also absorbed from the jejunum, since the intraluminal pH in proximal jejunum may be as low as 5 0-5 5, and approximately 10% aspirin would be still in a nonionised form, suitable for absorption (Woodbury, 1970). The large jejunal absorptive surface and the intestinal blood flow are also important factors which would influence aspirin absorption rates. Contact of aspirin with the brush border may have an effect on intestinal transport of nutrients predominantly absorbed from the jejunum.The purpose of this study was to examine the effect of a therapeutic dose of aspirin on jejunal absorption of glucose, sodium, and water. In addition, the effect of aspirin on ATP levels in jejunal biopsies was determined, since glucose and sodium transport depend on high energy compounds such as ATP. 187 on 11 May 2018 by guest. Protected by copyright.

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“…Lysosomal inclusion bodies have been described in the apical cytoplasm of small intestinal epithelial cells in / 3 lipoprotein deficiency (6), coeliac disease (14), tropical sprue (12), infantile malnutrition (5), Crohn's disease (15), and after aspirin ingestion (9). It has been suggested that these inclusion bodies are autophagosomes, bacteria or dead epithelial cells ingested by their neighbours.…”

Section: Ae Acrodermatitis Enteropathicamentioning

confidence: 99%

The Effect of Zinc Therapy on Lysosomal Inclusion Bodies in Intestinal Epithelial Cells in Acrodermatitis Enteropathica

et al. 1983

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Morphology of gastrointestinal effects of aspirin

Cited by 11 publications

References 7 publications

Composition of Gastric Mucinous Secretion from Heidenhain Pouches of Dogs Treated with Aspirin

Composition of Gastric Mucinous Secretion from Heidenhain Pouches of Dogs Treated with Aspirin

Effect of aspirin on intestinal absorption of glucose, sodium, and water in man.

The Effect of Zinc Therapy on Lysosomal Inclusion Bodies in Intestinal Epithelial Cells in Acrodermatitis Enteropathica

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