2020
DOI: 10.32364/2587-6821-2020-4-6-329-333
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Morphology of pancreatic endocrine cells in rats with type 2 diabetes after the long-term treatment with sulphonylureas

Abstract: Aim: to study the morphology of pancreatic islet cells in rats aged more than 1 year with experimental type 2 diabetes (T2D) that receive sulphonylureas for a long time.Patients and Methods: albino laboratory rats aged more than 1 year (equal to 40 years in humans) were enrolled in this experimental study. Streptozotocin and nicotinamide were administered to induce T2D (streptozotocin-nicotinamide-induced diabetic rats). The animals were divided into four groups, i.e., healthy controls, T2D with no treatment, … Show more

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