Morphology of the blastocysts correlates with results of PGS

Zhylkova, Y.; Feskov, O.; Feskov, V.; Yegunkova, O.; Zozulina, O.

doi:10.1016/j.rbmo.2019.03.053

Cited by 2 publications

(2 citation statements)

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“…These results support the benefits of expanding embryo culture to the blastocyst stage in order to influence an increase in implantation and pregnancy rates. [11,12] Similar results were obtained from research conducted by Eftekhar et al (2020) showing blastocyst frozen embryo transfer had significantly increased pregnancy and implantation rates compared to cleavage embryo transfer [12] . Another study showed that day 3 frozen embryo transfer with high quality, determined using time-lapse monitoring, compared to blastocyst-stage embryos, assessed through conventional morphological selection, obtained the highest implantation rate in blastocyst-stage embryos.…”

Section: Discussionsupporting

confidence: 65%

Cleavage (Day 3) Vs Blastocyst (D5 and D6) Frozen Embryo Transfer

Parwati,

Karmaya,

2024

Int J Res Rev

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Objectives Knowledge about the success of the IVF program in frozen embryo transfer using cleavage stage (day 3) versus blastocyst stage (day 5 and day 6) is still limited. Several studies have found that embryo transfer at the blastocyst stage is more effective than at the cleavage stage. This study aimed to determine the quality of embryos after freezing-thawing and success rates on frozen embryo transfer on day 3 compared to day 5 and day 6. Materials and Methods: This retrospective case control analytic study included 157 participants aged below 40 years old who met our inclusion criteria between March 2018 to December 2022. Twenty-nine patients had day 3 frozen embryo transfers with a total of 65 frozen-thawed embryos, 110 patients had day 5 frozen embryo transfers with a total of 203 frozen-thawed blastocysts, and 18 patients had day 6 frozen embryo transfers with a total of 30 frozen-thawed blastocysts. Parameters were observed based on survival rate of embryos after freezing-thawing, number of embryo transfer per groups, pregnancy, implantation, miscarriages, intrauterine fetal death (IUFD), anembryonic pregnancy, and live birth rates. Results: There was no significant difference in survival rate of embryos after freezing-thawing among groups, however, pregnancy and implantation rates were significantly higher for day 5 frozen embryo transfer compared to those on day 3 and day 6 frozen embryo transfers. No significant differences were found in the miscarriage rate, IUFD, and live birth rate in the three groups. Keywords: day 3 frozen embryo transfer, day 5 and day 6 frozen embryo transfer, recovery embryos, pregnancy rate, implantation rate, live birth rate

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Section: Discussionsupporting

confidence: 65%

Cleavage (Day 3) Vs Blastocyst (D5 and D6) Frozen Embryo Transfer

Parwati,

Karmaya,

2024

Int J Res Rev

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“…Embryo quality has always been considered an important predictor of successful implantation 8 . Previous studies have highlighted that extended embryo culture until the blastocyst stage is the best way to select useful embryos for transfer or cryopreservation 9 , 10 , with higher likelihoods of implantation in comparison with early cleaved embryos 11 .…”

Section: Introductionmentioning

confidence: 99%

Extended embryo culture is effective for patients of an advanced maternal age

Sainte-Rose

Petit

Dijols

et al. 2021

Sci Rep

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The aim of this study was to determine the effectiveness of extended embryo culture in advanced maternal age (AMA) patients (37–43 years). In this retrospective analysis, 21,301 normally fertilized zygotes from 4952 couples were cultured until the blastocyst stage. Blastocyst development, including kinetics and morphology, transfer rate, implantation and live birth rates, were measured. In AMA patients, the blastocyst rate was significantly decreased as compared to that in younger women. On day 5, blastocysts underwent growth retardation in AMA patients, which was highlighted by a decreased rate of full/expanded blastocysts. Organization of the cells (trophectoderm and inner cell mass) was unaffected by age. However, in AMA patients, a ‘good’ morphology blastocyst had a decreased probability to implant compared with an ‘average’ morphology blastocyst in younger women. While the rates of blastocyst transfer and useful blastocysts were similar to younger patients, in AMA patients, both implantation and live birth rates were significantly reduced. Our results support the idea that extended embryo culture is not harmful for AMA patients. However, embryo selection allowed by such culture is not powerful enough to avoid chromosomal abnormalities in the developed blastocysts and therefore cannot compensate for the effect of a woman’s age.

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Morphology of the blastocysts correlates with results of PGS

Cited by 2 publications

References 0 publications

Cleavage (Day 3) Vs Blastocyst (D5 and D6) Frozen Embryo Transfer

Cleavage (Day 3) Vs Blastocyst (D5 and D6) Frozen Embryo Transfer

Extended embryo culture is effective for patients of an advanced maternal age

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