Morphology of the cervix in women treated with synthetic progestins

Aberrant glandular polypi of the uterine cervix associated with contraceptive pills: Pathology and pathogenesis

“…Very few studies of the human cervix have been made in patients receiving this therapy. Maqueo, Azuela, Calderon, and Goldzieher (1966) studied cervical biopsies from 147 patients undergoing treatment with these preparations. Although they describe hypersecretion and glandular hyperplasia, no mention is made of aberrant glandular changes.…”

Microglandular hyperplasia of the cervix: frequency in cone specimens, histological patterns, clinical aspects and immunohistochemical markers for differential diagnosis with adenocarcinoma

“…MGH was associated with patients under either endogenous or exogenous hormone effects in 51.42% of the studied cases. It is a known fact that cervix mucosa responds to estrogen hormones (8,10,18,20,22) with a proliferation of the endocervical columnar cells. The progestinic stimulation increases the consistency of the mucous, making it thick.…”

Unsatisfactory colposcopy and the response to orally administered oestrogen: a randomized double blind placebo controlled trial

“…The histological changes seen in these two situations are similar, namely an increase in the vascularity of thc cervix, an increase in the number and size of glands, with active secretion of mucus and stromal oedema. Maqueo et al (1966) suggested that the intensity of these changes was related to the level and duration of exposurc to progestational agents, although Mingeot & Fievcz (1974) concluded that it was not possible on the available evidcncc to determine whether the oestrogenic or progestogenic component or both were responsible for the observed cervical changes. What is beyond question, however, is that all of thcse changes will tend to promote an increase in cervical vol-…”