Morphology of the murine peritoneum after pneumoperitoneum vs laparotomy

Abstract

Morphologic peritoneal alterations after pneumoperitoneum differed from those after laparotomy and were influenced by the type of gas, amount of pressure, and duration of insufflation. These peritoneal changes after pneumoperitoneum may be associated with a specific intraperitoneal tumor spread after laparoscopic cancer surgery.

Evaluation of peritoneal tissue by means of differential scanning calorimetry (DSC)

“…Several studies based on an animal model have showed that the bulging up of mesothelial cells occurs almost immediately after the initiation of a pneumoperitoneum. Additionally the gas pressure, type of gas and duration of insufflations used during laparoscopic surgery evokes changes to the integrity of the peritoneal layer [39,40]. The study performed by Fu et al evaluated the peritoneal morphology of patients undergoing laparoscopic surgery.…”

Morphology of the rat peritoneum after carbon dioxide and helium pneumoperitoneum: a scanning electron microscopic study

“…To determine the role of mesothelial alteration in the pathogenesis of intraabdominal tumor growth, several recent studies have examined the influence of pneumoperitoneum on the morphology of the peritoneum [6,20,22]. In a scanning electron microscopic study, Volz et al [22] found that in mice, CO 2 pneumoperitoneum caused morphologic changes of the peritoneum such as bulging of mesothelial cells and exposure of the basal lamina, which are typical for an inflammatory reaction of the peritoneum.…”

Minimally invasive surgery for gastric cancer — toward a confluence of two major streams: a review

“…Although evaluation of overall cost benefits in laparoscopic colorectal surgery is still controversial [35,36], a major group of laparoscopic colorectal surgeons is oriented to more extensive procedures for more advanced cases. In gastric cancer, however, we must consider the biological behavior of the disease entity including a relatively high risk of peritoneal dissemination, which might be promoted by laparoscopic procedures [37,38]. Recently Hirabayashi et al demonstrated that cell adhesion molecules integrin and CD44 play an important role in the development of port-site metastasis after laparoscopic surgery and proposed preventive effects through modulation of these molecules [39].…”