Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome

Yan, Xiaoqin; Wang, Junming; Zhang, Hong; Zhou, Xiongwu; Chen, Zhiqi

doi:10.1167/iovs.63.1.1

Cited by 16 publications

(19 citation statements)

References 25 publications

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“…The main outflow pathway of aqueous humor is the conventional trabecular meshwork–Schlemm’s canal pathway [ 44 ]. Yan et al have reported that the trabecular meshwork edema might play a role in the elevation of IOP in PSS [ 27 ]. However, besides the trabecular meshwork–Schlemm’s canal pathway, iris crypt could also drain aqueous humor.…”

Section: Discussionmentioning

confidence: 99%

“…All of them received ophthalmic examinations, including slit lamp examination, gonioscopy, corneal endothelial microscope, fundus examination, RNFL thickness measurement by SS-OCT (VG200S; SVision Imaging, Henan, China), C/D ratio assessment with fundus photographs (AFC-210, Nidek Co., Ltd., Gamagori, Aichi, Japan) by two glaucoma specialists (WC and ZC), axial length (AL) measurement (IOL-Master 500, Carl Zeiss Meditec, Dublin, OH, USA), and IOP measurement (Goldmann tonometry, Keeler Ltd., Windsor, UK). The diagnostic criteria of PSS were: (1) unilateral and recurrent disease attack; (2) transient IOP elevation with blurred vision; (3) hoar and white suet-shaped KPs and/or mild inflammation in the anterior chamber; (4) open anterior chamber angle without iris synechiae [ 27 ]. Patients with a history of ocular surgery or systemic diseases were excluded from this study.…”

Section: Methodsmentioning

confidence: 99%

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Quantification of Iris Atrophy by Swept-Source Optical Coherence Tomography in Posner–Schlossman Syndrome

Yan

Chen

2022

JCM

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Purpose: To investigate iris atrophy in Posner–Schlossman syndrome (PSS). Methods: Sixty-one patients with PSS were included. Using swept-source optical coherence tomography, the thickness of anterior border layer (A), middle stromal layer (M), and the posterior pigmented epithelial layer (P) of iris were measured at 500 μm, 1000 μm, 1500 μm, 2000 μm, and 2500 μm from the pupillary edge in both PSS-affected and fellow eyes. The relationships between iris thickness and corneal endothelium density, cup-to-disc (C/D) ratio, and retinal nerve fiber layer (RNFL) thickness were also estimated in PSS-affected eyes. Results: Iris thickness parameters, including M500, M1000, A1500, A2000, P2000, and P2500, were significantly thinner in PSS-affected eyes than in fellow eyes (all p < 0.05). Moreover, M500 and M1000 were significantly associated with corneal endothelium density (p = 0.047 and 0.018, respectively), and M500 was significantly associated with C/D ratio (p = 0.001) and RNFL thickness (p = 0.037) in PSS-affected eyes. Conclusions: Iris showed significant thinning and atrophy in PSS-affected eyes, and iris stromal thickness close to the pupillary edge could be a novel clinical predictor of the changes in corneal endothelium, C/D ratio, and RNFL thickness in PSS.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Quantification of Iris Atrophy by Swept-Source Optical Coherence Tomography in Posner–Schlossman Syndrome

Yan

Chen

2022

JCM

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“…For quantification, high-power fields (×400 magnification) of the AHO from each model were captured. TM region was defined as the area between the ciliary body and the inner wall of Schlemm’s canal, with anterior and posterior end points of Schwalbe line and scleral spur, respectively ( Yan et al, 2022 ). For microfilament quantification, five fields with ×80,000 magnification of each group were captured with TEM, within which two were from the cell cortex region (defined as within 400 nm beneath the cell membrane) ( Svitkina, 2020 ) and the remaining three were beyond this area.…”

Section: Methodsmentioning

confidence: 99%

Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals

Zhang

Zhao

et al. 2023

eLife

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This study aimed to investigate the protective effect of metformin on trabecular meshwork (TM) and explore its molecular mechanisms in vivo and in vitro. Ocular hypertension (OHT) mouse models were induced with dexamethasone and further treated with metformin to determine the intraocular pressure (IOP)-lowering effect. Cultured human TM cells (HTMCs) were pre-stimulated with tert-butyl hydroperoxide (tBHP) to induce oxidative damage and then supplemented with metformin for another 24 hr. The expression of fibrotic markers and integrin/Rho-associated kinase (ROCK) signals, including α-smooth muscle actin (α-SMA), transforming growth factor-β (TGF-β), fibronectin, integrin beta 1, ROCK 1/2, AMP-activated protein kinase, myosin light chain 1, and F-actin were determined by western blotting and immunofluorescence. Reactive oxygen species (ROS) content was analysed using flow cytometry. Transmission electron microscopy was performed to observe microfilaments in HTMCs. It showed that metformin administration reduced the elevated IOP and alleviated the fibrotic activity of aqueous humour outflow in OHT models. Additionally, metformin rearranged the disordered cytoskeleton in the TM both in vivo and in vitro and significantly inhibited ROS production and activated integrin/ROCK signalling induced by tBHP in HTMCs. These results indicated that metformin reduced the elevated IOP in steroid-induced OHT mouse models and exerted its protective effects against oxidative injury by regulating cytoskeleton remodelling through the integrin/ROCK pathway. This study provides new insights into metformin use and preclinical evidence for the potential treatment of primary open-angle glaucoma.

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“…[3][4][5][6] Currently more attention has been paid to the effect of secondary glaucoma on the prognosis of PSS, and relatively little research has focused on CEC. 3,7,8 The endothelium is essential for maintaining corneal transparency and hydration. 9 The number of endothelial cells decreases gradually throughout life with limited regenerative potential.…”

Section: Introductionmentioning

confidence: 99%

“…3–6 Currently more attention has been paid to the effect of secondary glaucoma on the prognosis of PSS, and relatively little research has focused on CEC. 3,7,8…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with corneal endothelial cell density in Posner-Schlossman syndrome

Wang

Zeng

et al. 2022

European Journal of Ophthalmology

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Purpose To investigate the risk factors related to corneal endothelial cell density (ECD) in patients with Posner-Schlossman syndrome (PSS). Patients and methods It was an observational retrospective study. We reviewed the medical records of patients with PSS who attended the ophthalmology department at Wuhan University Zhongnan Hospital from January 2019 to December 2021. 42 eyes of 42 patients with PSS were included in the study. Demographic characteristics and clinical manifestations were recorded. The clinical characteristics of PSS patients with reduced ECD were compared with PSS patients with normal ECD. Simple and multiple linear regression analyses were carried out to identify the risk factors for ECD in PSS. Results The ECD-lowered group had a longer disease duration ( P = 0.000), higher rate of occurrence of corneal edema ( P = 0.039), higher cytomegalovirus (CMV) deoxyribonucleic acid (DNA) copy number ( P = 0.044), higher interleukin-10 (IL-10) level in the aqueous humor ( P = 0.044), and thinner average retinal nerve fiber layer (RNFL) thickness ( P = 0.016) than the control group. The results of multiple linear regression analysis indicated that disease duration (β = − 0.287, P = 0.024) and level of IL-10 in the aqueous humor (β = − 0.408, P = 0.001) were significantly negatively associated with ECD, while average RNFL thickness (β = 0.330, P = 0.007) was significantly positively related to ECD in PSS. Conclusion A longer disease duration, higher degree of glaucomatous damage and elevated level of IL-10 in the aqueous humor were associated with reduced ECD in PSS.

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Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome

Cited by 16 publications

References 25 publications

Quantification of Iris Atrophy by Swept-Source Optical Coherence Tomography in Posner–Schlossman Syndrome

Quantification of Iris Atrophy by Swept-Source Optical Coherence Tomography in Posner–Schlossman Syndrome

Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals

Risk factors associated with corneal endothelial cell density in Posner-Schlossman syndrome

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