Morphomechanics of tumors

Zhang, Huanxin; Li, Bo; Shao, Yue; Feng, Xi‐Qiao

doi:10.1016/j.cobme.2020.01.004

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…The relaxation of residual stresses can also drive tissue decompression (e.g. [10,[105][106][107][108][109]). Further studies are however required to understand and correctly capture postoperative brain biomechanical changes.…”

Section: Discussionmentioning

confidence: 99%

Modelling glioma progression, mass effect and intracranial pressure in patient anatomy

Lipková

Menze

Wiestler

et al. 2022

J. R. Soc. Interface.

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Increased intracranial pressure is the source of most critical symptoms in patients with glioma, and often the main cause of death. Clinical interventions could benefit from non-invasive estimates of the pressure distribution in the patient's parenchyma provided by computational models. However, existing glioma models do not simulate the pressure distribution and they rely on a large number of model parameters, which complicates their calibration from available patient data. Here we present a novel model for glioma growth, pressure distribution and corresponding brain deformation. The distinct feature of our approach is that the pressure is directly derived from tumour dynamics and patient-specific anatomy, providing non-invasive insights into the patient's state. The model predictions allow estimation of critical conditions such as intracranial hypertension, brain midline shift or neurological and cognitive impairments. A diffuse-domain formalism is employed to allow for efficient numerical implementation of the model in the patient-specific brain anatomy. The model is tested on synthetic and clinical cases. To facilitate clinical deployment, a high-performance computing implementation of the model has been publicly released.

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Section: Discussionmentioning

confidence: 99%

Modelling glioma progression, mass effect and intracranial pressure in patient anatomy

Lipková

Menze

Wiestler

et al. 2022

J. R. Soc. Interface.

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“…They respond to these forces by modifying their shape and by generating forces. In this regard, tumor cells behave abnormally because they have lost cell–cell adhesion and have growth defects ( Pham et al, 2010 ; Zhang et al, 2020 ) that give rise to abnormal shapes. Moreover, by remodeling the extracellular matrix, tumor cells can invade adjacent tissue ( Mierke, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Surface tension of model tissues during malignant transformation and epithelial–mesenchymal transition

Nagle

Richert

Quinteros

et al. 2022

Front. Cell Dev. Biol.

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Epithelial–mesenchymal transition is associated with migration, invasion, and metastasis. The translation at the tissue scale of these changes has not yet been enlightened while being essential in the understanding of tumor progression. Thus, biophysical tools dedicated to measurements on model tumor systems are needed to reveal the impact of epithelial–mesenchymal transition at the collective cell scale. Herein, using an original biophysical approach based on magnetic nanoparticle insertion inside cells, we formed and flattened multicellular aggregates to explore the consequences of the loss of the metastasis suppressor NME1 on the mechanical properties at the tissue scale. Multicellular spheroids behave as viscoelastic fluids, and their equilibrium shape is driven by surface tension as measured by their deformation upon magnetic field application. In a model of breast tumor cells genetically modified for NME1, we correlated tumor invasion, migration, and adhesion modifications with shape maintenance properties by measuring surface tension and exploring both invasive and migratory potential as well as adhesion characteristics.

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“…The brain cannot expand to make space for a growing mass; therefore, growing tumors compress normal tissue and can cause symptoms like seizures, stumbling, difficulty when walking, weakness on one side of the body, and vomiting. [ 28 ] More than 120 types of brain tumors have been reported. [ 29 ] These were traditionally classified based on their histological characteristics by the World Health Organization.…”

Section: Brain Cancers and Treatment Statusmentioning

confidence: 99%

Insights into Targeted and Stimulus‐Responsive Nanocarriers for Brain Cancer Treatment

Abousalman‐Rezvani,

Refaat,

Dehghankelishadi

et al. 2024

Adv Healthcare Materials

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Brain cancers, especially glioblastoma multiforme (GBM), are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology to treat various diseases, including cancers, and has played an indispensable role in combatting the COVID‐19 pandemic as evidenced by the role that lipid nanocarrier‐based vaccines have played. The tunability of nanocarrier physicochemical properties – including size, shape, surface chemistry, and drug release kinetics – has resulted in the development of a wide range of nanocarriers for brain cancer treatment. These nanocarriers can improve the pharmacokinetics of drugs, increase blood‐brain barrier (BBB) transfer efficiency, and specifically target brain cancer cells. These unique features would potentially allow for more efficient treatment of brain cancer with less side effects and better therapeutic outcomes. This review provides an overview of brain cancers, current therapeutic options, and challenges to efficient brain cancer treatment. The latest advances in nanomedicine strategies are investigated with an emphasis on targeted and stimulus‐responsive nanocarriers and their potential for clinical translation.This article is protected by copyright. All rights reserved

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Morphomechanics of tumors

Cited by 8 publications

References 48 publications

Modelling glioma progression, mass effect and intracranial pressure in patient anatomy

Modelling glioma progression, mass effect and intracranial pressure in patient anatomy

Surface tension of model tissues during malignant transformation and epithelial–mesenchymal transition

Insights into Targeted and Stimulus‐Responsive Nanocarriers for Brain Cancer Treatment

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