Morphometric Alterations Induced by the Toxicity of Variable Sizes of Silver Nanoparticles

Al‐Μansour, Mubarak; Jarrar, Qais; Battah, Abdelkader; Jarrar, Bashir M.

doi:10.4067/s0717-95022015000200022

Cited by 12 publications

(13 citation statements)

References 22 publications

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“…Our results reveal that 10 nm Ag NPs are toxic and can induce microanatomical, histochemical and ultrastructural hepatic alterations. These findings are online with some previous studies [44,[48][49][50][51]. In addition, several researchers reported that smaller NPs have great ratio of surface area to volume and have long circulating residue with potential toxicity that could be related to reactive surface area bioavailability and dissolution rate [25].…”

Section: Discussionsupporting

confidence: 90%

Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles

Al‐Doaiss

Jarrar

Moshawih³

2020

IET nanobiotechnol.

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Silver nanoparticles (Ag NPs) are invested in various sectors and are becoming more persistent in our ambient environment with potential risk on our health and the ecosystems. The current study aims to investigate the histological, histochemical and ultrastructural hepatic changes that might be induced by 10 nm silver nanomaterials. Male mice (BALB/C) were exposed for 35 injections of daily dose of 10 nm Ag NPs (2 mg/kg). Liver tissues were subjected to examination by light and electron microscopy for histological, histochemical and ultrastructural alterations. Exposure to Ag NPs induced Kupffer cells hyperplasia, sinusoidal dilatation, apoptosis, ground glass hepatocytes appearance, nuclear changes, inflammatory cells infiltration, hepatocytes degeneration and necrosis. In addition, 10 nm Ag NPs induced histochemical alterations mainly glycogen depletion with no hemosiderin precipitation. Moreover, these nanomaterials exhibited ultrastructure alterations including mitochondrial swelling and cristolysis, cytoplasmic vacuolation, apoptosis, multilammellar myelin figures formation and endoplasmic destruction and reduction. The findings revealed that Ag NPs can induce alterations in the hepatic tissues, the chemical components of the hepatocytes and in the ultrastructure of the liver. One may also conclude that small size Ag NPs, which are increasingly used in human products could cause various toxigenic responses to all hepatic tissue components.

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Section: Discussionsupporting

confidence: 90%

Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles

Al‐Doaiss

Jarrar

Moshawih³

2020

IET nanobiotechnol.

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“…They concluded that a high dose of SNPs reduces the antioxidant capacity due to oxidative stress (Ranjbar et al., 2014). As other researchers have indicated (Almansour et al., 2017; Ranjbar et al., 2014), the results of this study showed that SNPs increased MDA level (well‐known LPO indicator) and a significant decrease in TAC levels in the group treated with SNPs compared to the control group. Therefore, SNPs induce ROS production and cause DNA damage, protein carbonisation and membrane oxidation by inhabiting reduced glutathione (GSH) (Ahmed et al., 2017).…”

Section: Discussionsupporting

confidence: 78%

“…On the other hand, SNPs increase the free oxygen, such as super oxidase, and also increase the oxidation of molecules including proteins which ultimately reduces the number of Leydig cells and decreases the production of testosterone. As other researchers found (Almansour et al., 2017; Rezaei‐Zarchi et al., 2013), there is a significant decrease in serum testosterone levels in the group treated with SNPs in comparison with the control group. This can be occurred due to the destruction of Leydig cells and abnormalities in the function and number of Sertoli cells and consequently disequilibrium of sex hormones.…”

Section: Discussionsupporting

confidence: 67%

“…Almansour et al studied the effect of SNPs on a dose of 1mg/kg and a size of 10–20–40 –60–100 nm for 35 days. It was shown that smaller nanoparticles have more destructive effects on cells such as Leydig cells due to the easier passage through the blood‐testis barrier and they reduce testosterone levels (Almansour et al., 2017). Rezaei‐Zarchi et al., (2013) studying SNPs concluded that they could affect the mitochondrial activity of Leydig cells and, so they reduce its secretory activity.…”

Section: Discussionmentioning

confidence: 99%

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The protective effect of Kombucha against silver nanoparticles‐induced toxicity on testicular tissue in NMRI mice

2021

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Silver nanoparticles (SNPs) can pass from the cell membrane and testicular blood barrier due to their small size, and by increasing oxidative stress they cause disorder in the male reproductive system. Kombucha is a traditional fermented drink with detoxification and potent antioxidant properties. We aimed to examine the protective effect of Kombucha against the damages due to SNPs on the testis tissue. In this experimental study, NMRI mice were randomly separated into four groups (n = 6), namely control (distilled water), SNPs (500 mg/kg), Kombucha extract (9 ml/kg) and SNPs + Kombucha, and were treated with gavage for 35 days. A significant decrease in testosterone level and total antioxidant capacity, and a significant increase in malondialdehyde concentration was observed in the SNPs group in comparison with the control group. Histological studies on the testis of mice treated with SNPs showed vacuolation, decrease in generational epithelium thickness, seminiferous tubules diameter, testis volume and the number of spermatozoa in lumen of the seminiferous tubule and increase in the volume of interstitial space while the mentioned parameters were improved in the SNPs + Kombucha group compared to the SNPs group. Kombucha reduces the adverse effects of SNPs on testis tissue and improves the function of the male reproductive system.

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“…It is suspected that this could occur because the roselle leaf extract with various doses might be able to have a positive impact on reducing the liver weight of mice in treatment. According to Almansour [15], the liver weight of normal adult mice ranges from 1.2-1.6 g. The decreasing of the liver weight in P1, P2 and P3 was seen to be closer to the normal liver weight of mice. Thus, it seems that giving roselle leaf extract can improve the reduction in liver weight of mice.…”

Section: Liver Weight Of Micementioning

confidence: 82%

Potency of Rosela Leaves (Hibiscus sabdariffa L.) as a Hepatoprotector to Histological Structure Damage of the Hepar of Mice Male (Mus musculus L.) Strain DDW that Proposed Natrium Nitrite (NaNO2)

Sabri¹

2020

Int J Ecophysiol

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The study of Rosela Leaf Extract As A Protective Agent Against The Damage Of Liver Tissue OfMale Mice Strain DDW that has been Induced By Sodium Nitrite was conducted. The experiment used Completely Randomized Design. The treatment given was three different dosages of rosella leaf extract, namely 14 mg / ml, 28 mg / ml and 42 mg / ml and without any extract as a control. All mice have been induced by sodium nitrite for 18 days followed by healing process through injection of 0.3 ml of rosella leaf extract at different concentration per day during 14 days. The result showed that he control, treatment of 14 mg / ml and 42 mg / ml affected the color change of liver tissue. However, the control increased liver tissue weight compared to all treatments. The damage levels of hepatocyte tissue treated by all different dosages of fresh rosella leaf extract decreased compared to the damage level of control. It could be concluded that fresh rosella leaf extract showed potential agent to protect liver mice from damage caused by sodium nitrite induction.

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Morphometric Alterations Induced by the Toxicity of Variable Sizes of Silver Nanoparticles

Cited by 12 publications

References 22 publications

Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles

Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles

The protective effect of Kombucha against silver nanoparticles‐induced toxicity on testicular tissue in NMRI mice

Potency of Rosela Leaves (Hibiscus sabdariffa L.) as a Hepatoprotector to Histological Structure Damage of the Hepar of Mice Male (Mus musculus L.) Strain DDW that Proposed Natrium Nitrite (NaNO2)

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