Morphometric and biomechanical remodeling of the small intestine during aging in rats

Zhao, Jingbo; Gregersen, Hans

doi:10.1016/j.jbiomech.2015.10.034

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…Rather, other factors such as changes in the remaining tissue structure and composition may play a role. This is supported by a previous study demonstrating that wall stiffness is also a determining factor …”

Section: Discussionsupporting

confidence: 86%

Low‐residue diet fed to rabbits induces histomorphological and biomechanical remodeling of small intestine

Liu

Zhao

Liao

et al. 2016

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 86%

Low‐residue diet fed to rabbits induces histomorphological and biomechanical remodeling of small intestine

Liu

Zhao

Liao

et al. 2016

Neurogastroenterology Motil

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“…In other types of cells, aging is associated with a decrease in cellular function that results in less effective cytoskeletal remodeling and slower motion 41 . Extrinsic factors, such as increased tissue stiffness with aging, could in part underlie this alteration in cell contractility and motion [42][43][44] . Here, we found that the motion of neighboring cells was dramatically impaired, and cell debris 'lingered' in the crypts of old animals.…”

Section: Discussionmentioning

confidence: 99%

Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Choi

Rakhilin

Gadamsetty

et al. 2017

Preprint

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Despite the continuous renewal and turnover of the small intestinal epithelium, the intestinal stem cell niche maintains a 'soccer ball-like', alternating pattern of stem and Paneth cells in the crypt. To study the robustness of the niche pattern, we used intravital two-photon microscopy in mice with fluorescently-labeled Lgr5+ intestinal stem cells and precisely perturbed the mosaic pattern with femtosecond laser ablation. Ablation of one to three cells initiated rapid motion of niche cells that restored the alternation in the crypt pattern within about two hours without any cell proliferation. Crypt cells then performed a coordinated dilation of the crypt lumen, which resulted in peristalsis-like motion that forced damaged cells out of the niche. Crypt cell motion was reduced with inhibition of the ROCK pathway and attenuated with old age, and both resulted in incomplete pattern recovery. This suggests that in addition to proliferation and self-renewal, motility of stem cells is critical for maintaining homeostasis. Reduction of this novel behavior of stem cells could contribute to disease and age-related changes.

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“…The effect of partial obstruction on the active behaviour of the small intestine was studied in guinea pigs (Zhao et al. 2011a , b ), while Zhao and Gregersen ( 2015 ) studied the effect of ageing on the passive material response of the organ in rats.…”

Section: Review Findingsmentioning

confidence: 99%

“…( 2012 ); Zhao et al. ( 2013b , a ); Zhao and Gregersen ( 2015 ); Sun et al. ( 2017 ); Sokolis ( 2017 ); Zhao et al.…”

Section: Review Findingsmentioning

confidence: 99%

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Mechanical experimentation of the gastrointestinal tract: a systematic review

Durcan,

Hossain,

Chagnon

et al. 2023

Biomech Model Mechanobiol

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The gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medicine and engineering. This systematic review summarises the experimental studies that are currently in the literature (n = 247) and outlines the areas in which experimentation is lacking, highlighting what is still required in order to more fully understand the mechanical behaviour of the GI organs. These include (i) more human data, allowing for more accurate modelling for applications within medicine, (ii) an increase in time-dependent studies, and (iii) more sophisticated in vivo testing methods which allow for both the layer- and direction-dependent characterisation of the GI organs. The findings of this review can also be used to identify experimental data for the readers’ own constitutive or FE modelling as the experimental studies have been grouped in terms of organ (oesophagus, stomach, small intestine, large intestine or rectum), test condition (ex vivo or in vivo), number of directions studied (isotropic or anisotropic), species family (human, porcine, feline etc.), tissue condition (intact wall or layer-dependent) and the type of test performed (biaxial tension, inflation–extension, distension (pressure-diameter), etc.). Furthermore, the studies that investigated the time-dependent (viscoelastic) behaviour of the tissues have been presented.

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Morphometric and biomechanical remodeling of the small intestine during aging in rats

Cited by 8 publications

References 38 publications

Low‐residue diet fed to rabbits induces histomorphological and biomechanical remodeling of small intestine

Low‐residue diet fed to rabbits induces histomorphological and biomechanical remodeling of small intestine

Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Mechanical experimentation of the gastrointestinal tract: a systematic review

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