Morphometric and immunohistochemical features of the gastric and duodenal mucosa in systemic lupus erythematosus

Musaev, S N; Novikova, A. V.; Shershevskaya, A. Ya; Klimanskaya, E. V.; Aksenova, I. V.

doi:10.1007/bf00842696

Cited by 10 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, SLE flare with vasculitis was the most reasonable explanation for a gastric ulcer in our patient [ 1 , 5 ]. Musaev et al revealed that SLE itself may cause gastritis [ 10 ], showing support that gastric ulcers may be primarily autoimmune in this SLE patient.…”

Section: Discussionmentioning

confidence: 64%

A Rare Case of Systemic Lupus Erythematosus with Gastric Ulcer and Acute Pancreatitis: A Case Report and Literature Review

et al. 2018

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease which can manifest in many different organ systems. Gastrointestinal (GI) involvement is common in SLE, but the symptoms are usually mild. More severe GI complications including acute pancreatitis and peptic ulcer bleeding are rare but represent a significant risk of morbidity and mortality. We present a case of a 25-year-old Hispanic female with a severe SLE flare. The initial presentation included symptoms of hematemesis and epigastric abdominal pain secondary to both gastric ulceration and acute pancreatitis, an atypical presentation of an SLE flare. The non-specific symptom of abdominal pain makes both acute pancreatitis and gastric ulcer disease a clinical challenge; however, clinicians need to have a high suspicion for these conditions co-existing at the same time due to higher mortality rates.

show abstract

Section: Discussionmentioning

confidence: 64%

A Rare Case of Systemic Lupus Erythematosus with Gastric Ulcer and Acute Pancreatitis: A Case Report and Literature Review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…As mentioned above, it is uncertain how, if at all, SLE by itself plays a role in gastritis and PUD. A Russian study compared gastric biopsies in 27 children with SLE against 12 with chronic gastroduodenitis and found the children with SLE had more inflammatory changes in the mucosa, including higher levels of fibroblasts and small vessel IgG immune complex deposition during periods of disease flare [30]. While the significance of these findings does not quantify the degree of association with ulcer disease, it does suppose that some risk for gastric lining compromise extends from SLE beyond the use of high risk medications.…”

Section: Stomachmentioning

confidence: 82%

The Gastrointestinal Manifestations of Systemic Lupus Erythematosus: A Survey of the Literature

Schulz¹,

Derk²

2009

TOAUTOJ

View full text Add to dashboard Cite

Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with auto-antibody production and resulting widespread inflammation that has potential to affect and damage many organ systems. Gastrointestinal manifestations of SLE are well documented in the literature but the exact extent and frequency of their presence is likely grossly underestimated. Patients present with vague complaints such as abdominal pain and nausea with non-specific physical exam findings and inconclusive diagnostic tests and serologic analysis. Recent research has helped to better clarify these manifestations of SLE and has demonstrated distinct involvement of almost every portion of the GI tract. This article is based upon an exhaustive review of the literature from 1976 to present date and summarizes the major advances in the identification and differentiation of gastrointestinal incarnations related to systemic lupus erythematosus. The review also encompasses theories of etiology of the various manifestations, summarizes accepted and experimental treatment regimens, and highlights the differential diagnosis of each presented topic, including disorders of the oropharynx, esophagus, stomach, small and large intestine, liver and gallbladder and beyond.

show abstract

“…Systemic complement activation can lead to diffuse microvascular injury and increase vascular permeability which may be present in the mesenteric circulation leading to intestinal capillary leak resulting in submucosal edema [ 13 ]. Similarly, Musaev et al [ 14 ] reported on 12 children with SLE and chronic gastroduodenitis. Biopsies of the stomach and duodenum during disease exacerbation revealed immune complex deposition in the arteriolar walls [ 14 ].…”

Section: Discussionmentioning

confidence: 97%

“…Similarly, Musaev et al [ 14 ] reported on 12 children with SLE and chronic gastroduodenitis. Biopsies of the stomach and duodenum during disease exacerbation revealed immune complex deposition in the arteriolar walls [ 14 ]. The same pathophysiology may be present in lupus enteritis.…”

Section: Discussionmentioning

confidence: 97%

Lupus Gastrointestinal Tract Vasculopathy: Lupus “Enteritis” Involving the Entire Gastrointestinal Tract from Esophagus to Rectum

Bert¹,

Gertner²

2017

Case Rep Gastroenterol

View full text Add to dashboard Cite

Gastrointestinal symptoms are very common in systemic lupus erythematosus (SLE). Lupus “enteritis” is very responsive to treatment but can have devastating consequences if not detected. Most descriptions of enteritis involve the small and large bowel. This is the first report of lupus “enteritis” involving the entire gastrointestinal tract from the esophagus and stomach to the rectum. Lupus “enteritis” is another cause of upper gastrointestinal involvement in SLE (involving even the esophagus and stomach) in addition to involvement of the lower intestinal tract.

show abstract

Morphometric and immunohistochemical features of the gastric and duodenal mucosa in systemic lupus erythematosus

Cited by 10 publications

References 1 publication

A Rare Case of Systemic Lupus Erythematosus with Gastric Ulcer and Acute Pancreatitis: A Case Report and Literature Review

A Rare Case of Systemic Lupus Erythematosus with Gastric Ulcer and Acute Pancreatitis: A Case Report and Literature Review

The Gastrointestinal Manifestations of Systemic Lupus Erythematosus: A Survey of the Literature

Lupus Gastrointestinal Tract Vasculopathy: Lupus “Enteritis” Involving the Entire Gastrointestinal Tract from Esophagus to Rectum

Contact Info

Product

Resources

About