Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography

Brais-Brunet, Simon; Heckel, Émilie; Kanniyappan, Udayakumar; Chemtob, Sylvain; Boudoux, Caroline; Joyal, Jean‐Sébastien; Dehaes, Mathieu

doi:10.1167/iovs.62.13.20

Cited by 3 publications

(2 citation statements)

References 89 publications

(157 reference statements)

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“…The finding that RNFL-GCL between 3–5 weeks of age tends to become thinner in all the groups of animals considered in the study ( Figure 2B ) is for sure intriguing but, at the very end, not so surprising. A previous study ( Brais-Brunet et al, 2021 ) in control mice shows that, when measured consecutively by OCT between postnatal days 7 and 21, the thicknesses of four retinal layers (RNFL, IPL, INL and ORL) are progressively and significantly changing, suggesting a temporal “plasticity” of the neural retina. Unfortunately, the above-described study was stopped at 21 days of age and cannot therefore be of use to quantify the change of RNFL thickness during the period of interest (3–5 weeks of age).…”

Section: Discussionmentioning

confidence: 89%

Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy

et al. 2022

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Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR is preceded and possibly caused by the neurodegeneration of retinal ganglion cells suggests that DR could, at least theoretically, be prevented through an early neuroprotective approach. The aims of our study were to clarify the natural history of diabetes-driven retinal neurodegeneration and to verify the possibility to prevent DR using topical nerve growth factor (NGF). The results of the study show that retinal neurodegeneration, characterized by the loss of retinal ganglion cells represents a relatively early phenomenon of diabetes (between 5 and 16 weeks of age), which tends to be self-limiting in the long run. Neurodegeneration is followed by the development of DR-related vascular dysfunctions, as confirmed by the development of acellular capillaries and the loss of retinal pericytes. Both retinal neurodegeneration and subsequent vascular dysfunction can be successfully prevented by topical NGF administration. These findings suggest that: 1) The first stage of DR consists in a self-limiting retinal neurodegeneration 2) The demonstrated effectiveness of topical NGF in the prevention of DR could be rapidly translated into clinical practice.

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Section: Discussionmentioning

confidence: 89%

Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy

et al. 2022

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“…Optical coherence tomography (OCT) makes it possible to deliver a considerable amount of morphological information through high-resolution raster scanning [ 7 ]. Central subfield thickness (CST) is commonly used as an OCT parameter to evaluate the severity of DME and its prognosis.…”

Section: Introductionmentioning

confidence: 99%

Artificial Intelligence-Based Quantification of Central Macular Fluid Volume and VA Prediction for Diabetic Macular Edema Using OCT Images

Ye,

Gao,

et al. 2023

Ophthalmol Ther

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Introduction We studied the correlation of central macular fluid volume (CMFV) and central subfield thickness (CST) with best-corrected visual acuity (BCVA) in treatment-naïve eyes with diabetic macular edema (DME) 1 month after anti-vascular endothelial growth factor (VEGF) therapy. Methods This retrospective cohort study investigated eyes that received anti-VEGF therapy. All participants underwent comprehensive examinations and optical coherence tomography (OCT) volume scans at baseline (M0) and 1 month after the first treatment (M1). Two deep learning models were separately developed to automatically measure the CMFV and the CST. Correlations were analyzed between the CMFV and the logMAR BCVA at M0 and logMAR BCVA at M1. The area under the receiver operating characteristic curve (AUROC) of CMFV and CST for predicting eyes with BCVA 20/40 at M1 was analyzed. Results This study included 156 DME eyes from 89 patients. The median CMFV decreased from 0.272 (0.061–0.568) at M0 to 0.096 (0.018–0.307) mm 3 at M1. The CST decreased from 414 (293–575) to 322 (252–430) μm. The logMAR BCVA decreased from 0.523 (0.301–0.817) to 0.398 (0.222–0.699). Multivariate analysis demonstrated that the CMFV was the only significant factor for logMAR BCVA at both M0 ( β = 0.199, p = 0.047) and M1 ( β = 0.279, p = 0.004). The AUROC of CMFV for predicting eyes with BCVA 20/40 at M1 was 0.72, and the AUROC of CST was 0.69. Conclusions Anti-VEGF therapy is an effective treatment for DME. Automated measured CMFV is a more accurate prognostic factor than CST for the initial anti-VEGF treatment outcome of DME. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-023-00746-5.

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MCOCT: an experimentally and numerically validated, open-source Monte Carlo simulator for optical coherence tomography

Erdenedalai,

Maltais-Tariant,

Dehaes

et al. 2024

Biomed. Opt. Express

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Here, we present MCOCT, a Monte Carlo simulator for optical coherence tomography (OCT), incorporating a Gaussian illumination scheme and bias to increase backscattered event collection. MCOCT optical fluence was numerically compared and validated to an established simulator (MCX) and showed concordance at the focus while diverging slightly with distance to it. MCOCT OCT signals were experimentally compared and validated to OCT signals acquired in tissue-mimicking phantoms with known optical properties and showed a similar attenuation pattern with increasing depth while diverging beyond 1.5 mm and proximal to layer interfaces. MCOCT may help in the design of OCT systems for a wide range of applications.

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Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography

Cited by 3 publications

References 89 publications

Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy

Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy

Artificial Intelligence-Based Quantification of Central Macular Fluid Volume and VA Prediction for Diabetic Macular Edema Using OCT Images

MCOCT: an experimentally and numerically validated, open-source Monte Carlo simulator for optical coherence tomography

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