Morphometric assessment of microvessel density in head and neck squamous cell carcinoma using immunomarker CD105 and its correlation with clinicopathological parameters

Marwah, Nisha; Parmar, Padam; Parshad, Sanjeev; Yadav, Taruna; Gupta, Sumiti; Sen, Rajeev

doi:10.4103/2278-0513.183546

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…After the duplicates were removed and exclusion of 2255 records due to coherence with the inclusion/exclusion criteria, 208 articles relevant to the topic were accurately evaluated. Two records were unavailable for retrieval; thus, 206 articles were assessed for eligibility, and 84 were included in the review [ 19 , 26 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ,...…”

Section: Resultsmentioning

confidence: 99%

“…All the 84 studies included in the qualitative analysis were ex vivo tissue investigations based on histopathological analysis of tumor biopsies or surgical specimens [ 19 , 26 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ,...…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

Alessandrini

Astolfi

Daloiso

et al. 2023

IJMS

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Despite refinements to diagnostic and therapeutic approaches over the last two decades, the outcome of patients with head and neck squamous cell carcinoma (HNSCC) has not shown substantial improvements, especially regarding those with advanced-stage disease. Angiogenesis is believed to be a turning point in the development of solid tumors, being a premise for mass growth and potential distant dissemination. Cancer-induced angiogenesis is a result of increased expression of angiogenic factors, decreased expression of anti-angiogenic factors, or a combination of both. The assessment of angiogenesis has also emerged as a potentially useful biological prognostic and predictive factor in HNSCC. The aim of this review is to assess the level of current knowledge on the neo-angiogenesis markers involved in the biology, behavior, and prognosis of HNSCC. A search (between 1 January 2012 and 10 October 2022) was run in PubMed, Scopus, and Web of Science electronic databases. After full-text screening and application of inclusion/exclusion criteria, 84 articles are included. The current knowledge and debate on angiogenesis in HNSCC presented in the eligible articles are stratified as follows: (i) diagnostic markers; (ii) prognostic markers; (iii) predictive markers; and (iv) markers with a potential therapeutic role. Angiogenesis is a biological and pathological indicator of malignancies progression and has negative implications in prognosis of some solid tumors; several signals capable of tripping the “angiogenic switch” have also been identified in HNSCC. Although several studies suggested that antiangiogenic agents might be a valuable adjunct to conventional chemo-radiation of HNSCC, their long-term therapeutic value remains uncertain. Further investigations are required on combinations of antiangiogenic agents with conventional chemotherapeutic ones, immunotherapeutic and molecularly targeted agents in HNSCC. Additional data are necessary to pinpoint which patients could benefit most from these treatments.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

Alessandrini

Astolfi

Daloiso

et al. 2023

IJMS

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An Immunohistochemical Study of E-Cadherin, Vimentin and Ki-67 Expression in Respect to Clinicopathological Profile of Oral Squamous Cell Carcinoma in a Tertiary Care Centre

Iqbal¹,

Pathuri²,

Padmaja³

2022

IJAR

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INTRODUCTION:- According to WHO, Oral cancer is one of the three most prevalent cancers in Asia, among which India accounts for approximately one third. Immunological markers E-cadherin, Vimentin and Ki-67 plays a major role in determining invasiveness, metastasis and prognosis of Oral Squamous Cell Carcinoma. To study the expression of immunological AIM:- markers E-cadherin, Vimentin and Ki-67 in Oral Squamous Cell Carcinoma and evaluate their expression concerning clinicopathological prole. METHODS:-It is a hospital-based cross-sectional study of 60 cases of Oral Squamous Cell Carcinoma done for two years. Expression of immunological markers E-cadherin, Vimentin and Ki-67 were evaluated and correlated with its pathology. Majority of the patients RESULTS:- with Oral Carcinoma belonged to the 51 – 60 years age group with male predominance(2.3:1). 45% had on Tongue, 22% on the buccal mucosa, 12% on Hard palate, 8% on Lips, 5% on Soft palate and Uvula,3% on Anterior pillar and Retromolar trigone and 2% on Floor of mouth. Ecadherin was positive in 72% with 38% strong positivity. Vimentin was positive in 33% with 20% strong positivity. Ki-67 expression was high in 67% of the cases. Lymph node metastasis showing 13% E-cadherin positivity , 22% Vimentin positive, 30% Ki-67 positive. CONCLUSION:- OSCC cell proliferation research must be further extended as it can be helpful to forecast survival rates for a deeper understanding of protein expression and the interaction between biomarker and therapeutic aspects of these patients.

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Morphometric assessment of microvessel density in head and neck squamous cell carcinoma using immunomarker CD105 and its correlation with clinicopathological parameters

Cited by 2 publications

References 2 publications

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

An Immunohistochemical Study of E-Cadherin, Vimentin and Ki-67 Expression in Respect to Clinicopathological Profile of Oral Squamous Cell Carcinoma in a Tertiary Care Centre

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