Morphometric characterisation of pterygium associated with corneal stromal scarring using high-resolution anterior segment optical coherence tomography

Gasser, Thomas; Romano, Vito; Seifarth, Christof; Bechrakis, Nikolaos E.; Kaye, Stephen B.; Steger, Bernhard

doi:10.1136/bjophthalmol-2016-308685

Cited by 32 publications

(27 citation statements)

References 13 publications

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“…These findings could be explained by the diversity of pterygium characteristics in our study, considering a large number of eyes with pterygium were included. Various characteristics of pterygium might have diverse effects on corneal astigmatism and subepithelial irregularities 18…”

Section: Discussionmentioning

confidence: 99%

Pattern of corneal astigmatism induced by primary pterygium in patients with cataract in a secondary hospital in Southern China: a cross-sectional study

Qi²,

2020

BMJ Open

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ObjectivesTo review the pattern of primary pterygium-induced corneal astigmatism in patients with cataract in a southern Chinese population.DesignClinic-based cross-sectional retrospective study.SettingA secondary hospital at southern China.ParticipantsA group of 1689 eyes with primary pterygium (PT group) and the other group of 4062 eyes without pterygium (NPT group) were included.Main outcome measuresCorneal power was measured by an autokeratorefractometer. Corneal astigmatism was calculated as the difference in corneal power between the steepest and flattest meridians. Distribution of corneal astigmatism was compared between eyes with pterygium and eyes without pterygium.ResultsDistribution of corneal astigmatism was different between PT group (skewness=2.548, kurtosis=8.237) and NPT group (skewness=2.778, kurtosis=15.52). Mean corneal astigmatism was significantly higher in the PT group (1.62±1.49D) compared with the NPT group (1.17±0.89D, p<0.0001). The prevalence of corneal astigmatism >1D (PT 52.3%, NPT 40.9%, p<0.0001), >2D (PT 22.4%, NPT 10.6%, p<0.0001) or >3D (PT 10.5%, NPT 3.2%, p<0.0001) was significantly higher in the PT group compared with the NPT group. Eyes in the PT group had significantly higher corneal astigmatism than the NPT group in almost every age group (all p<0.05), with the exception of patients ≥90 years. Moreover, eyes in the PT group had significantly higher with-the-rule (PT 1.72±1.59D, NPT 1.19±0.88D, p<0.0001) and against-the-rule (PT 1.63±1.46D, NPT 1.18±0.88D, p<0.0001) but similar oblique astigmatism (PT 1.11±1.00D, NPT 0.99±0.89D, p=0.065) corneal astigmatism compared with the NPT group. Power vector analysis indicated that the axis of corneal astigmatism was not significantly different between the two groups (J0, PT −0.01±0.74D, NPT 0.01±0.52D, p=0.48; J45, PT −0.03±0.82D, NPT 0.00±0.52D, p=0.54).ConclusionsPattern of corneal astigmatism in eyes with cataract and coexisting primary pterygium was different from eyes without pterygium. Pterygium is associated with higher magnitude but not different axis of corneal astigmatism.

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Section: Discussionmentioning

confidence: 99%

Pattern of corneal astigmatism induced by primary pterygium in patients with cataract in a secondary hospital in Southern China: a cross-sectional study

Qi²,

2020

BMJ Open

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“…Applications of AS-OCT in corneal disease are wide and clinically well established. This includes evaluation of pterygium [102], management guidance in ocular surface neoplasia [103], characterization of abnormalities associated with keratoconus [104-108], and evaluation of corneal wound healing [109-113]. The role of AS-OCT is also important in preoperative, intraoperative, and postoperative assessment of patients requiring corneal surgeries [111, 114-118].…”

Section: Imaging and Ne(ur)ovascularizationmentioning

confidence: 99%

New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting

et al. 2020

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To discuss and evaluate new technologies for a better diagnosis of corneal diseases and limbal stem cell deficiency, the outcomes of a consensus process within the European Vision Institute (and of a workshop at the University of Cologne) are outlined. Various technologies are presented and analyzed for their potential clinical use also in defining new end points in clinical trials. The disease areas which are discussed comprise dry eye and ocular surface inflammation, imaging, and corneal neovascularization and corneal grafting/stem cell and cell transplantation. The unmet needs in the abovementioned disease areas are discussed, and realistically achievable new technologies for better diagnosis and use in clinical trials are outlined. To sum up, it can be said that there are several new technologies that can improve current diagnostics in the field of ophthalmology in the near future and will have impact on clinical trial end point design.

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“…As such, it is most commonly seen in populations working outdoors or living in tropical climates. Studies have shown that apart from causing corneal surface changes, 5,6 pterygium may also be associated with degradation of Bowman's layer and stromal scarring 7,8 due to activation of cell proliferation factors, inflammatory mediators, growth factors, extracellular matrix modulators and angiogenic factors. 9 Theoretically, these mediators and UV light may also damage deeper corneal endothelial cells (ECC) and thus corneal endothelial cell density (ECD) may be decreased in eyes with pterygium.…”

Section: -4mentioning

confidence: 99%

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

Atik

et al. 2019

Preprint

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Purpose: To investigate corneal endothelial cell density (ECD) in eyes with primary pterygium. Methods: We first conducted a retrospective study to compare the ECD between 1670 eyes with primary pterygium and 4060 eyes without pterygium. Then we designed a prospective study to confirm the findings of our retrospective study in 95 patients with unilateral primary pterygium. Results: In the retrospective study, the mean ECD in eyes with primary pterygium (2453±306 cells/mm2) was significantly lower than those in eyes without pterygium (2529±313 cells/mm2, P<0.0001). However, the difference was not as high as previously reported (76 cells/mm2, 3.1%). In the prospective study, there was no significant difference in mean ECD in eyes with unilateral primary pterygium (2480±263 cells/mm2) and the contralateral eyes with no pterygium (2527±277 cells/mm2, P=0.20). There was also no significant difference in hexagonality (P=0.10) or coefficient of variation of size (P=0.15) of corneal endothelial cells between eyes with pterygium and the contralateral eyes with no pterygium. Conclusion: Primary pterygium may not be associated with a decrease in ECD in our study population of rural Chinese patients.

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Morphometric characterisation of pterygium associated with corneal stromal scarring using high-resolution anterior segment optical coherence tomography

Abstract: HR-ASOCT is a useful tool for the assessment and monitoring of pterygia in clinical practice. Features associated with increased stromal scarring and astigmatism are reduced thickness of the head of the pterygium and flat bridging of the corneoscleral transition zone.

Cited by 32 publications

References 13 publications

Pattern of corneal astigmatism induced by primary pterygium in patients with cataract in a secondary hospital in Southern China: a cross-sectional study

Pattern of corneal astigmatism induced by primary pterygium in patients with cataract in a secondary hospital in Southern China: a cross-sectional study

New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

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