The aim of the study was to carry out a comparative analysis of the linear size of the uterus in women during the frst period of adulthood and old age according to ultrasound examination data. Material and methods. The study was based on the results of ultrasound examination of 53 women with normal pelvic dimensions who were examined at the gynecology department of the Perm Krai Clinical Hospital during the period from 2021 to 2022. All the women consented to the examination, which was performed according to the indications in order to exclude probable pathology of the reproductive system. The ultrasound examination consisted of measuring the longitudinal (length), transverse (width) and anteroposterior (thickness) dimensions of the uterus using transvaginal access. Women were divided into two groups: the frst group consisted of 27 subjects of the frst period of mature age (22 to 35 years), the second group included 26 subjects of advanced age (75 to 88 years). Results. When comparing the indicators of uterine size, their statistically signifcant decrease from the frst period of adulthood to old age: uterine length decreased by 54.5 % (p < 0.001), width – by 57.8 % (p < 0.001), thickness – by 67.8 % (p < 0.001). We believe that this pattern can be substantiated by the onset of postmenopause and a decrease in estrogenic hormone content from reproductive age to senile age. Conclusions. The obtained results of the intravital comparative analysis of the uterus linear dimensions in women of the frst period of adulthood and old age expand the scientifc ideas about age-related features of this organ of the reproductive system, are the basis for further research and can be used by physicians of clinical specialties such as gynecology, gerontology, ultrasound diagnostics.