Morphometric correlates of anomia in patients with small left temporopolar lesions

Abstract

Visual object naming is a complex cognitive process that engages an interconnected network of cortical regions moving from occipitotemporal to anterior-inferior temporal cortices, and extending into the inferior frontal cortex. Naming can fail for diverse reasons, and different stages of the naming multi-step process appear to be reliant upon the integrity of different neuroanatomical locations. While the neural correlates of semantic errors have been extensively studied, the neural basis of omission errors remains relatively unspecified. Although a strong line of evidence supports an association between anterior temporal lobe damage and semantic errors, there are some studies suggesting that the anterior temporal lobe could be also associated with omissions. However, support for this hypothesis comes from studies with patients in whom damage affected extensive brain regions, sometimes bilaterally. Here, we availed of a group of 12 patients with epilepsy associated with a small lesion at the tip of the left temporal pole. Using an unbiased surface-based morphometry methodology, we correlated two morphological features with errors observed during visual naming. Analyses revealed a correlation between omission errors and reduced local gyrification index in three cortical clusters: one in the left anteromedial temporal lobe region (AMTL) and two in the left

Integrated Clinical Features with Plasma and Multi-modal Neuroimaging Biomarkers to Diagnose Mild Cognitive Impairment in Early Drug-Naive Parkinson’s Disease

“…30 The ACG and temporal lobe are critical structures within a network involved in semantic selection and visual object naming. 31 Besides, the ACG, as part of the salience network (SN), is known to causally affect activation and switch between the DMN and the central executive network, 32,33 and intervened cognitive process by detecting cognitive strife and warning top-downregulated systems. 34 Therefore, the increased connectivity between HF and ACG may predominantly reveal the inability to suppress inappropriate circuits and loss of the normal pattern between SN and DMN in PD-MCI patients.…”