Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period

García, Paula; Barbieri, Mainara Ferreira; Perobelli, Juliana Elaine; Consonni, Sílvio Roberto; Mesquita, Suzana de Fátima Paccola; Kempinas, Wilma De Grava; Pereira, Luís Antônio Violin Dias

doi:10.1016/j.fertnstert.2012.03.025

Cited by 30 publications

(20 citation statements)

References 55 publications

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“…Inhibitors of 5-a reductase, such as finasteride, cause more subtle epididymal changes, only detected morphometrically. 41 The anatomic arrangement of rat efferent ducts (multiple conduits converging on a single outflow tract) predisposes them to occlusion by sloughed debris. Various compounds causing dilation in rat excurrent ducts followed by spermatoceles, sperm granuloma formation, and retrograde fluid pressure and seminiferous tubular atrophy have been described (Figs.…”

Section: Epididymal Changesmentioning

confidence: 99%

Morphologic manifestations of testicular and epididymal toxicity

Vidal¹,

Whitney

2014

Spermatogenesis

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Section: Epididymal Changesmentioning

confidence: 99%

Morphologic manifestations of testicular and epididymal toxicity

Vidal¹,

Whitney

2014

Spermatogenesis

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“…We also speculate that the acceleration of sperm transit reduces the time available for the processes necessary for the maturation of sperm, which can compromise the function of the resulting sperm. 18,49,85 …”

Section: Proliferative Lesions Of the Epididymismentioning

confidence: 99%

Interpreting histopathology in the epididymis

Kempinas

Klinefelter

2014

Spermatogenesis

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“…A study by Garcia et al showed that finasteride-exposed rats experienced deterioration in fertility parameters due to changes in morphology and epididymal and sperm function. The authors explained that finasteride caused an acceleration of sperm transport through the epididymis, which compromised maturation, thereby resulting in decreased fertility [5].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes with Paternal Exposure to Finasteride, a Synthetic 5-Alpha-Reductase Inhibitor: A Case Series

Kh¹,

Shin²,

Hong³

et al. 2015

J Clin Toxicol

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Finasteride (a synthetic 5-alpha-reductase inhibitor) is used for the treatment of male pattern baldness and benign prostatic hyperplasia. There have been few reports on pregnancy outcomes after paternal exposure to finasteride either prior to or during pregnancy. Nineteen cases with documented paternal exposure to finasteride either prior to or during pregnancy were identified through the Korean Motherisk program. Detailed patient histories were obtained and each patient was followed from pregnancy through abortion or delivery. Of the 19 patients, 13 (68.4%) gave birth to normal full-term babies. The other six cases (31.6%) resulted in either spontaneous (n=3) or artificial (n=3) abortions. These results are consistent with previous animal studies demonstrating an increase in adverse outcomes with paternal exposure to finasteride.

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Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period

Cited by 30 publications

References 55 publications

Morphologic manifestations of testicular and epididymal toxicity

Morphologic manifestations of testicular and epididymal toxicity

Interpreting histopathology in the epididymis

Pregnancy Outcomes with Paternal Exposure to Finasteride, a Synthetic 5-Alpha-Reductase Inhibitor: A Case Series

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