Morphometrical changes in the apical surface of the colonic absorptive cells in perinatal rats with special reference to the effect of fetal oral administration of milk <i>in utero</i>

Morikawa, Yoshio; Fujimoto, Kazuya; Okada, Toshiya

doi:10.1258/002367791780808347

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…As reviewed in section IIA, the intestinal development is associated not only with the growth of the intestine but also with marked changes of intestinal villi in the small intestine and a transient appearance of villuslike structure in the proximal colon. Furthermore, postnatal development of enterocytes is associated with amplification of the surface of microvilli (apical membrane) and of the basolateral membrane (265,413). The developmental changes of surface area are influenced by rapid growth of intestinal mucosa that is predetermined in altricial species by decreased cell turnover (202).…”

Section: A Adaptive Mechanisms During Early Developmentmentioning

confidence: 99%

Development of Intestinal Transport Function in Mammals

Pácha

2000

Physiological Reviews

340

281

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Considerable progress has been made over the last decade in the understanding of mechanisms responsible for the ontogenetic changes of mammalian intestine. This review presents the current knowledge about the development of intestinal transport function in the context of intestinal mucosa ontogeny. The review predominantly focuses on signals that trigger and/or modulate the developmental changes of intestinal transport. After an overview of the proliferation and differentiation of intestinal mucosa, data about the bidirectional traffic (absorption and secretion) across the developing intestinal epithelium are presented. The largest part of the review is devoted to the description of developmental patterns concerning the absorption of nutrients, ions, water, vitamins, trace elements, and milk-borne biologically active substances. Furthermore, the review examines the development of intestinal secretion that has a variety of functions including maintenance of the fluidity of the intestinal content, lubrication of mucosal surface, and mucosal protection. The age-dependent shifts of absorption and secretion are the subject of integrated regulatory mechanisms, and hence, the input of hormonal, nervous, immune, and dietary signals is reviewed. Finally, the utilization of energy for transport processes in the developing intestine is highlighted, and the interactions between various sources of energy are discussed. The review ends with suggestions concerning possible directions of future research.

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Section: A Adaptive Mechanisms During Early Developmentmentioning

confidence: 99%

Development of Intestinal Transport Function in Mammals

Pácha

2000

Physiological Reviews

340

281

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“…As aldosterone treatment for 7 days is sufficient to observe ultrastructural changes of cell membranes (Wade et al 1990), it is clear that the absence of the aldosterone effect on S v (ap) in our experiments was not influenced by the time course action of aldosterone. The absence of changes in the colonic apical membrane ultrastructure is particularly interesting because weaning is associated with an enlargement of apical membrane area in absorptive duodenal cells (Overton 1965), and an increase in the colonic apical amplification factor was observed during the perinatal period (Morikawa et al 1991).…”

Section: Groupmentioning

confidence: 99%

Correlation of function and structure in developing rat distal colon

Vagnerová

Kubínová

Pácha

1997

Cell and Tissue Research

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The distal colon of suckling (14-day-old) and weanling (27-day-old) rats absorbs Na+ via channel-mediated, electrogenic amiloride-sensitive Na+ transport which disappears after weaning. This transport pathway is induced by aldosterone in superficial cells of colonic epithelium. The purpose of the present study was to correlate the changes in distal colon function with changes in the apical and basolateral cell membrane surface areas of superficial enterocytes. The basolateral but not apical membrane surface density (i.e. surface areas of the basolateral and apical membranes of superficial enterocytes per unit volume of superficial enterocytes) was found to increase between postnatal day 14 and 27 (i.e. during the weaning period). The plasma concentrations of aldosterone were very high during this period and electrogenic amiloride-sensitive Na+ transport and Na, K-ATPase activity were increased significantly. High dietary salt intake during the weaning period prevented the developmental increase of basolateral membrane surface density, inhibited electrogenic amiloride-sensitive Na+ transport and significantly depressed plasma aldosterone levels and Na, K-ATPase activity. Apical cell membrane surface density did not change significantly after a sodium load. Thus, high plasma concentrations of aldosterone and/or high colonic Na+ transport during weaning exert an important and selective effect on the basolateral membrane and are responsible for the developmental changes of this cell membrane surface during weaning. Concomitant changes in the morphology of superficial colonic enterocytes and in colonic Na+ transport suggest that the structure of the immature epithelium is related to its function.

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Molecular Physiology of Gastrointestinal Function during Development

Xu¹,

Collins²

2012

Physiology of the Gastrointestinal Tract

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Morphometrical changes in the apical surface of the colonic absorptive cells in perinatal rats with special reference to the effect of fetal oral administration of milk in utero

Cited by 5 publications

References 6 publications

Development of Intestinal Transport Function in Mammals

Development of Intestinal Transport Function in Mammals

Correlation of function and structure in developing rat distal colon

Molecular Physiology of Gastrointestinal Function during Development

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