Morphometry analysis of psoriasis and psoriasiform dermatitis: A retrospective study of 50 cases

Chanadanwale, Shirish S; Panicker, N K; Kulkarni, Sushmah P; Shah, Komal R; Kumar, Harsh; Pal, Sukanya

doi:10.4103/0975-2870.148843

Cited by 5 publications

(16 citation statements)

References 1 publication

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“…In the present study, acanthosis (regular epidermal hyperplasia) was present in 96.1% of biopsies. Our results are in concordance with other studies in which acanthosis was observed in about 75% or more biopsies [3,14,17,19,22]. However, Park JH et al reported lesser prevalence of this feature (46.7%) as compared to other authors as well as the present study [20].…”

Section: Discussionsupporting

confidence: 93%

“…However, Park JH et al reported lesser prevalence of this feature (46.7%) as compared to other authors as well as the present study [20]. histopathological diagnosis of psoriasis which was not a consistent finding in our study [19]. In the present study, suprapapillary thinning was noted in 41.5% biopsy samples, findings similar to the studies conducted by Mehta S et al and Puri N et al [3,17].This finding is in contrast to other studies which reported variable prevalence of this feature [15,20,22].…”

Section: Discussioncontrasting

confidence: 90%

“…Similar results have been observed in previous studies which reported presence of agranulosis/ hypogranulosis in 68% -100% cases. In contrast, a study conducted by Chandanwale SS et al found agranulosis in 32% cases [19]. The cause for absent granular layer or decreased/hypo granular layer is not known.…”

Section: Discussionmentioning

confidence: 85%

“…Puri N et al found marginally higher cases of psoriasis vulgaris (32%) than guttate psoriasis (28%) followed by erythrodermic psoriasis (16%) and similar incidence of generalized pustular and palmoplantar psoriasis (12%) [17]. [15,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…In our study the spongiosis was present in 10.8% biopsies. Mehta [14,19,21] They reported dilated blood vessels in dermal papillae in 98% and 100% and 90% cases respectively. The studiesby Mehta S et al and Puri N et al reported this feature in 80% and 54% cases respectively [3,17].…”

Section: Discussionmentioning

confidence: 99%

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The spectrum of histomorphological features in psoriasis: a three years study

Arora

Mittal

Ahmad

et al. 2019

Trop J Pathol Microbiol

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Introduction: Psoriasis is a common relapsing chronic inflammatory dermatological disease associated with significant morbidity. Psoriasis is the prototype of a group of cutaneous disorders (psoriasiform dermatitides). Although histopathology is considered 'gold standard' for the diagnosis of psoriasis, at times even histopathological findings are confusing and inconclusive. Aim of the study: To study the histopathological findings at different stages of psoriasis and its subtypes. Materials and Methods: A total of 101 cases were studied for histopathological features. Results: Most of the cases were noted in the age group of 31 to 40 years (25.9%). There was a male predominance with male to female ratio of 2.7:1. Psoriasis vulgaris was the most common clinical type followed by Palmoplantar psoriasisand Erythrodermic psoriasis. Parakeratosis was the only consistent feature followed by ddilated blood vessels/abnormal capillary pattern and elongation of rete ridges with thickening at lower ends. The other frequent features were acanthosis and agranulosis / hypogranulosis. Conclusion: Histopathology of psoriatic plaques exhibits heterogeneity and microscopic features will vary according to the stage of the disease. Though most of the predominant morphologic features of psoriasis are related to the epidermis, the presence of dilated blood vessels and/or abnormal capillary pattern is a constant finding in all stages of psoriasis and thus, can help in diagnosis of psoriatic lesion when in doubt.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The spectrum of histomorphological features in psoriasis: a three years study

Arora

Mittal

Ahmad

et al. 2019

Trop J Pathol Microbiol

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Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis

Ramezani¹,

Shamshiri²,

Zavattaro³

et al. 2019

BioMedicine

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Background: Psoriasis is the prime example of psoriasiform tissue pattern and should be differentiated from other psoriasiform dermatoses both clinically and histopathologically.Aim: To evaluate immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis for diagnostic purposes.Methods: An analytical cross-sectional study was performed on the paraffin blocks of 60 psoriasis and 31 psoriasiform dermatitis patients between 2014 and 2017. The selected formalin-fixed paraffin-embedded tissues from each biopsy specimen were cut into 4-micron sections. Initial sections were stained by hematoxylin and eosin staining. Primary antihuman antibodies against P53, Ki-67, and CD34 were applied. Positive control samples for biomarkers were received from former strongly positive samples of papillary endothelial hyperplasia, high grade lymphoma, and breast ductal carcinoma for CD34, Ki-67, and P53, respectively.Results: Out of 60 psoriasis patients, 56.7% were men, with the mean age of 36.8 years. From 31 psoriasiform patients, 45.2% were men, with the mean age of 37.5 years. Both groups were matched in terms of sex and age. The mean staining of three markers was more significant in psoriasiform dermatitis than psoriasis.Conclusion: In spite of some other researches, the present study showed expression of P53, Ki-67, and CD34 biomarkers were significantly higher in psoriasiform dermatitis than psoriasis.

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Relationship between histomorphological findings and platelet activation in psoriasis

Karanis

Küçükosmanoğlu

Oltulu

et al. 2022

J of Cosmetic Dermatology

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Psoriasis is a chronic disease accompanied by local and systemic inflammation affecting approximately 2% of the population worldwide. 1 Psoriasis is assumed as a systemic condition rather than a disease limited to the skin due to systemic inflammation and accompanying comorbidities. 2 Platelets, which are known to have critical importance in systemic inflammatory pathways, are thought to play a role in the etiopathogenesis of psoriasis. 3 Platelet count (PC) is shown to increase significantly in patients with psoriasis. 4 In

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Morphometry analysis of psoriasis and psoriasiform dermatitis: A retrospective study of 50 cases

Cited by 5 publications

References 1 publication

The spectrum of histomorphological features in psoriasis: a three years study

The spectrum of histomorphological features in psoriasis: a three years study

Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis

Relationship between histomorphological findings and platelet activation in psoriasis

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