Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats

Liu, Tingting; Sun, Fuming; Cui, Jiamin; Zheng, Songyang; Li, Zijie; Guo, Dongze; Tian, Xin; Zhu, Zexuan; Zheng, Wenjian; Wang, Yufeng; Wang, Wen

doi:10.1016/j.ejphar.2020.172954

Cited by 28 publications

(20 citation statements)

References 32 publications

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“…Furthermore, the morroniside treatment also increased the amount of BrdU + cells and cell viability following OGD. These results support our previous findings that morroniside enhances in-vivo angiogenesis [ 6 ]. Based on the general concept, ECs migration is an essential component of angiogenesis [ 14 ].…”

Section: Discussionsupporting

confidence: 93%

“…Formation of RCAECs. We previously demonstrated that morroniside increased the number of Ki67 + RCAECs in vitro [6]. Ki67 immunohistochemistry, on the other hand, can only yield information on the proliferative state of the cells because Ki67 is expressed in all phases of the cell cycle except for G0 [9].…”

Section: Morroniside Regulates Proliferation Viability and Tubementioning

confidence: 99%

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Morroniside Regulates Endothelial Cell Function via the EphrinB Signaling Pathway after Oxygen-Glucose Deprivation In Vitro

Liu

Zheng

Sun

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Proangiogenic treatment is a potential treatment for acute myocardial infarction (AMI). Morroniside was previously discovered to increase post-AMI angiogenesis in rats as well as the proliferation of rat coronary artery endothelial cells (RCAECs). However, the effects of morroniside on other endothelial cell (EC) functions and underlying mechanisms are unknown. To further clarify the vascular biological activity of morroniside, this work focused on investigating how morroniside influenced endothelial cell functions, such as cell viability, tube formation capacity, migration, and adhesion, and to explore the signaling pathway. Oxygen-glucose deprivation causes ischemic damage in RCAECs (OGD). In vitro investigations were carried out to explore the involvement of morroniside in EC function and pathways mediated by ephrinB. The results revealed that the number of BrdU+ cells and cell viability in the high-dose group were considerably greater than in the OGD group ( P < 0.05 ). The ability of tube formation evaluated by total tube length, tube-like structural junction, and tube area was significantly higher in the morroniside group than in the OGD group ( P < 0.001 ). Morroniside considerably improved migration and adhesion abilities compared to OGD group ( P < 0.05 , P < 0.01 , P < 0.001 ). The protein expression levels of the ephrinB reverse signaling pathway were substantially greater in the morroniside group than in the OGD group ( P < 0.05 , P < 0.01 ). In conclusion, the current study demonstrated that morroniside modulates endothelial cell function via ephrinB reverse signaling pathways and provided a novel insight and therapeutic strategy into vascular biology.

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Section: Discussionsupporting

confidence: 93%

Section: Morroniside Regulates Proliferation Viability and Tubementioning

confidence: 99%

Morroniside Regulates Endothelial Cell Function via the EphrinB Signaling Pathway after Oxygen-Glucose Deprivation In Vitro

Liu

Zheng

Sun

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…It has therapeutic effects in multiple organs and their systems [ 177 , 178 ]. Morroniside shows therapeutic results in rats after acute myocardial infarction by promoting angiogenesis and improved heart function [ 179 ]. It also prevents apoptosis of cardiomyocytes induced by high glucose [ 180 ].…”

Section: Monoterpenesmentioning

confidence: 99%

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Miclea

2022

IJMS

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Carnivorous plants have fascinated researchers and hobbyists for centuries because of their mode of nutrition which is unlike that of other plants. They are able to produce bioactive compounds used to attract, capture and digest prey but also as a defense mechanism against microorganisms and free radicals. The main purpose of this review is to provide an overview of the secondary metabolites with significant biological activity found in the Sarraceniaceae family. The review also underlines the necessity of future studies for the biochemical characterization of the less investigated species. Darlingtonia, Heliamphora and Sarracenia plants are rich in compounds with potential pharmaceutical and medical uses. These belong to several classes such as flavonoids, with flavonol glycosides being the most abundant, monoterpenes, triterpenes, sesquiterpenes, fatty acids, alkaloids and others. Some of them are well characterized in terms of chemical properties and biological activity and have widespread commercial applications. The review also discusses biological activity of whole extracts and commercially available products derived from Sarraceniaceae plants. In conclusion, this review underscores that Sarraceniaceae species contain numerous substances with the potential to advance health. Future perspectives should focus on the discovery of new molecules and increasing the production of known compounds using biotechnological methods.

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“…Cornus officinalis is among the most commonly used Chinese medical herbs, and morroniside (Figure 1(a)) is the most abundant iridoid glycoside in C. officinalis [17]. It has a variety of biological activities, such as antioxidant, antiapoptotic, and anti-inflammatory effects [18][19][20], which can relieve nerve pain and improve cardiovascular and liver functions [21,22]. Deng et al [23] showed that morroniside inhibited autophagy in rat ovarian GCs by regulating the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway.…”

Section: Introductionmentioning

confidence: 99%

Morroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways

Hao

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Morroniside is the main ingredient of Cornus officinalis and has a variety of biological activities including antioxidative effects. Ovarian granulosa cells (GCs) are responsible for regulating the development and atresia of follicles, which are susceptible to oxidative stress. In this study, we determined whether morroniside can inhibit the oxidative stress of GCs induced by hydrogen peroxide (H2O2), leading to improved oocyte quality. The oxidative damage and apoptosis of ovarian GCs cultured in vitro were induced by the addition of H2O2. After pretreatment with morroniside, the levels of ROS, MDA, and 8-OHdG in ovarian GCs were significantly decreased. Morroniside significantly upregulated p-Nrf2 and promoted the nuclear translocation of Nrf2, which transcriptionally activated antioxidant SOD and NQO1. In addition, morroniside significantly regulated the levels of apoptosis-related proteins Bax, Bcl-2, cleaved caspase-9, and cleaved caspase-3 via the p38 and JNK pathways. These results suggest that morroniside can reduce the oxidative damage and apoptosis of ovarian GCs induced by H2O2.

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Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats

Cited by 28 publications

References 32 publications

Morroniside Regulates Endothelial Cell Function via the EphrinB Signaling Pathway after Oxygen-Glucose Deprivation In Vitro

Morroniside Regulates Endothelial Cell Function via the EphrinB Signaling Pathway after Oxygen-Glucose Deprivation In Vitro

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Morroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways

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