Mortalidad de los pacientes covid-19 con complicaciones trombóticas

González-Fajardo, J.A.; Ansuátegui, Marina; Romero, Carmen; Comanges, Alejandra; Gómez-Arbeláez, Diego; Ibarra, Gorka; García-Gutiérrez, Ania

doi:10.1016/j.medcli.2020.10.004

Cited by 13 publications

(2 citation statements)

References 20 publications

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“…Along with ground-glass opacities with pneumonia, a hypercoagulable state and thrombotic complications have been frequently associated with COVID-19; venous thromboembolism being the more common type of thrombosis found in patients with COVID-19. Although the appropriate timing to screen in-patients with COVID-19 for deep vein thrombosis of the lower limbs is still a matter of debate [ 11 , 12 ], such an association impacts on the outcome of inpatients anyway [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ] Then, in order to detect deep- or superficial-vein thrombosis, we choose to perform vascular imaging of the lower limbs also in patients with COVID-like syndrome.…”

Section: Discussionmentioning

confidence: 99%

Clinical Differences between COVID-19 and a COVID-Like Syndrome

Micco

Camporese

Russo

et al. 2021

JCM

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COVID-19 is an infection due to SARS-CoV-2; this virus has been identified as the cause of the present pandemic. Several typical characteristics are present in this infection, in particular pneumonia with possible lung failure, but atypical clinical presentations are being described daily by physicians around the world. Ground-glass opacities with pneumonia are the most common and dangerous presentations of the COVID-19 disease, and they are usually associated with positive nasopharyngeal swab (NPS) tests with detectable SARS-CoV-2 viral RNA. Compared to the general population, hospital workers have been at a greater risk of infection ever since the first patients were hospitalized. However, hospital workers have also been reported as having COVID-like symptoms despite repeated negative swab tests but having tested positive for SARS-CoV-2 antibodies with serological tests. We can postulate that a COVID-like syndrome is possible, in particular in hospital workers, that is characterized by symptoms similar to those of COVID-19, but with repeated negative nasopharyngeal swabs. These repeated negative NSPs make the difference in daily clinical management with people that experienced a single false negative nasopharyngeal swab; furthermore, a clear clinical differentiation of these situations is still lacking in the literature. For this reason, here, we report our main findings from a cohort of patients with a COVID-like syndrome compared to a similar group affected by typical COVID-19.

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Section: Discussionmentioning

confidence: 99%

Clinical Differences between COVID-19 and a COVID-Like Syndrome

Micco

Camporese

Russo

et al. 2021

JCM

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“…(7,8) Las enfermedades trombóticas ocasionadas por el COVID-19 se han atribuido al elevado componente inflamatorio, a la hipercoagulabilidad, la activación plaquetaria, el daño endotelial y la estasis sanguínea, además se ha identificado que el riesgo trombótico venoso es mayor al arterial en una relación de 73,6 % -26,4 % respectivamente, pero cuando el de tipo arterial se presenta tiene peor evolución y una mayor mortalidad. (9) Los factores de riesgo para desarrollar TEP son algo inespecíficos y muchos de estos representarán un riesgo franco para la presentación de TEP asociada a COVID-19, sin embargo, varían entre pacientes y es por esto que no se puede generalizar quienes van a presentar esta complicación y quienes van a ser esquivos a la misma, a pesar de esto se debe conocer dichos factores y tenerlos en cuenta en todo momento. (6,10) Existen múltiples factores de riesgo con influencia en la presentación de TEP relacionado a COVID-19, así por mencionar algunos se sabe que los pacientes que precisan ingreso a UCI tienen un mayor riesgo de desarrollar TEP que aquellos pacientes que se mantienen en planta de hospitalización, (11,12) el aumento de dímero D (DD) se ha visto también asociado con patología trombótica además de relacionarse a un mayor índice de mortalidad, así también la presencia de comorbilidades como la obesidad aumenta el riesgo de contagio y la necesidad de intubación, (11,13,14) incluso a cierta edad se aumenta el riesgo embolias venosas y debe ser considerado como un factor a tomar en cuenta.…”

Section: Introductionunclassified

Risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19

Gaona

Cajamarca

Palomeque

et al. 2022

Salud, Ciencia y Tecnología

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Introducción: La infección por COVID-19 abarca varias manifestaciones clínicas que van desde tos, fiebre, mialgias, disnea, fatiga y rinorrea hasta una infección asintomática en algunos de los casos, a esto se suma y gana importancia como una complicación del COVID-19 las enfermedades de la coagulación entre las que encontramos el tromboembolismo pulmonar (TEP), de hecho se ha logrado identificar pacientes que han llegado a fallecer por esta causa asociada a la infección por SARS-CoV-2.Objetivo: Describir los factores de riesgo asociados al desarrollo de tromboembolismo pulmonar en pacientes adultos con diagnóstico de COVID-19.Métodos: revisión bibliográfica narrativa en donde se incluyó meta-análisis, revisiones sistemáticas, artículos de revisión y artículos de investigación publicadas en PubMed y Web of Science entre los años 2020-2022.Conclusiones: se determinó que existen factores de riesgo que propician el desarrollo de TEP asociado a COVID-19, de los cuales mencionamos algunos como la edad, el ingreso a unidades de cuidados intensivos (UCI) e incluso el sexo del paciente, cabe recalcar que cada uno de estos se encuentra relacionado en mayor o menor medida por lo que deben ser considerados y asociados teniendo en cuenta esa distinción.

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Editor's Choice – Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature

Jongkind

Earnshaw

Gonçalves

et al. 2022

European Journal of Vascular and Endovascular Surgery

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Objectives Perform a scoping review how COVID-19 patients are affected by acute limb ischaemia (ALI). Evaluate the recommendations of the 2020 ESVS ALI Guidelines for these patients. Methods Research questions were defined, followed by a systematic literature search according to the PRISMA guideline. Abstracts and unpublished literature were not included. The definition of ALI accords to ESVS guidelines. Results Most identified papers were case reports or case series; population-based data and data from randomised controlled trials were also identified, 114 unique and relevant papers were retrieved. Data were conflicting concerning whether the incidence of ALI increased, or remained unchanged, during the pandemic. Case reports and series reported ALI in patients who were younger and healthier than usual, and a greater proportion affecting the upper limb. Whether this is coincidental remains uncertain. The proportion of men/women affected seems unchanged. Most reported cases were in hospitalised patients with severe COVID-19. Patients with ALI as their first manifestation of COVID-19 were reported. Patients with ALI have a worse outcome if they have a simultaneous COVID-19 infection. High levels of D-dimer may predict the occurrence of arterial thromboembolic events in patients with COVID-19. Heparin resistance was observed. Anticoagulation should be given to hospitalized COVID-19 patients in prophylactic dosage. Most of the treatment recommendations of the ESVS Guidelines remained relevant, but the following were modified regarding COVID-19 patients with ALI: 1) CTA imaging before revascularisation should include the entire aorta and iliac arteries. 2) There should be a high index of suspicion, early testing for COVID-19 infection and protective measures are advised. 3) Preferential use of local or locoregional anaesthesia during revascularisation. Conclusion Although the epidemiology of ALI has changed during the pandemic, the recommendations of the ESVS ALI Guidelines remain valid. The above mentioned minor modifications should be considered in COVID-19 patients with ALI.

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Mortalidad de los pacientes covid-19 con complicaciones trombóticas

Cited by 13 publications

References 20 publications

Clinical Differences between COVID-19 and a COVID-Like Syndrome

Clinical Differences between COVID-19 and a COVID-Like Syndrome

Risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19

Editor's Choice – Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature

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