Mortalité des enfants drépanocytaires dans un service de pédiatrie en Afrique Centrale

Koko, J.; Dufillot, D; M'Ba-Meyo, J; Gahouma, D.; Kani, F.

doi:10.1016/s0929-693x(98)80003-1

Cited by 25 publications

(11 citation statements)

References 5 publications

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“…Our previous investigations [8] [9] had already demonstrated that these locations were affected relative infrequently among individuals in Gabon with SCD. These observations were substantiated by Thuillez et al in a cohort of nearly 300 patients [6].…”

Section: Discussionmentioning

confidence: 90%

Fever among Children with Sickle-Cell Disease: Findings from the General Pediatric Ward of the Owendo Pediatric Hospital in Libreville, Gabon

Koko¹,

Gahouma²,

Ategbo³

et al. 2014

OJPed

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Sickle-cell disease (SCD) represents a substantial public health problem in Gabon. Fever is one of the principal reasons for the hospitalization of children afflicted by major sickle-cell disorder, since it can be a clinical reflection of severe infections that have the potential to become life threatening. Objectives: Identification of the main causes of fever in children with SCD in our clinical setting, with the aim of optimizing treatments. Patients and Methods: This is a retrospective study of all the medical files for children with SCD that were admitted to our ward, over a two year period, due to fever (>38.5˚C) lasting more than 24 hours. Only those files that contained at least the following five fundamental medical examinations were retained for further evaluation: Complete Blood Count (CBC), blood smear, blood culture, urine culture and chest X-ray. Out of a total of 118 admissions (103 patients), 87 (73.7%) were due to the incidence of fever. The medical files of 11 patients were deemed to be unusable. Seventy-six episodes of fever were observed among 69 children, of which 42 were male and 27 female (sex ratio of 1.5). Among these, seven (10%) were admitted twice. Results: The age groups that were most affected included 12 -18 year-olds (30 cases: 43.5%) and 6 -12 year-olds (26 cases: 37.7%). The most common accompanying symptoms were bone and joint pain (43.4%), asthenia (22.4%), cough (19.7%), vomiting (17%) and headache (15.8%). The specific cause of the fever could not be pinpointed in 29 cases (38.1%). Aside from these cases, the main causes of fever were malaria (30.3%) and bronchopulmonary infections (22.4%). The white blood cell count was >20,000/mm 3 in 47% of respiratory infections, 43.5% of the cases involving malaria and 55.2% of cases of fever with unknown cause. Hemoglobin levels * Corresponding author. J. Koko et al. 263were <5g/dl for 52.2% of the cases involving malaria and 22.6% for those of unknown origin. For four patients, all less than 10 years of age, the disease was fatal. Conclusion: For the majority of fever episodes, the underlying cause could not be determined. Nonetheless, malaria was identified as one of the principal identifiable causes of fever among children with SDC in Libreville. Treatment for malaria upon admission, and the promotion of preventative measures, therefore seems to be appropriate for our clinical setting. In light of the large number of unresolved cases, systematic prescription of broad-spectrum antibiotics may also be called for.

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Section: Discussionmentioning

confidence: 90%

Fever among Children with Sickle-Cell Disease: Findings from the General Pediatric Ward of the Owendo Pediatric Hospital in Libreville, Gabon

Koko¹,

Gahouma²,

Ategbo³

et al. 2014

OJPed

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“…The peak frequency of death was observed in 2015 at 18.09% (n=43) and in children under 15 years of age (n=96) whose average age was 9.25 years. Koko J and al, in a study carried out in Gabon on the mortality of sickle cell children in a pediatric unit in Central Africa reported that the majority of deaths concerned children under 15 years old in 60.9% of cases [12]. This tendency is found in many studies, it was 68.4% in the series of Seeler,33.3% age [4,8,13].…”

Section: Discussionmentioning

confidence: 95%

Observation of Causes of Death from Sickle Cell Anemia in Niger

A¹,

M²,

Chefou³

et al. 2021

annhematoloncol

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Purpose: Improve the management of Major Sickle Cell Syndromes (SDM) by studying the circumstances in which patients affected by this disease die in Niger. Methods: This was a retrospective study of descriptive and analytical type in sickle cell patients followed at the National Sickle Cell Reference Center (CNRD) in Niamey with a follow-up file, who died during our study period, which was 9 years (January 1, 2010 to December 31, 2018). Results: During the study period, 6,465 sickle cell patients were followed up at the CNRD, 249 deaths were recorded, representing a frequency of 3.8%. There is a male predominance with a sex ratio of 1:3. The 0-15 age group was the most represented with 34.5% with an average age of 9.25 years. 34.1% of the patients came from a consanguineous marriage. Of the 249 deaths, 94% (n=234) were SS, 5.6% (n=14) were SC and 0.4% (n=1) was S/β. The majority of patients died at the time of registration, i.e. 58.25% (n=145 (SS=137. SC=8.)). 90.4% had died in a health-care facility. The main cause of death was anemia in 73.1% of cases. Conclusion: The management of sickle cell disease requires adequate preventive action to reduce the rate of early mortality.

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“…However, anemia is observed at 96.35% in this age group (Table 4). It is an age group vulnerable to infections such as malaria responsible for severe anemia in children and deaths in sickle cell anemia at this age were due to severe anemia (47.8%) 25 . Among women aged 1 to over 35, an average of 64.42% are anemic.…”

Section: Discussionmentioning

confidence: 99%

“…Traore MS, Zohoncon TM, Ouedraogo P, Ouattara AK, Obiri-Yeboah D, Tao I, Ganane G, Belemgnegre M, Boro T, Sanou F, Simpore J. Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies. J Human Clin Gen (2019);2(1): [23][24][25][26][27][28][29][30] Journal of Human and Clinical Genetics of medical care for sickle cell patients. The study made it possible to diagnose for the first time with the improvement of the technical platform of the laboratories, the AE, AO-Arabic, SO-Arabic genotypes at HOSCO, Burkina Faso.…”

Section: Figure 1: Hemoglobin Electrophoretic Profilesmentioning

confidence: 99%

Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies

Traoré¹,

Zohoncon²,

Ouédraogo³

et al. 2020

J Human Clin Gen

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Introduction:The prevalence of hemoglobinopathies (HbC and HbS) is relatively high in West Africa, especially in Burkina Faso. The objectives of this study were to characterize the hematological parameters and to determine the genotypic and allelic frequencies of patients affected with hemoglobinopathies.Methods: Hemoglobin electrophoresis was carried out in a total of 7,789 patients attending Saint Camille Hospital of Ouagadougou during the period of study. Among them, hemogram was performed for 1014 patients. Results:The age of the study population ranged from 1 to 40 years, with a mean of 24.86 ± 12.69 years. The age group 16 to 35 were the most seen at medical center hospital and represented 3,035 out of 7,789 (38.96 %) having performed hemoglobin electrophoresis. The overall hemoglobin electrophoretic profiles revealed 223 SS, 718 SC, 2 SO-Arab, 2 AO-Arab, 3 AE, 152 CC, 799 AS, 1315 AC, and 4575 AA. The relative genotypic frequency was 58.73 % AA, 2.86 % SS and 9.22 % SC while the allelic frequencies were 0.7234 for HbA, 0.1500 for HbC, 0.1261 for HbS, 0.0002 for HbE and 0.0003 for HbO-Arab. The hemogram profiles of patients with major sickle cell syndrome (MSCS) revealed respectively for mean hemoglobin levels, number of red blood cells and mean corpuscular volume a values of 8.19 ± 1.39 g/dL ; 2.97 ± 0.73 10 12 /L ; 81.86 ± 12.82 fL in SS patients and 10.93 ± 1.68 g/dL ; 4.38 ± 0.77 10 12 /L ; 70.81 ± 7.11 fL in SC individuals. Conclusion:The results of the present study are in line with the previous one describing the high prevalence of HbC and HbS hemoglobinopathies in Burkina Faso. Indeed, the genotypic and allelic frequencies of patients with MSCS are increasing due to the accessibility of medical care for sickle cell patients. The study diagnoses for the first-time hemoglobin AE, AO-Arab and SO-Arab genotypes in Burkina Faso.

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Mortalité des enfants drépanocytaires dans un service de pédiatrie en Afrique Centrale

Cited by 25 publications

References 5 publications

Fever among Children with Sickle-Cell Disease: Findings from the General Pediatric Ward of the Owendo Pediatric Hospital in Libreville, Gabon

Fever among Children with Sickle-Cell Disease: Findings from the General Pediatric Ward of the Owendo Pediatric Hospital in Libreville, Gabon

Observation of Causes of Death from Sickle Cell Anemia in Niger

Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies

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