Mortality after hospital admission for heart failure: improvement over time, equally strong in women as in men

Abstract

Background: To assess the trend in age-and sex-stratified mortality after hospitalization for heart failure (HF) in the Netherlands. Methods: Two nationwide cohorts of patients, hospitalized for new onset heart failure between 01.01.2000-31.12.2002 and between 01.01.2008-31.12.2010, were constructed by linkage of the Dutch Hospital Discharge Registry and the National Cause of Death registry. 30-day, 1-year and 5-year overall and cause-specific mortality rates stratified by age and sex were assessed and compared over time. Results: We identified 40,230 men and 41,582 women. In both cohorts, men were on average younger than women (74-75 and 78-79 years, respectively) and more often had comorbid conditions (37 and 30%, respectively). In the 2008-10 cohort, mortality rates for men were 13, 32 and 64% for respectively 30-day, 1-year and 5-year mortality and 14, 33 and 66% for women. Mortality rates increased considerably with age similarly in men and women (e.g. from 10.5% in women aged 25-54 to 46.1% in those aged 85 and older after 1 year). Between the two time periods, mortality rates dropped across all ages, equally strong in women as in men. The 1-year absolute risk of death declined by 4.0% (from 36.1 to 32.1%) in men and 3.2% (from 36.2 to 33.0%) in women. Conclusions: Mortality after hospitalization for new onset HF remains high, however, both short-term and long-term survival is improving over time. This improvement was similar across all ages and equally strong in women as in men.

Remote Monitoring in Chronic Heart Failure Patients: Is Non-Invasive Remote Monitoring the Way to Go?

“…So was the percentage of studies that included patients who were hospitalized due to HF (e.g., unstable HF patients) lower in studies who did not report a beneficial effect of structured telephone support or non-invasive remote monitoring on the all-cause mortality, all-cause hospitalization, or HF-related hospitalization rates. Hospitalization for HF is associated with an increased risk for mortality as well as rehospitalizations [ 5 , 74 ]. In these unstable HF patients, non-invasive remote monitoring has the largest potential to improve their clinical outcomes and reduce the HF-related hospitalization rates.…”

“…Timely detection of congestion due to HF can prevent HF-related hospitalization, reduce the overall burden on health care resources, and improve patient outcomes [ 5 , 6 ]. Remote monitoring could be a crucial tool for the early detection of deterioration of HF.…”

Albuminuria and Dipstick Proteinuria for Predicting Mortality in Heart Failure: A Systematic Review and Meta-Analysis

“…Traditional risk factors like diabetes, hypertension, smoking, and hyperlipidemia are well-recognized for predicting mortality with cardiovascular diseases (3,4). Studies have also reported that albuminuria not only is an independent risk factor for the development of cardiovascular disease but also acts as a biomarker for predicting mortality in such patients (5)(6)(7).…”

Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China

“…Depending on extent of the decline in left ventricular ejection function (LVEF), HF is typically classified into heart failure with preserved ejection fraction (HFpEF) and with reduced ejection fraction (HFrEF) types. However, patients with HF have poor prognosis regardless of the LVEF, with a poor survival rate of < 50% within 5 years after the first hospitalization ( Tribouilloy et al, 2008 ; Buddeke et al, 2020 ). In addition, almost half of the HF patients suffer from fatigue, breathlessness, edema or arrhythmias, which significantly reduces the quality of life ( Gohler et al, 2009 ).…”