2017
DOI: 10.1002/jbmr.3216
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Mortality After Osteoporotic Fractures: What Proportion Is Caused by Fracture and Is Preventable?

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Cited by 31 publications
(23 citation statements)
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References 81 publications
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“…Even with this decline, the MR was higher for all time points compared to the non‐NTFx groups. This finding is consistent with the conviction that there may be a unique set of factors associated with short‐ and long‐term mortality post‐NTFx . However, the mechanisms explaining the NTFx‐induced mortality have yet to be elucidated and may be further confounded by the medical complexities of epilepsy (eg, antiseizure medications).…”
Section: Discussionsupporting
confidence: 87%
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“…Even with this decline, the MR was higher for all time points compared to the non‐NTFx groups. This finding is consistent with the conviction that there may be a unique set of factors associated with short‐ and long‐term mortality post‐NTFx . However, the mechanisms explaining the NTFx‐induced mortality have yet to be elucidated and may be further confounded by the medical complexities of epilepsy (eg, antiseizure medications).…”
Section: Discussionsupporting
confidence: 87%
“…Prefracture diseases, functional capacity, and physical ability (eg, muscle strength) are risk factors for postfracture premature mortality, and a follow‐up fracture further exacerbates mortality risk . The systemic stress induced by an NTFx may create an unfavorable physiological environment that exacerbates risk for post‐NTFx complications and premature mortality, through either direct or indirect mechanisms . Individuals with epilepsy are particularly susceptible to post‐NTFx complications because of their greater lifetime burden of unhealthful aging, as evidenced by an elevated prevalence of chronic diseases in adulthood .…”
Section: Discussionmentioning
confidence: 99%
“…Fractures are a high‐burden condition that increases the risk for premature mortality . While the cause and effect has yet to be unraveled, sustaining a low‐trauma fracture may exert its effect on premature mortality directly or indirectly through post‐fracture development of chronic diseases, especially CVD . In a cohort study from England, Ryan et al reported that the median age of death for adults with CP was 40 years with a threefold increased risk for CVD‐related death.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, adjuvant aromatase inhibitors may be given for ten years or more. Major osteoporotic fractures can be painful, disabling and are associated with an increased risk for mortality . Therefore, potent antiresorptive drugs, namely bisphosphonates and denosumab, are often used to maintain bone health and prevent fractures in aromatase inhibitor‐treated patients .…”
Section: Introductionmentioning
confidence: 99%